gene

SNAP25

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNAP25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

659Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

10Experiments

3Debates

Summary

SNAP25 gene page - synaptic vesicle protein, AD/PD/ALS

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🧬 Gene Info

Gene Symbol	SNAP
Aliases	SNAP25
Chromosome	20p12
Target Class	Structural Protein
Function	Snap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Mechanism of Action	Protein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation
Druggability	Low (0.33)
Clinical Stage	Approved
GeneCards	SNAP
Human Protein Atlas	SNAP
N-terminal region	Contains palmitoylation sites for membrane attachment
SNARE motif (Habc domain)	Forms coiled-coil structure with syntaxin-1 and VAMP2
C-terminal region	Two SNARE motifs (SN1 and SN2) separated by a 9-residue linker
SNAP-25	Provides two alpha-helical SNARE motifs
Syntaxin-1	Membrane-bound Q-SNARE on presynaptic plasma membrane
Associated Diseases	Als, Alzheimer, Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	ACTB, ACTG1, Actin, AD, AKT, ALZHEIMER
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Targeting Synaptic Vesicle Release Machinery to Bl Synaptic Vesicle Tau Capture Inhibition Synaptic Vesicle Tau Capture Inhibition
KG Connections	659 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure Comparison — SNAP25 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1KIL — X-ray / Cryo-EM

🔮 AI Predicted Structure

P60880 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SNAP25["SNAP25"] -->|"regulates"| Synaptic_Vesicle_Tau_Capture_I["Synaptic Vesicle Tau Capture Inhibition"]
    SNAP25["SNAP25"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SNAP25["SNAP25"] -->|"activates"| Alzheimer["Alzheimer"]
    SNAP25["SNAP25"] -->|"activates"| Ms["Ms"]
    SNAP25["SNAP25"] -->|"activates"| Ischemia["Ischemia"]
    SNAP25["SNAP25"] -->|"activates"| Inflammation["Inflammation"]
    h_73e29e3a["h-73e29e3a"] -->|"therapeutic target"| SNAP25["SNAP25"]
    STX11["STX11"] -->|"interacts"| SNAP25["SNAP25"]
    ACTB["ACTB"] -->|"activates"| SNAP25["SNAP25"]
    LAMP1["LAMP1"] -->|"associated"| SNAP25["SNAP25"]
    style SNAP25 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (352)

Target	Relation	Type	Str
Fibroblast Activation	inhibits	process	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Schizophrenia	biomarker_for	disease	0.85
Synaptic Dysfunction	biomarker_for	mechanism	0.85
autophagy pathway	participates_in	pathway	0.80
Synaptic function	involved_in	process	0.80
VAMP2	associated_with	gene	0.70
SOD1	associated_with	gene	0.70
TAU	causes	protein	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	stabilizes	disease	0.70
ALS	treats	disease	0.70
Synaptic Vesicle Tau Capture Inhibition	regulates	mechanism	0.70
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Prion	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Epilepsy	activates	disease	0.65
TAU	associated_with	gene	0.65
Depression	interacts_with	disease	0.65
Schizophrenia	interacts_with	disease	0.65
synaptic plasticity	participates_in	pathway	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
FIBROSIS	inhibits	disease	0.65
FIBROSIS	regulates	disease	0.65
FIBROBLASTS	inhibits	cell_type	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	associated_with	disease	0.65
Depression	regulates	disease	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Ischemia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Als	biomarker_for	disease	0.65
Dementia	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	activates	disease	0.65

Incoming (307)

Source	Relation	Type	Str
SDA-2026-04-02-gap-tau-prop-20260402003221-H006	targets	hypothesis	0.90
STX11	interacts_with	gene	0.90
SV2A	interacts_with	protein	0.85
h-73e29e3a	targets	hypothesis	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.74
GRIN2A	biomarker_for	gene	0.70
GRIN2B	associated_with	gene	0.70
IBA1	regulates	gene	0.70
PSEN1	associated_with	gene	0.70
APOE	associated_with	gene	0.70
ATG7	regulates	gene	0.70
GFAP	regulates	gene	0.70
PSD95	biomarker_for	gene	0.70
PI3K/AKT/MTOR	activates	pathway	0.70
AIF1	regulates	gene	0.70
APP	regulates	gene	0.70
GRIA1	activates	gene	0.70
GRIN2A	activates	gene	0.70
NEURONS	expresses	cell_type	0.70
GABRA1	activates	gene	0.70
GABRG2	activates	gene	0.70
TAU PHOSPHORYLATION	activates	phenotype	0.70
TAU	associated_with	protein	0.70
TAU	interacts_with	protein	0.70
TAU	inhibits	protein	0.70
TAU	treats	protein	0.70
TAU	phosphorylates	protein	0.70
TAU	activates	protein	0.70
AMPK	activates	gene	0.70
ALZHEIMER	associated_with	gene	0.65
AMYLOID	associated_with	gene	0.65
RAPAMYCIN	activates	drug	0.65
TAU	regulates	protein	0.65
PI3K	activates	gene	0.65
PVALB	associated_with	gene	0.60
AND	associated_with	gene	0.60
GSDME	activates	gene	0.60
PSMD14	interacts_with	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
PINK1	activates	gene	0.60
NLRP3	activates	gene	0.60
GFAP	activates	gene	0.60
BDNF	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Targeting Synaptic Vesicle Release Machinery to Block Tau Ex	0.630	neuroscience	Trans-synaptic tau spreading and propaga
Synaptic Vesicle Tau Capture Inhibition	0.554	Alzheimer's Disease	Tau propagation mechanisms and therapeut
Synaptic Vesicle Tau Capture Inhibition	0.547	neurodegeneration	Tau propagation mechanisms and therapeut

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.740

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
s:** - Compare tau strain spreading in EXT1/EXT2 conditional knockout	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$260,000
4R-Tau Targeting Therapies for PSP and CBS	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
Anti-Tau Immunotherapy Dosing Optimization	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tau	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$170,000
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have N	clinical	ALS	0.400	0.50	human	proposed	$7,500,000
CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$160,000
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Prion Strain Diversity and Selective Vulnerability	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$400,000
Synaptic Vesicle Trafficking Dysfunction Validation in Parkinson's Dis	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217]	Chang CH, Lin CH, Lane HY	Int J Mol Sci	2021	1
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641]	Zhang X, Wei M, Fan J, Yan W, Zha X, Son	Autophagy	2021	1
Biomarkers of synaptic degeneration in Alzheimer's disease. [PMID:39701184]	Cheng Q, Fan Y, Zhang P, Liu H, Han J, Y	Ageing research reviews	2025	0
Common Mechanism Underlying Synaptic Dysfunction Caused by Preformed Fibril-Indu [PMID:41027737]	["Dimitrov D", "Raja S", "Noor H", "Taka	The Journal of neuroscience :	2025	0
Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzh [PMID:40993829]	Nussbaumer J, Barve A, Zufferey V, Espou	Translational neurodegeneratio	2025	0
SNAP25 variant I67N: synaptic phenotypes, drug response and proteome changes in [PMID:40181518]	Østergaard M, Barbagallo P, Frederiksen	Brain : a journal of neurology	2025	0
Microglia mediate memory dysfunction via excitatory synaptic elimination in a fr [PMID:39285282]	["Li S", "Liu H", "Lv P", "Yao Y", "Peng	Journal of neuroinflammation	2024	0
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolati [PMID:37992714]	["Guo B", "Xi K", "Mao H", "Ren K", "Xia	Neuron	2024	0
Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567]	["Porzuczek J"]	Sensors (Basel, Switzerland)	2024	0
Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum [PMID:38325331]	Nilsson J, Pichet Binette A, Palmqvist S	Brain	2024	0
The Relationship between SNAP25 and Some Common Human Neurological Syndromes. [PMID:38963116]	Shu J, Peng F, Li J, Liu Y, Li X et al.	Curr Pharm Des	2024	0
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J et a	Front Immunol	2024	0
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656]	Wang W, Lu J, Pan N, Zhang H, Dai J, Li	Frontiers in immunology	2024	0
A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012]	["Azimjonov J", "\u00d6zmen A", "Varan M	Multimedia tools and applicati	2023	0
Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesic [PMID:37343100]	Papantoniou C, Laugks U, Betzin J, Capit	Science advances	2023	0
Copper Induces Cognitive Impairment in Mice via Modulation of Cuproptosis and CR [PMID:36839332]	Zhang Y, Zhou Q, Lu L, Su Y, Shi W, Zhan	Nutrients	2023	0
Concerns about the reliability of a trial of oral progesterone for preterm birth [PMID:35654321]	Gravesteijn Benjamin Y; Thornton Jim G;	American Journal of Obstetrics	2022	0
Disorders of synaptic vesicle fusion machinery. [PMID:32916768]	Melland H, Arvell EH, Gordon SL	J Neurochem	2021	0
Cysteine string proteins. [PMID:32044380]	Gundersen CB	Prog Neurobiol	2020	0
Sex Differences in Frail Older Adults with Foot Pain in a Spanish Population: An [PMID:32847063]	["Navarro-Flores E", "Romero-Morales C",	International journal of envir	2020	0

Debates (3)

Multi-agent debates referencing this entity

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Related Research

Hypotheses and analyses mentioning SNAP25 in their description or question text

No additional research found

SNAP25

Understanding Entity Pages

Summary

Wiki Pages (3)

SNAP-25

SNAP25 (Synaptosomal-Associated Protein 25)

SNAP25 Gene - Synaptosomal-Associated Protein 25

Pathway Diagram

Outgoing (352)

Incoming (307)

Targeting Hypotheses (3)

Mentioning Analyses (2)

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Tau propagation mechanisms and therapeutic interception points

Experiments (10)

Related Papers (20)

Debates (3)

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research