gene

SYT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

229Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

SYT1 encodes synaptotagmin-1, the primary calcium sensor for fast synaptic vesicle exocytosis. Dysfunction contributes to synaptic failure in Alzheimer's disease, Parkinson's disease, and ALS.

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🧬 Gene Info

Gene Symbol	SYT1
Full Name	Synaptotagmin 1
Chromosome	12q21.2
Function	Synaptotagmin 1 is a presynaptic vesicular protein that functions as the calcium sensor for fast neurotransmitter release
Amino Acids	421 aa
Pathways	Apoptosis, Autophagy, autophagy pathway, oxidative stress response
UniProt ID	P21579
NCBI Gene ID	6856
Ensembl ID	ENSG00000130147
OMIM	185580
GeneCards	SYT1
Human Protein Atlas	SYT1
Associated Diseases	Alzheimer, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, Actin, AD, ALZHEIMER, ALZHEIMER DISEASE, AMPK
KG Connections	228 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SYT1 — AlphaFold P21579 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYT1["SYT1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYT1["SYT1"] -->|"activates"| Alzheimer["Alzheimer"]
    SYT1["SYT1"] -->|"activates"| Ms["Ms"]
    SYT1["SYT1"] -->|"activates"| Ischemia["Ischemia"]
    SYT1["SYT1"] -->|"activates"| Inflammation["Inflammation"]
    SYT1["SYT1"] -->|"activates"| Aging["Aging"]
    ACTB["ACTB"] -->|"activates"| SYT1["SYT1"]
    LAMP1["LAMP1"] -->|"associated"| SYT1["SYT1"]
    MTOR["MTOR"] -->|"associated"| SYT1["SYT1"]
    LC3["LC3"] -->|"associated"| SYT1["SYT1"]
    style SYT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
Synaptic Dysfunction	biomarker_for	mechanism	0.85
VAMP2	associated_with	gene	0.70
neurotransmitter release	regulates	mechanism	0.70
synaptic plasticity	associated_with	process	0.70
Ischemia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
CTSD	associated_with	gene	0.60
ATG7	activates	gene	0.60
Tubulin	associated_with	protein	0.60
Fus	activates	protein	0.60
LC3	associated_with	gene	0.60
App	activates	protein	0.60
Neuron	activates	cell_type	0.60
TUBB3	activates	entity	0.60
TUBULIN	activates	entity	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	activates	entity	0.60
SQSTM1	associated_with	gene	0.60
P62	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ACTB	activates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
MAP2	associated_with	gene	0.60
BDNF	expressed_in	gene	0.60
SHANK2	expressed_in	gene	0.60
PRKACB	expressed_in	gene	0.60
PSD95	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
JUN	activates	gene	0.60
CTSB	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60

Incoming (123)

Source	Relation	Type	Str
PSEN1	associated_with	gene	0.70
ATG5	activates	gene	0.70
CREB	expresses	gene	0.70
STING	associated_with	gene	0.70
NEURONS	activates	cell_type	0.70
HTT	activates	gene	0.70
BMP	activates	gene	0.70
BDNF	activates	gene	0.70
AIF1	regulates	gene	0.70
APP	regulates	gene	0.70
ATG7	regulates	gene	0.70
GFAP	regulates	gene	0.70
GRIN2B	associated_with	gene	0.70
IBA1	regulates	gene	0.70
BDNF	expressed_in	gene	0.70
SYN1	expresses	gene	0.70
SOD1	expresses	gene	0.70
PRKAA	activates	gene	0.60
RNA	activates	gene	0.60
rapamycin	targets	drug	0.60
AMPK	activates	gene	0.60
NEURON	activates	cell_type	0.60
CREB1	expressed_in	gene	0.60
PRKACB	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
GENES	regulates	gene	0.60
ANTIOXIDANT GENES	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DMSO	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
PSD95	expresses	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
RAGE	activates	gene	0.60
PARKIN	causes	gene	0.60
PARKIN	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
RNA	associated_with	gene	0.60
KCNH7	associated_with	gene	0.60
GBM	associated_with	gene	0.60
DIAPH3	associated_with	gene	0.60
CTSB	activates	gene	0.60
LYSOSOME	activates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AD	regulates	gene	0.60
AUTOPHAGY	regulates	pathway	0.60
AΒ	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Proteomics Differential Expression in AD CSF and Brain Tissue

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Which proteins are differentially expressed in AD CSF and brain tissue, and do t

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning SYT1 in their description or question text

No additional research found