concept

DMSO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DMSO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

330Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DMSO is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 122 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DMSO
Key Genes/Proteins	ABL1, ABP, ACTB, Actin, ADAM10, AIF1
Related Diseases	Aging, Als, Alzheimer, Alzheimer Disease, Alzheimer's disease
Related Pathways	Akt

Pathway Diagram

graph TD
    DMSO["DMSO"]
    DMSO -->|"causes"| CASP3["CASP3"]
    DMSO -->|"activates"| Ms["Ms"]
    DMSO -->|"expressed in"| Tumor["Tumor"]
    DMSO -->|"activates"| Leukemia["Leukemia"]
    DMSO -->|"target for"| Inflammation["Inflammation"]
    DMSO -->|"target for"| Alzheimer["Alzheimer"]
    DMSO -->|"target for"| Als["Als"]
    DMSO -->|"target for"| Neuroinflammation["Neuroinflammation"]
    DMSO -->|"activates"| Ischemia["Ischemia"]
    DMSO -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CTSD["CTSD"] -->|"activates"| DMSO
    CLN3["CLN3"] -->|"target for"| DMSO
    MTOR["MTOR"] -->|"activates"| DMSO
    P62["P62"] -->|"activates"| DMSO
    TUBULIN["TUBULIN"] -->|"activates"| DMSO
    JUN["JUN"] -->|"activates"| DMSO
    LC3["LC3"] -->|"activates"| DMSO
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| DMSO
    SQSTM1["SQSTM1"] -->|"activates"| DMSO
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"activates"| DMSO

Outgoing (217)

Target	Relation	Type	Str
Autophagy	associated_with	pathway	0.70
CASP3	causes	gene	0.70
MAP1LC3	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
LC3	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
Ms	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	activates	disease	0.65
Leukemia	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	associated_with	disease	0.65
BCL2	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
AKT	associated_with	gene	0.60
Lysosomal Degradation	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Actin	associated_with	protein	0.60
Cathepsin	associated_with	protein	0.60
Tubulin	activates	protein	0.60
Alzheimer's disease	activates	disease	0.60
neurons	expressed_in	cell_type	0.60
IBA1	regulates	gene	0.60
PPARA	regulates	gene	0.60
Alzheimer's disease	regulates	disease	0.60
PI3K	inhibits	gene	0.60
Wnt signaling	participates_in	pathway	0.60
ROCK	inhibits	gene	0.60
GFP	regulates	gene	0.60
LAMP2	regulates	gene	0.60
LC3	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
MTORC1	regulates	gene	0.60
PI3K	associated_with	gene	0.60

Incoming (113)

Source	Relation	Type	Str
rapamycin	targets	drug	0.70
GFP	associated_with	gene	0.70
MAP1LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CTSD	regulates	gene	0.60
CREB1	regulates	gene	0.60
DLG4	regulates	gene	0.60
ABL1	regulates	gene	0.60
ACTB	regulates	gene	0.60
ADAM10	regulates	gene	0.60
AIF1	regulates	gene	0.60
APOE	regulates	gene	0.60
APP	regulates	gene	0.60
BDNF	regulates	gene	0.60
BECN1	regulates	gene	0.60
CD68	regulates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
NLRP3	therapeutic_target	gene	0.60
CXCL10	therapeutic_target	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	therapeutic_target	gene	0.60
RAS	therapeutic_target	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
GPNMB	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
P2RY12	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
C1QA	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
GENES	activates	gene	0.60
ENDOSOMES	activates	gene	0.60
MTORC1	activates	gene	0.60
LC3	associated_with	gene	0.60
EGFR	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
DRD1	therapeutic_target	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
STAT3	activates	gene	0.60
EGF	associated_with	gene	0.60
EEA1	associated_with	gene	0.60
RNA	activates	gene	0.60
ATG7	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DMSO in their description or question text

No additional research found