gene 1,410 words KG: EPAS1
Contents

EPAS1 Gene

🧬 Gene Info
Gene SymbolEPAS1
Full NameEndothelial PAS Domain Protein 1
AliasesHIF-2α
Chromosome2p21
Protein TypeTranscription Factor
Functionis a transcription factor that serves as the master regulator of cellular responses to hypoxia.
Amino Acids870 aa
Exons16
PathwaysApoptosis, MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway
UniProt IDQ9Y5Q3
NCBI Gene ID2034
Ensembl IDENSG00000177640
OMIM603349
GeneCardsEPAS1
Human Protein AtlasEPAS1
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
InteractionsABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
KG Connections489 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with EPAS1
OPTN interacts_with EPAS1
DNM1L interacts_with EPAS1
CANX interacts_with EPAS1
LGALS3 interacts_with EPAS1
CALCOCO2 interacts_with EPAS1
G3BP1 interacts_with EPAS1
PEX3 interacts_with EPAS1
SQSTM1 interacts_with EPAS1
BCL2 interacts_with EPAS1

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