concept

RUBCNL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBCNL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

299Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	RUBCNL
Key Genes/Proteins	ACAT1, ACETYL-COA, ACOX1, Actin, Adiponectin, ADIPOQ
Related Diseases	Als, ALS
Related Pathways	apoptosis pathway

Pathway Diagram

graph TD
    RUBCNL["RUBCNL"]
    style RUBCNL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    RUBCNL -->|"interacts"| RIPK1([RIPK1])
    RUBCNL -.->|"protects against"| Mesenchymal_Stem_Cell_Survival(Mesenchymal Stem Cell Survival)
    RUBCNL -->|"regulates"| Autophagy["Autophagy"]
    RUBCNL -.->|"inhibits"| Necroptosis["Necroptosis"]
    RUBCNL -.->|"inhibits"| Apoptosis["Apoptosis"]
    RUBCNL -.->|"inhibits"| TNF_Signaling["TNF Signaling"]
    RUBCNL -->|"interacts"| BECN1([BECN1])
    RUBCNL -->|"interacts"| Tumor["Tumor"]
    Histone_H3_Lysine_18_Lactylati["Histone H3 Lysine 18 Lactylation"] -->|"upregulates"| RUBCNL
    LYSOSOME([LYSOSOME]) -->|"regulates"| RUBCNL
    HTRA2([HTRA2]) -->|"interacts"| RUBCNL
    LC3([LC3]) -->|"interacts"| RUBCNL
    PLIN2([PLIN2]) -->|"interacts"| RUBCNL
    LAMP2([LAMP2]) -->|"interacts"| RUBCNL
    STX17([STX17]) -->|"interacts"| RUBCNL
    PPARA([PPARA]) -->|"interacts"| RUBCNL
    RAS([RAS]) -->|"interacts"| RUBCNL
    NR1H3([NR1H3]) -->|"interacts"| RUBCNL

Outgoing (139)

Target	Relation	Type	Str
RIPK1	interacts_with	protein	0.95
Mesenchymal Stem Cell Survival	protects_against	phenotype	0.91
Necroptosis	inhibits	process	0.90
Autophagy	regulates	process	0.90
Apoptosis	inhibits	process	0.90
RIPK1	inhibits	protein	0.90
autophagy pathway	participates_in	pathway	0.90
TNF Signaling	inhibits	pathway	0.88
BECN1	interacts_with	protein	0.85
Autophagy	activates	process	0.85
STX17	activates	gene	0.80
ULK1	activates	gene	0.80
SQSTM1	activates	gene	0.70
VAMP8	activates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
TFEB	activates	gene	0.70
TP53	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
SIRT1	activates	gene	0.70
SNAP29	activates	gene	0.70
ALS	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Necroptosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
Parkinson	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	activates	disease	0.65
TNFRSF1A	interacts_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	activates	gene	0.60
SIRT3	activates	gene	0.60
SREBF1	activates	gene	0.60
SREBF2	activates	gene	0.60
STING1	activates	gene	0.60
complement cascade	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
TNF	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
TNFR1	interacts_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
RAB2A	associated_with	gene	0.60

Incoming (160)

Source	Relation	Type	Str
Histone H3 Lysine 18 Lactylation	upregulates	process	0.90
rapamycin	targets	drug	0.80
ATG	activates	gene	0.80
BECN1	activates	gene	0.80
LC3	activates	gene	0.80
MTOR	activates	gene	0.80
CREB	activates	gene	0.70
MAP1LC3	activates	gene	0.70
RB1	activates	gene	0.70
RB1CC1	activates	gene	0.70
RAS	activates	gene	0.70
AMPK	activates	gene	0.70
LAMP2	activates	gene	0.70
C1Q	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
ACOX1	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
CANCER	activates	gene	0.60
ACAT1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CREBBP	activates	gene	0.60
EP300	activates	gene	0.60
FIP200	activates	gene	0.60
GAPDH	activates	gene	0.60
GSK3	activates	gene	0.60
HDAC6	activates	gene	0.60
HSPA8	activates	gene	0.60
KAT2A	activates	gene	0.60
KAT2B	activates	gene	0.60
KAT5	activates	gene	0.60
KAT8	activates	gene	0.60
LAMP2A	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PIK3C3	activates	gene	0.60
PKM2	activates	gene	0.60
RUBCN	activates	gene	0.60
DNM1L	activates	gene	0.60
GABA	activates	gene	0.60
GABARAP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RUBCNL in their description or question text

No additional research found