Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Asthma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, BDNF, CANCER, CYTOKINES, GATA3, IFN |
| Therapeutic Agents | PNS-R1 |
| KG Connections | 286 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
graph TD
Asthma["Asthma"]
Inflammation{"Inflammation"}
Asthma -->|"contributes_to"| Inflammation
Als{"Als"}
Asthma -->|"activates"| Als
Oxidative_Stress["Oxidative Stress"]
Asthma -->|"activates"| Oxidative_Stress
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"contributes_to"| Asthma
style Asthma fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | contributes_to | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 0.95 |
| Als | activates | disease | 0.95 |
| Eosinophilic Inflammation | associated_with | process | 0.90 |
| Oxidative Stress | activates | pathway | 0.80 |
| Inflammation | causes | disease | 0.75 |
| Inflammation | implicated_in | disease | 0.75 |
| Als | regulates | disease | 0.75 |
| Als | inhibits | disease | 0.75 |
| Inflammation | treats | disease | 0.75 |
| Apoptosis | activates | pathway | 0.70 |
| Immune Response | therapeutic_target | pathway | 0.70 |
| Differentiation | implicated_in | pathway | 0.70 |
| Mitophagy | activates | pathway | 0.70 |
| Mtor | regulates | pathway | 0.70 |
| Nf-Κb | regulates | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Immune Response | regulates | pathway | 0.70 |
| Ferroptosis | regulates | pathway | 0.70 |
| Pulmonary Fibrosis | contributes_to | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| ANGIOGENESIS | causes | phenotype | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Atherosclerosis | protects_against | disease | 0.65 |
| Obesity | protects_against | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Immune Response | causes | pathway | 0.60 |
| Differentiation | activates | pathway | 0.60 |
| Immune Response | protects_against | pathway | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| Er Stress | activates | pathway | 0.60 |
| Immune Response | contributes_to | pathway | 0.60 |
| Nf-Kb | activates | pathway | 0.60 |
| Pi3K/Akt | activates | pathway | 0.60 |
| Ferroptosis | inhibits | pathway | 0.60 |
| Tnf Signaling | activates | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| Dysbiosis | activates | pathway | 0.60 |
| Gut Microbiome | activates | pathway | 0.60 |
| Dysbiosis | regulates | pathway | 0.60 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.60 |
| Complement | inhibits | pathway | 0.60 |
| Oxidative Phosphorylation | treats | pathway | 0.60 |
| Glycolysis | treats | pathway | 0.60 |
| Stem Cell | implicated_in | pathway | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | inhibits | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| INFLAMMATION | contributes_to | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| protopine | treats | drug | 0.92 |
| Purinergic Receptors | targets | receptor | 0.90 |
| PNS-R1 | treats | compound | 0.90 |
| EPX | biomarker_for | biomarker | 0.88 |
| Mitochondrial Dysfunction | contributes_to | phenotype | 0.85 |
| RHOT1 | therapeutic_target | gene | 0.85 |
| OXIDATIVE STRESS | activates | gene | 0.85 |
| EPX | associated_with | biomarker | 0.85 |
| P2RY11 | therapeutic_target | receptor | 0.85 |
| Cysteinyl Leukotrienes | associated_with | compound | 0.85 |
| INFLAMMATION | causes | gene | 0.85 |
| CYTOKINES | activates | gene | 0.85 |
| MIRO1 | therapeutic_target | gene | 0.85 |
| INFLAMMATION | treats | gene | 0.85 |
| INFLAMMATION | implicated_in | gene | 0.85 |
| ALOX5 | involved_in | gene | 0.80 |
| APOPTOSIS | activates | gene | 0.75 |
| OPTN | activates | gene | 0.75 |
| Infection | associated_with | disease | 0.75 |
| FERROPTOSIS | regulates | gene | 0.75 |
| INFLAMMATION | therapeutic_target | gene | 0.75 |
| CYTOKINES | associated_with | gene | 0.75 |
| CYTOKINES | regulates | gene | 0.75 |
| MTOR | regulates | gene | 0.75 |
| TNF | activates | gene | 0.75 |
| TNF | regulates | gene | 0.75 |
| PI3K | activates | gene | 0.75 |
| NF-ΚB | regulates | gene | 0.75 |
| MITOPHAGY | activates | gene | 0.75 |
| AUTOPHAGY | regulates | gene | 0.75 |
| IFN | regulates | gene | 0.75 |
| PINK1 | activates | gene | 0.75 |
| mTOR dysregulation | causes | process | 0.70 |
| MMP9 | associated_with | protein | 0.70 |
| PTEN | activates | gene | 0.65 |
| CYTOKINES | targets | phenotype | 0.65 |
| T CELLS | causes | cell_type | 0.65 |
| P2RX7 | targets | gene | 0.65 |
| PROINFLAMMATORY CYTOKINES | contributes_to | gene | 0.65 |
| NEURON | therapeutic_target | gene | 0.65 |
| CYTOKINES | therapeutic_target | gene | 0.65 |
| CCR8 | interacts_with | gene | 0.65 |
| INFLAMMATION | interacts_with | gene | 0.65 |
| CCL2 | interacts_with | gene | 0.65 |
| CCR3 | interacts_with | gene | 0.65 |
| CCL5 | interacts_with | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Asthma in their description or question text
No additional research found