gene

HTT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

807Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

HTT is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, inhibits. Associated with AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA, Aging. Connected to 118 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HTT
Full Name	Huntingtin
Chromosome	4p16.3.
Function	is a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Subcellular Localization	and protein interactions
Molecular Weight	350 kDa
Amino Acids	144 aa
Exons	67
Pathways	Autophagy, Dna Repair
UniProt ID	P42857
NCBI Gene ID	3064
Ensembl ID	ENSG00000197393
OMIM	143100
GeneCards	HTT
Human Protein Atlas	HTT
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	dimethyl fumarate, rapamycin, RAPAMYCIN
Interactions	ABP, ACHE, Actin, AD, AKT, ALS
KG Connections	806 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — HTT Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6EZ8 — X-ray / Cryo-EM

🔮 AI Predicted Structure

P42858 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HTT["HTT"] -->|"causes"| Dementia["Dementia"]
    HTT["HTT"] -->|"implicated in"| Huntington["Huntington"]
    HTT["HTT"] -->|"interacts"| Huntington_1["Huntington"]
    HTT["HTT"] -.->|"inhibits"| Huntington_2["Huntington"]
    HTT["HTT"] -->|"encodes"| huntingtin["huntingtin"]
    HTT["HTT"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Huntington_3["Huntington"] -->|"interacts"| HTT["HTT"]
    ACTB["ACTB"] -->|"associated"| HTT["HTT"]
    GABARAP["GABARAP"] -->|"associated"| HTT["HTT"]
    ULK1["ULK1"] -->|"associated"| HTT["HTT"]
    style HTT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (512)

Target	Relation	Type	Str
Huntington's Disease	causes	disease	0.95
amyloid-like fibrils	forms	phenotype	0.94
Huntington's disease	causes	disease	0.90
protein aggregation	promotes	process	0.90
Dementia	causes	disease	0.90
Calcium Homeostasis	regulates	process	0.85
ASK1	activates	protein	0.85
neurons	expressed_in	cell_type	0.80
neurodegeneration	causes	disease	0.80
Huntington's disease	treats	disease	0.80
Huntington's disease	associated_with	disease	0.80
nuclear localization	promotes	process	0.80
SOD1	activates	gene	0.70
SNCA	activates	gene	0.70
STING	regulates	gene	0.70
PARP1	interacts_with	gene	0.70
NRF2	interacts_with	gene	0.70
TAU	activates	gene	0.70
MAPT	activates	gene	0.70
MOTOR NEURON	activates	cell_type	0.70
NEURONS	interacts_with	cell_type	0.70
TAU	interacts_with	gene	0.70
LAMP1	interacts_with	gene	0.70
SOD1	interacts_with	gene	0.70
SYT1	activates	gene	0.70
Huntington	inhibits	entity	0.70
Huntington	interacts_with	entity	0.70
MAPT	interacts_with	protein	0.70
striatum	expressed_in	brain_region	0.70
huntingtin	encodes	protein	0.70
astrocytes	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
Huntington's disease	targets	disease	0.70
Huntington	associated_with	entity	0.70
Frontotemporal Dementia	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Ftd	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
STRIATUM	regulates	brain_region	0.65
ALS	associated_with	disease	0.65
RAPAMYCIN	inhibits	drug	0.65
RAPAMYCIN	interacts_with	drug	0.65
Neurodegeneration	associated_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Huntington	transports	disease	0.65
Neurodegeneration	transports	disease	0.65

Incoming (295)

Source	Relation	Type	Str
entities-hsp90-protein	associated_with	wiki	0.00
HUNTINGTON	associated_with	disease	0.90
h-10b5bf6f	targets	hypothesis	0.90
h-3a4f2027	targets_gene	hypothesis	0.90
cell-types-striatal-medium-spiny-neurons-huntingtons	describes	wiki	0.90
SDA-2026-04-02-gap-crispr-neurodegeneration-20260402	targets	analysis	0.90
AMYOTROPHIC LATERAL SCLEROSIS	regulates	disease	0.70
ATG5	regulates	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
BMP	interacts_with	gene	0.70
FUS	interacts_with	gene	0.70
ATG5	interacts_with	gene	0.70
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.70
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.70
FTD	interacts_with	disease	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
BECN1	transports	gene	0.70
FRONTOTEMPORAL DEMENTIA	activates	disease	0.70
GLUTAMATERGIC	transports	cell_type	0.70
ACHE	expresses	gene	0.70
AMPK	activates	gene	0.70
rapamycin	targets	drug	0.70
DNA	regulates	gene	0.70
Huntington	interacts_with	entity	0.70
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.65
BDNF	phosphorylates	gene	0.65
DEPRESSION	causes	disease	0.65
FAN1	activates	gene	0.60
APP	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
HD	protects_against	gene	0.60
CAG REPEATS	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
BDNF	expressed_in	gene	0.60
CHCHD2	associated_with	gene	0.60
AKT	regulates	gene	0.60
GABARAP	regulates	gene	0.60
MTORC1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MECP2	activates	gene	0.60
CYP46A1	inhibits	gene	0.60
DNA METHYLATION	interacts_with	biological_process	0.60
ALS	co_discussed	gene	0.60
AD	interacts_with	gene	0.60
ASTROCYTES	associated_with	cell_type	0.60
AKT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.90 · 2026-04-02

Related Research

Hypotheses and analyses mentioning HTT in their description or question text

No additional research found

HTT

Understanding Entity Pages

Summary

Wiki Pages (11)

HTT (Huntingtin)

Huntingtin Protein (HTT)

Huntingtin (HTT)

HTT Gene-Mechanism-Therapy Causal Chain — Huntington's Disease

mHTT Clearance Mechanisms in Huntington's Disease

mHTT Clearance Mechanisms in Huntington's Disease

Mutant Huntingtin Protein (mHTT) - Biomarker

HTT — Huntingtin Gene Entity Page

Huntingtin (HTT) Protein

Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Validation

HTT Transcriptional Dysregulation Pathway

Pathway Diagram

Outgoing (512)

Incoming (295)

Targeting Hypotheses (0)

Mentioning Analyses (2)

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Experiments (0)

Related Papers (0)

Debates (2)

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

Related Research