TUBB3

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

TUBB3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Als, Alzheimer. Connected to 179 entities in the SciDEX knowledge graph.

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flowchart TD
    TUBB3["TUBB3
Neuronal Tubulin
Beta-3"]
    
    %% Microtubule and Cytoskeleton
    Microtubules["Microtubule
Assembly"]
    Cytoskeleton["Neuronal
Cytoskeleton"]
    
    %% Associated Proteins
    HDAC6["HDAC6
Tubulin Deacetylase"]
    VIM["VIM
Vimentin"]
    SRC["SRC
Kinase"]
    
    %% Autophagy Pathway
    BECN1["BECN1
Beclin-1"]
    MAP1LC3B["MAP1LC3B
LC3B"]
    Autophagy["Autophagy
Process"]
    
    %% Neurodegenerative Diseases
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["ALS
Motor Neuron Disease"]
    Huntington["Huntington's
Disease"]
    MS["Multiple
Sclerosis"]
    
    %% Cellular Processes
    Apoptosis["Neuronal
Apoptosis"]
    Neurodegeneration["Neurodegeneration
Process"]
    
    %% Connections
    TUBB3 -->|"forms"| Microtubules
    Microtubules -->|"maintains"| Cytoskeleton
    
    HDAC6 -->|"deacetylates"| TUBB3
    TUBB3 -->|"associates_with"| VIM
    TUBB3 -->|"inhibits"| SRC
    
    TUBB3 -->|"regulates"| BECN1
    TUBB3 -->|"associates_with"| MAP1LC3B
    BECN1 -->|"initiates"| Autophagy
    MAP1LC3B -->|"mediates"| Autophagy
    
    TUBB3 -->|"activates"| Alzheimer
    TUBB3 -->|"regulates"| Parkinson
    TUBB3 -->|"therapeutic_target"| ALS
    TUBB3 -->|"associated_with"| Huntington
    TUBB3 -->|"activates"| MS
    
    TUBB3 -->|"therapeutic_target"| Apoptosis
    TUBB3 -->|"activates"| Neurodegeneration
    
    Cytoskeleton -->|"dysfunction_leads_to"| Neurodegeneration
    Autophagy -->|"impairment_causes"| Neurodegeneration
    
    %% Styling
    style TUBB3 fill:#006494
    style Autophagy fill:#1b5e20
    style BECN1 fill:#1b5e20
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style Huntington fill:#ef5350
    style MS fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Apoptosis fill:#ef5350
    style HDAC6 fill:#4a1a6b
    style SRC fill:#4a1a6b
    style Microtubules fill:#5d4400
    style Cytoskeleton fill:#5d4400

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