gene

SYN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

523Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

6Debates

Summary

SYN1 encodes a phosphoprotein that regulates synaptic vesicle trafficking, neurotransmitter release, and synaptic plasticity. Critically involved in AD and PD synaptic loss.

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🧬 Gene Info

Gene Symbol	SYN1
Chromosome	Xp11.23
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Primarily neuronal
Pathways	MAPK, mapk
Ensembl ID	ENSG00000102057
GeneCards	SYN1
Human Protein Atlas	SYN1
Genomic Span	~50 kb
Exon Count	Multiple exons (13+)
Alternative Splicing	Produces multiple isoforms (I, II, III)
Associated Diseases	aging, Als, Alzheimer, Alzheimer'S Disease
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	ACTB, Actin, AD, ADAM10, AKT, ALZHEIMER
KG Connections	523 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYN1["SYN1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYN1["SYN1"] -->|"activates"| Alzheimer["Alzheimer"]
    SYN1["SYN1"] -->|"activates"| Ms["Ms"]
    SYN1["SYN1"] -->|"activates"| Ischemia["Ischemia"]
    SYN1["SYN1"] -->|"activates"| Anxiety["Anxiety"]
    SYN1["SYN1"] -->|"activates"| Inflammation["Inflammation"]
    BDNF["BDNF"] -->|"associated"| SYN1["SYN1"]
    DLG4["DLG4"] -->|"associated"| SYN1["SYN1"]
    PARP1["PARP1"] -->|"associated"| SYN1["SYN1"]
    ACTB["ACTB"] -->|"activates"| SYN1["SYN1"]
    style SYN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (271)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Alzheimer'S Disease	associated_with	disease	0.95
Neuroinflammation	associated_with	process	0.95
Cognitive Impairment	associated_with	phenotype	0.90
neurons	expressed_in	cell_type	0.90
Neuroinflammation	regulates	process	0.85
Cognitive Function	involved_in	phenotype	0.82
TNF	modulates	protein	0.80
Inflammation	activates	disease	0.75
Depression	activates	disease	0.75
Apoptosis	suppresses	process	0.75
TAU	activates	gene	0.70
VAMP2	associated_with	gene	0.70
TNF	expresses	gene	0.70
SYT1	expresses	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Synaptic Plasticity	activates	pathway	0.70
synaptic plasticity	participates_in	pathway	0.70
synaptic vesicle function	associated_with	mechanism	0.70
Autism	associated_with	disease	0.65
Epilepsy	causes	disease	0.65
Epilepsy	associated_with	disease	0.65
Als	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Inflammation	expressed_in	disease	0.65
Stroke	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Epilepsy	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Autism	causes	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	associated_with	disease	0.65
Depression	inhibits	disease	0.65
Tumor	biomarker_for	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Anxiety	activates	disease	0.65
Tumor	activates	disease	0.65
Stroke	activates	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
TAU	causes	gene	0.65
Diabetes	expressed_in	disease	0.65
Huntington	expressed_in	disease	0.65
Leukemia	therapeutic_target	disease	0.65

Incoming (252)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
h-019c56c1	targets_gene	hypothesis	0.90
MBP	stabilizes	gene	0.70
PSD95	activates	gene	0.70
GABRG2	activates	gene	0.70
GRIA1	activates	gene	0.70
GABRA1	activates	gene	0.70
CREB	expresses	gene	0.70
BDNF	expresses	gene	0.70
SOD1	expresses	gene	0.70
GRIN2A	activates	gene	0.70
AIF1	regulates	gene	0.70
APP	regulates	gene	0.70
ATG7	regulates	gene	0.70
GFAP	regulates	gene	0.70
GRIN2B	associated_with	gene	0.70
IBA1	regulates	gene	0.70
PSEN1	associated_with	gene	0.70
BDNF	interacts_with	gene	0.70
CREB	interacts_with	gene	0.70
CREB	activates	gene	0.70
h-019c56c1	targets	hypothesis	0.65
DLG4	associated_with	gene	0.65
PARP1	associated_with	gene	0.65
RAPAMYCIN	activates	drug	0.65
BDNF	associated_with	gene	0.65
ROS	expressed_in	gene	0.65
LYSOSOME	co_discussed	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
PS1	inhibits	gene	0.60
CHOLINERGIC	expresses	cell_type	0.60
NEURON	expresses	cell_type	0.60
NEURONS	expresses	cell_type	0.60
AD	enhances	gene	0.60
AΒ	activates	gene	0.60
ALZHEIMER	co_discussed	gene	0.60
AKT	activates	gene	0.60
AUTOPHAGY	co_discussed	gene	0.60
NBN	associated_with	gene	0.60
TPX2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
MDC1	associated_with	gene	0.60
ATR	associated_with	gene	0.60
MRE11	associated_with	gene	0.60
MAP1LC3B	activates	entity	0.60
MAP2	activates	entity	0.60
P62	activates	entity	0.60
SNAP25	activates	entity	0.60
SQSTM1	activates	entity	0.60
SYT1	associated_with	gene	0.60