ADAM10

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADAM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ADAM10 (A Disintegrin and Metalloproteinase 10) is the primary alpha-secretase in the non-amyloidogenic processing pathway of amyloid precursor protein (APP). Cleavage by ADAM10 occurs within the Abeta domain, preventing the formation of amyloid-beta peptides and generating the neuroprotective sAPPalpha fragment. ADAM10 is a transmembrane protein belonging to the ADAM family, widely expressed in brain tissue with particularly high activity in neurons. Genetic variants in ADAM10 have been associated with susceptibility to late-onset Alzheimer's disease, and rare pathogenic mutations (including nonsense mutations like Tyr167*) have been identified in familial AD cases. Therapeutic strategies targeting ADAM10 include promoting its activity to shift APP processing away from the amyloidogenic pathway, though no ADAM10-based therapies have yet reached clinical use. ADAM10 also processes other substrates including Notch, TNF-alpha, and ErbB4, making its biology complex and context-dependent.

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graph TD
    ADAM10["ADAM10"] -->|"biomarker for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"regulates"| Notch_pathway["Notch pathway"]
    style Notch_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"activates"| NLGN3["NLGN3"]
    style NLGN3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"associated"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"therapeutic target"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ADAM10["ADAM10"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    TREM2["TREM2"] -.->|"inhibits"| ADAM10["ADAM10"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GENES["GENES"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    CAPN1["CAPN1"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style CAPN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TTR["TTR"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style TTR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    LGALS3["LGALS3"] -->|"therapeutic target"| ADAM10["ADAM10"]
    style LGALS3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ADAM10 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold