gene

CLN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

48Outgoing

21Incoming

0Experiments

0Debates

Summary

CLN3 gene encoding a lysosomal transmembrane protein defective in juvenile neuronal ceroid lipofuscinosis (Batten disease)

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🧬 Gene Info

Gene Symbol	CLN3
Aliases	Batten disease, Battenin
Function	encodes a lysosomal/endosomal transmembrane protein that is critical for neuronal function and survival.
Molecular Weight	48 kDa
Amino Acids	438 aa
Ensembl ID	ENSG00000158966
GeneCards	CLN3
Human Protein Atlas	CLN3
Associated Diseases	Cancer, Cln3 Disease, Ms, neurodegeneration
KG Connections	69 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CLN3 Gene - Ceroid Lipofuscinosis, Neuronal 3

gene · 1858 words

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CLN3 Protein (Battenin)

protein · 672 words

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Pathway Diagram

graph TD
    CLN3["CLN3"]
    Als{"Als"}
    CLN3 -->|"expressed in"| Als
    Cancer{"Cancer"}
    CLN3 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    CLN3 -->|"expressed in"| Tumor
    Inflammation{"Inflammation"}
    CLN3 -->|"therapeutic target"| Inflammation
    Alzheimer{"Alzheimer"}
    CLN3 -->|"therapeutic target"| Alzheimer
    CLN3 -->|"therapeutic target"| Als
    Neuroinflammation{"Neuroinflammation"}
    CLN3 -->|"therapeutic target"| Neuroinflammation
    Ms{"Ms"}
    CLN3 -->|"therapeutic target"| Ms
    Aging{"Aging"}
    CLN3 -->|"biomarker for"| Aging
    CLN3 -->|"interacts with"| Ms
    GABARAPL2["GABARAPL2"]
    CLN3 -->|"expressed in"| GABARAPL2
    SNX2["SNX2"]
    CLN3 -->|"expressed in"| SNX2
    style CLN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
Cln3 Disease	causes	disease	0.95
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Inflammation	therapeutic_target	disease	0.65
GABARAPL2	expressed_in	gene	0.60
SNX2	expressed_in	gene	0.60
ATG10	expressed_in	gene	0.60
WIPI2	expressed_in	gene	0.60
CXCL10	therapeutic_target	gene	0.60
C1QA	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
DRD1	therapeutic_target	gene	0.60
GPNMB	biomarker_for	gene	0.60
NLRP3	therapeutic_target	gene	0.60
CX3CR1	biomarker_for	gene	0.60
P2RY12	biomarker_for	gene	0.60
CANCER	expressed_in	gene	0.60
neurodegeneration	associated_with	disease	0.60
DMSO	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
TAU PATHOLOGY	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	therapeutic_target	gene	0.60
App	associated_with	protein	0.60
CANCER	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	biomarker_for	gene	0.60
Stem Cell	associated_with	cell_type	0.60
Neuron	associated_with	cell_type	0.60
neurodegeneration	causes	disease	0.60
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
disease	expressed_in	disease	0.50

Incoming (21)

Source	Relation	Type	Str
NEUROINFLAMMATION	therapeutic_target	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	biomarker_for	gene	0.60
DMSO	therapeutic_target	gene	0.60
TAU PATHOLOGY	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
NLRP3	therapeutic_target	gene	0.60
CXCL10	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	therapeutic_target	gene	0.60
RAS	therapeutic_target	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
DRD1	therapeutic_target	gene	0.60
CX3CR1	biomarker_for	gene	0.60
TAU	therapeutic_target	gene	0.60
C1QA	therapeutic_target	gene	0.60
P2RY12	biomarker_for	gene	0.60
GPNMB	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLN3 in their description or question text

No additional research found