gene

MAP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

388Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAP2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with AD, ALI, ALS. Connected to 129 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP2
Full Name	MAP2 — Microtubule-Associated 2
Aliases	Microtubule-Associated Protein 2
Protein Type	Protein
Function	is a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expression	neuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Molecular Weight	280 kDa
Pathways	Apoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt ID	Search UniProt
GeneCards	MAP2
Human Protein Atlas	MAP2
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ACTB, Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	388 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAP2 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP2["MAP2"] -->|"interacts"| Als["Als"]
    MAP2["MAP2"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    MAP2["MAP2"] -->|"activates"| Alzheimer["Alzheimer"]
    MAP2["MAP2"] -->|"activates"| Ms["Ms"]
    MAP2["MAP2"] -->|"activates"| Ischemia["Ischemia"]
    MAP2["MAP2"] -->|"activates"| Als_1["Als"]
    ACTB["ACTB"] -->|"activates"| MAP2["MAP2"]
    LAMP1["LAMP1"] -->|"associated"| MAP2["MAP2"]
    MTOR["MTOR"] -->|"associated"| MAP2["MAP2"]
    LC3["LC3"] -->|"associated"| MAP2["MAP2"]
    style MAP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (238)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Microtubule	associated_with	process	0.90
neurons	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	associated_with	disease	0.65
Neuroblastoma	biomarker_for	disease	0.65
Neuropathy	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Type 2 Diabetes	protects_against	disease	0.65
Insulin Resistance	biomarker_for	disease	0.65
Dementia	protects_against	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Ischemia	causes	disease	0.65
Stroke	causes	disease	0.65
Ischemia	activates	disease	0.65
Als	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
SYT1	associated_with	gene	0.60
TAU	interacts_with	gene	0.60
MTOR	activates	entity	0.60
P62	activates	entity	0.60
SNAP25	activates	entity	0.60
SQSTM1	activates	entity	0.60
SYN1	activates	entity	0.60
SYT1	activates	entity	0.60
TFEB	activates	entity	0.60
TUBB3	activates	entity	0.60
TUBULIN	activates	entity	0.60
P62	associated_with	gene	0.60
AKT	activates	gene	0.60
BDNF	activates	gene	0.60
BDNF	biomarker_for	gene	0.60
GAP43	biomarker_for	gene	0.60
CD44	activates	gene	0.60

Incoming (150)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
APP	interacts_with	gene	0.60
ACTB	activates	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ATG7	activates	gene	0.60
JUN	activates	gene	0.60
SQSTM1	associated_with	gene	0.60
MAP1B	interacts_with	gene	0.60
CXCR3	therapeutic_target	gene	0.60
IBA1	activates	gene	0.60
CTSD	activates	gene	0.60
TFR1	regulates	gene	0.60
GPX4	regulates	gene	0.60
APOE	regulates	gene	0.60
FERROPORTIN	regulates	gene	0.60
HDAC2	activates	gene	0.60
BDNF	activates	gene	0.60
AKT	activates	gene	0.60
CASPASE1	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MIRNAS	biomarker_for	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
JAK	therapeutic_target	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PRKAA	associated_with	gene	0.60
CREB	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
INSULIN RESISTANCE	biomarker_for	gene	0.60
GLUT4	biomarker_for	gene	0.60
RAS	protects_against	gene	0.60
GENES	protects_against	gene	0.60
BAX/BCL2	biomarker_for	gene	0.60
DNA	protects_against	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
STROKE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP2 in their description or question text

No additional research found

MAP2

Understanding Entity Pages

Summary

Wiki Pages (13)

MAP2 Protein — Microtubule-Associated Protein 2

MAP2K5

MAP2K2 Gene

MAP2K3 Protein (MEK3)

MAP2K7

MAP2K1 Gene

MAP2 Protein

MAP2K4 — Mitogen-Activated Protein Kinase Kinase 4

MAP2K6

MAP2 Gene

MAP2K3 - Mitogen-Activated Protein Kinase Kinase 3

MAP2K1/MEK1 Protein

MAP2K2/MEK2 Protein