gene

CTSB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

855Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CTSB is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Aging, Als. Connected to 311 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSB
Full Name	Cathepsin B
Chromosome	8p23.1
Subcellular Localization	** \| Lysosomes, endosomes
Molecular Weight	26 kDa
Amino Acids	339 aa
Exons	13
Pathways	Autophagy
UniProt ID	P07846
NCBI Gene ID	1508
Ensembl ID	ENSG00000164733
OMIM	116810
GeneCards	CTSB
Human Protein Atlas	CTSB
Brain	Expressed in neurons, astrocytes, and microglia throughout the CNS
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, APOPTOSIS
Known Drugs/Compounds	rapamycin, tannic acid
Interactions	ACTB, Actin, AGING, AIF1, AKT, ALS
SciDEX Hypotheses	Selective cathepsin B inhibition prevents cathepsi
KG Connections	855 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CTSB — AlphaFold P07846 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    TFEB["TFEB
Transcription Factor"]
    SLAMF7["SLAMF7
Signaling Protein"]
    CTSB["CTSB
Cathepsin B
Lysosomal Protease"]
    
    ATG12["ATG12
Autophagy Protein"]
    TPP1["TPP1
Lysosomal Enzyme"]
    GRN["GRN
Progranulin
Growth Factor"]
    
    Phagocytosis["Phagocytosis
Pathway"]
    Complement["Complement
Pathway"]
    C1QA["C1QA
Complement
Component"]
    SPP1["SPP1
Osteopontin
Inflammatory Marker"]
    
    Neurodegeneration["Neurodegeneration
Pathological Process"]
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    Huntington["Huntington's
Disease"]
    
    TFEB -->|"upregulates"| CTSB
    SLAMF7 -->|"activates"| CTSB
    
    CTSB -->|"activates"| ATG12
    CTSB -->|"associated_with"| TPP1
    CTSB -->|"activates"| GRN
    
    CTSB -->|"activates"| Phagocytosis
    CTSB -->|"activates"| Complement
    CTSB -->|"activates"| C1QA
    CTSB -->|"activates"| SPP1
    
    CTSB -->|"activates"| Neurodegeneration
    CTSB -->|"associated_with"| Alzheimer
    CTSB -->|"associated_with"| Parkinson
    CTSB -->|"associated_with"| ALS
    CTSB -->|"associated_with"| Huntington
    
    style CTSB fill:#006494
    style TFEB fill:#4a1a6b
    style SLAMF7 fill:#4a1a6b
    style ATG12 fill:#1b5e20
    style TPP1 fill:#1b5e20
    style GRN fill:#1b5e20
    style Phagocytosis fill:#1b5e20
    style Complement fill:#ef5350
    style C1QA fill:#ef5350
    style SPP1 fill:#ef5350
    style Neurodegeneration fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style Huntington fill:#5d4400

Outgoing (551)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CTSB	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Vandetanib-Induced Hepato-Cardiotoxicity	mediates	phenotype	0.95
hepato-cardiotoxicity	mediates	phenotype	0.95
MCOLN1	degrades	gene	0.90
therapeutic_target	involved_in	process	0.88
neural stem cells	activates	cell_type	0.80
MCOLN1	interacts_with	gene	0.80
Alzheimer	activates	disease	0.75
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
LAMP1	associated_with	gene	0.70
ULK1	activates	gene	0.70
LC3	interacts_with	gene	0.70
LC3	associated_with	gene	0.70
neurons	activates	cell_type	0.70
Parkinson's disease	associated_with	disease	0.70
neural stem cells	interacts_with	cell_type	0.70
GFP	interacts_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
GFP	activates	gene	0.70
APOPTOSIS	causes	phenotype	0.70
AMPK signaling	participates_in	pathway	0.70
TFEB	interacts_with	gene	0.70
CTSD	interacts_with	gene	0.70
LGALS3	interacts_with	gene	0.70
GAPDH	interacts_with	gene	0.70
P62	associated_with	gene	0.70
ULK1	interacts_with	gene	0.70
LAMP1	interacts_with	gene	0.70
SQSTM1	interacts_with	gene	0.70
Autophagy	activates	pathway	0.70
MAP1LC3B	interacts_with	gene	0.70
Ms	expressed_in	disease	0.65
Als	inhibits	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
ALS	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65

Incoming (304)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CTSB	data_in	dataset_row	0.00
proteins-cathepsin-b-protein	describes	wiki_page	1.00
ds-83b31ef18d49	data_in	dataset	1.00
Menin	regulates	protein	0.95
STAT3	upregulates	gene	0.90
SPP1	upregulates	gene	0.90
tannic acid	binds	compound	0.90
Vandetanib	upregulates	drug	0.90
TFEB	activates	gene	0.85
TFEB	upregulates	protein	0.85
ALZHEIMER DISEASE	associated_with	gene	0.80
SLAMF7	activates	gene	0.80
AMPK	activates	gene	0.80
SQSTM1	associated_with	gene	0.70
INFLAMMATION	activates	gene	0.70
AMPK	interacts_with	gene	0.70
ALZHEIMER	activates	gene	0.70
rapamycin	targets	drug	0.70
MACROPHAGE	produces	cell_type	0.65
BAG3	regulates	entity	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSH	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
LILRB2	associated_with	gene	0.60
ACE	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
KDM5A	associated_with	gene	0.60
TYRO3	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
CAMKK2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
MLKL	activates	gene	0.60
NLRP3	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
ATG12	regulates	entity	0.60
CR1	implicated_in	gene	0.60
BCL2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
C1QA	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
BCL2 FAMILY	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
AUTOPHAGY	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity