gene

DRD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

301Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DRD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 103 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DRD1
Full Name	Dopamine Receptor D1
Chromosome	5q35.2
Protein Type	Receptor
Function	The D1 receptor is a postsynaptic dopamine receptor that:
Primary Expression	Striatum, Cortex, Nucleus accumbens, Olfactory bulb
Pathways	MAPK
UniProt ID	P21709
NCBI Gene ID	1817
Ensembl ID	ENSG00000184845
GeneCards	DRD1
Human Protein Atlas	DRD1
Associated Diseases	Als, Alzheimer, Autism, Bipolar, Cancer
Interactions	ADRA1A, ADRA1B, AND, BDNF, CACNA1B, CACNA1H
KG Connections	301 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DRD1 — AlphaFold P21709 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DRD1 Gene

gene · 1227 words

→

Dopamine Receptor D1 (DRD1)

protein · 557 words

→

Pathway Diagram

graph TD
    DRD1["DRD1"]
    DRD1 -->|"activates"| Ms["Ms"]
    DRD1 -->|"activates"| Als["Als"]
    DRD1 -->|"regulates"| Inflammation["Inflammation"]
    DRD1 -->|"target for"| Alzheimer["Alzheimer"]
    DRD1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    DRD1 -->|"activates"| GRIA1["GRIA1"]
    DRD1 -->|"activates"| ADRA1A["ADRA1A"]
    DRD1 -->|"activates"| HRH1["HRH1"]
    DRD2["DRD2"] -->|"activates"| DRD1
    HRH3["HRH3"] -->|"activates"| DRD1
    HCRTR2["HCRTR2"] -->|"activates"| DRD1
    ADRA1B["ADRA1B"] -->|"activates"| DRD1
    CLN3["CLN3"] -->|"target for"| DRD1
    DMSO["DMSO"] -->|"target for"| DRD1
    ERK["ERK"] -->|"activates"| DRD1
    MICROGLIA["MICROGLIA"] -->|"regulates"| DRD1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| DRD1
    ASTROCYTES["ASTROCYTES"] -->|"regulates"| DRD1

Outgoing (192)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
NEURONS	expresses	cell_type	0.70
DRD2	activates	gene	0.70
NLRP3	expresses	gene	0.70
NOTCH	transports	gene	0.70
NEURONS	activates	cell_type	0.70
DRD2	expresses	gene	0.70
PDGF	expresses	gene	0.70
Huntington	encodes	disease	0.65
DRD2	associated_with	gene	0.65
NEURON	contributes_to	cell_type	0.65
Parkinson	associated_with	disease	0.65
Huntington	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Huntington	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Synucleinopathy	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Bipolar	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
INFLAMMATION	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
Ras	associated_with	protein	0.60
GABA	causes	gene	0.60
NR3C2	causes	gene	0.60
GABA	expressed_in	gene	0.60
NEURON	expresses	cell_type	0.60
MARCH7	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
neurodegeneration	associated_with	disease	0.60
Circadian Rhythm	associated_with	pathway	0.60
PDLIM5	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60

Incoming (109)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DRD1	data_in	dataset_row	0.00
genes-drd1	documents	wiki_page	1.00
ds-83b31ef18d49	data_in	dataset	1.00
genes-drd1	describes	wiki_page	1.00
BDNF	expressed_in	gene	0.70
DBH	transports	gene	0.70
NEUROINFLAMMATION	treats	phenotype	0.70
HUNTINGTON	expressed_in	gene	0.60
LYSOSOME	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
SYNUCLEINOPATHY	associated_with	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
HUNTINGTON'S DISEASE	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
HUNTINGTON	encodes	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
G72	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
AD	regulates	gene	0.60
ASTROCYTE	regulates	cell_type	0.60
AΒ	regulates	gene	0.60
NLRP3	activates	gene	0.60
ESRRG	inhibits	gene	0.60
GABRB2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
COMT	associated_with	gene	0.60
DDC	associated_with	gene	0.60
HTTLPR	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
CNR1	causes	gene	0.60
MTDNA	associated_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1H	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CACNA1B	interacts_with	gene	0.60
BDNF	activates	gene	0.60
CNR1	activates	gene	0.60
BDNF	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DRD1 in their description or question text

No additional research found