gene

KAT8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KAT8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

207Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

KAT8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, regulates. Associated with Neurodegeneration, Parkinson, Tumor. Connected to 106 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KAT8
Chromosome	16q24.1
Protein Type	Transferase
Function	KAT8/MOF is a highly conserved histone acetyltransferase belonging to the MYST family (MOZ, YBF2/SAS3, SAS2, TIP60).
Molecular Weight	52 kDa
Amino Acids	458 aa
Pathways	NF-κB
UniProt ID	Q9H7Z6
NCBI Gene ID	84144
Ensembl ID	ENSG00000103510
OMIM	609912
GeneCards	KAT8
Human Protein Atlas	KAT8
Primary target	H4K16ac — the hallmark modification that prevents chromatin compaction
Secondary targets	H4K5, H4K8, H2AK5, H2BK120
Associated Diseases	Neurodegeneration, Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, ATG, CALCOCO2, CBP, CREB
KG Connections	207 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KAT8 — AlphaFold Q9H7Z6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KAT8["KAT8"]
    KAT8 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    KAT8 ---|"associated"| Tumor["Tumor"]
    KAT8 ---|"associated"| Parkinson["Parkinson"]
    KAT8 ---|"associated"| RB1CC1["RB1CC1"]
    KAT8 ---|"associated"| SIRT1["SIRT1"]
    KAT8 ---|"associated"| LC3["LC3"]
    KAT8 ---|"associated"| SNAP29["SNAP29"]
    LYSOSOME["LYSOSOME"] -->|"regulates"| KAT8
    OPTN["OPTN"] ---|"associated"| KAT8
    ULK1["ULK1"] ---|"associated"| KAT8
    CALCOCO2["CALCOCO2"] ---|"associated"| KAT8
    HSPA8["HSPA8"] ---|"associated"| KAT8
    STX17["STX17"] ---|"associated"| KAT8
    SQSTM1["SQSTM1"] ---|"associated"| KAT8

Outgoing (126)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:KAT8	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
PCK2	lactylates	protein	0.94
Tumor	associated_with	disease	0.65
Heart Failure	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
OPTINEURIN	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
P62	associated_with	gene	0.60
Cell Cycle	associated_with	pathway	0.60
GENES	implicated_in	gene	0.60
Chaperone	associated_with	pathway	0.60
Mitophagy	regulates	pathway	0.60
Autophagy	associated_with	pathway	0.60
Autophagy	regulates	pathway	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
TP53	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
MAPT	implicated_in	gene	0.60
STX17	regulates	gene	0.60
KANSL1	regulates	gene	0.60
Apoptosis	associated_with	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
RUBCNL	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
Mtor	associated_with	pathway	0.60
AND	regulates	gene	0.60

Incoming (81)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:KAT8	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
LC3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
CBP	activates	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
PARKINSON'S DISEASE	implicated_in	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
GSK3	activates	gene	0.60
rapamycin	targets	drug	0.60
HSC70	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
ACETYL-COA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CREB	associated_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
P53	associated_with	gene	0.60
ACAT1	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
RB1	associated_with	gene	0.60
P62	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
HSP70	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KAT8 in their description or question text

No additional research found