protein

TUBULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

550Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TUBULIN is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Alzheimer, Inflammation. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TUBULIN
Protein Family	Tubulin family
Function	is a protein encoded by the TUBB gene.
Subcellular Localization	Microtubules, cytoplasm
Molecular Weight	55 kDa
Amino Acids	4477 aa
Pathways	Autophagy, Phagocytosis, Proteasome, Ubiquitin-Proteasome
UniProt ID	P07437
GeneCards	TUBULIN
Human Protein Atlas	TUBULIN
GTP-binding domain	α-Tubulin binds GTP at its N-terminal domain (though the GTP is not hydrolyzed)
Heterodimer formation	α-Tubulin binds β-Tubulin to form α/β heterodimers, the basic subunit of microtubules
C-terminal tail	The acidic C-terminal tail interacts with microtubule-associated proteins (MAPs)
Anterograde transport	Kinesin motors carry vesicles, proteins, organelles toward synaptic terminals
Retrograde transport	Dynein motors return materials to the cell body
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ms, Pyroptosis
Interactions	ACHE, ACTB, Actin, AGING, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	426 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TUBULIN — AlphaFold P07437 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

α-Tubulin (Alpha-Tubulin)

entity · 1110 words

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Pathway Diagram

graph TD
    TUBULIN["TUBULIN"]
    TUBULIN -->|"activates"| Ischemia["Ischemia"]
    TUBULIN -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TUBULIN -->|"activates"| Alzheimer["Alzheimer"]
    TUBULIN -.biomarker for.-> Neuroinflammation["Neuroinflammation"]
    TUBULIN -.biomarker for.-> Inflammation["Inflammation"]
    TUBULIN -->|"activates"| ALS["ALS"]
    TUBULIN -->|"regulates"| LYSOSOME["LYSOSOME"]
    TUBULIN -->|"regulates"| GJA1["GJA1"]
    TAU["TAU"] -->|"interacts"| TUBULIN
    ROS["ROS"] -->|"activates"| TUBULIN
    AXON["AXON"] -->|"activates"| TUBULIN
    APOPTOSIS["APOPTOSIS"] -->|"activates"| TUBULIN
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| TUBULIN

Outgoing (299)

Target	Relation	Type	Str
cytoskeletal integrity	involved_in	process	0.95
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Parkinson	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	enhances	disease	0.65
Aging	activates	disease	0.65
Cancer	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	protects_against	disease	0.65
Parkinson	regulates	disease	0.65
Als	enhances	disease	0.65
Pyroptosis	causes	disease	0.65
Inflammation	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuropathy	inhibits	disease	0.65
Als	causes	disease	0.65
ALS	regulates	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
SYN1	associated_with	gene	0.60
MAP2	associated_with	gene	0.60
CDC42	regulates	gene	0.60
SNAP25	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
VIM	associated_with	gene	0.60
CASP3	regulates	gene	0.60
ACTB	activates	gene	0.60
CTSD	associated_with	gene	0.60
STK11	associated_with	gene	0.60
PRKAA1	inhibits	gene	0.60
LC3	associated_with	gene	0.60
STK11	inhibits	gene	0.60
MTOR	associated_with	gene	0.60

Incoming (251)

Source	Relation	Type	Str
MAPT	interacts_with	protein	0.90
TAU	interacts_with	protein	0.72
PYROPTOSIS	causes	gene	0.60
ATP	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GASDERMIN	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TJP1	associated_with	gene	0.60
ALS	causes	gene	0.60
GASDERMIN	activates	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
BPMC	inhibits	gene	0.60
MAO	biomarker_for	gene	0.60
NEUROTOXICITY	inhibits	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PARKINSON	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
DMSO	activates	gene	0.60
EXOSOMES	regulates	gene	0.60
LYSOSOME	activates	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
PYROPTOSIS	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
GENES	associated_with	gene	0.60
SYN2A	inhibits	gene	0.60
MYELIN	activates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
RNA	activates	gene	0.60
CREB	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	protects_against	gene	0.60
LKB1	inhibits	gene	0.60
AXON	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
LKB1	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
AXON	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
PHAGOCYTOSIS	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
TAU	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUBULIN in their description or question text

No additional research found