gene

TMEM59

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM59: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections

0Hypotheses

0Analyses

47Outgoing

50Incoming

0Experiments

0Debates

Summary

TMEM59 encodes transmembrane protein 59, involved in protein trafficking, glycosylation, autophagy, lysosomal function, and Alzheimer's disease pathogenesis through APP processing

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🧬 Gene Info

Gene Symbol	TMEM59
Full Name	Transmembrane Protein 59
Chromosome	9q34.3
Protein Type	Type I transmembrane protein
Function	encodes a type I transmembrane protein with a lumenal N-terminus, a single transmembrane domain, and a short cytoplasmic C-terminal tail.
Subcellular Localization	Golgi apparatus, Endoplasmic Reticulum
Pathways	pathway: #### Golgi Function
UniProt ID	Q9H0M0
NCBI Gene ID	9528
Ensembl ID	ENSG00000115616
OMIM	610024
GeneCards	TMEM59
Human Protein Atlas	TMEM59
Signal peptide	N-terminal signal sequence for entry into the secretory pathway
Single transmembrane helix	Anchors the protein in membrane compartments
Associated Diseases	Als, Alzheimer, Parkinson
Interactions	ABP, ALZHEIMER, APOE, APP, ATG16L1, BACE1
KG Connections	106 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TMEM59 — AlphaFold Q9H0M0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TMEM59 Gene

gene · 1377 words

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Pathway Diagram

graph TD
    TMEM59["TMEM59"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    SFPQ["SFPQ"]
    CCT4["CCT4"]
    CALB1["CALB1"]
    SORL1["SORL1"]
    IGF2R["IGF2R"]
    COPA["COPA"]
    STXBP3["STXBP3"]
    RNF14["RNF14"]
    IDS["IDS"]
    SYNCRIP["SYNCRIP"]
    SSBP1["SSBP1"]
    PRDX3["PRDX3"]
    APP["APP"]
    ALZHEIMER["ALZHEIMER"]
    APOE["APOE"]
    SYNE2["SYNE2"]
    SMARCB1["SMARCB1"]
    ULK2["ULK2"]
    TMEM59 -.-|"associated"| Alzheimer
    TMEM59 -.-|"associated"| Als
    TMEM59 -.-|"associated"| SFPQ
    TMEM59 -.-|"associated"| CCT4
    TMEM59 -.-|"associated"| CALB1
    TMEM59 -.-|"associated"| SORL1
    TMEM59 -.-|"associated"| IGF2R
    TMEM59 -.-|"associated"| COPA
    TMEM59 -.-|"associated"| STXBP3
    TMEM59 -.-|"associated"| RNF14
    IDS -.-|"associated"| TMEM59
    SYNCRIP -.-|"associated"| TMEM59
    SSBP1 -.-|"associated"| TMEM59
    PRDX3 -.-|"associated"| TMEM59
    APP -.-|"associated"| TMEM59
    ALZHEIMER -.-|"associated"| TMEM59
    APOE -.-|"associated"| TMEM59
    SYNE2 -.-|"associated"| TMEM59
    SMARCB1 -.-|"associated"| TMEM59
    ULK2 -.-|"associated"| TMEM59
    style TMEM59 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (47)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
PRDX3	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
IDS	associated_with	gene	0.60
TOMM20	activates	gene	0.60
neuroinflammation	activates	disease	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APP	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
APOE	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
Parkinson	associated_with	disease	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
COPA	associated_with	gene	0.60
Igf	associated_with	protein	0.60
microglia	expressed_in	cell_type	0.55
ALZHEIMER'S	interacts_with	concept	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50
CALB1	interacts_with	gene	0.50
RNF14	interacts_with	gene	0.50
CCT4	interacts_with	gene	0.50
ULK2	interacts_with	gene	0.50
STXBP3	interacts_with	gene	0.50
SORL1	interacts_with	gene	0.50
SFPQ	interacts_with	protein	0.50
IGF2R	interacts_with	protein	0.50
SYNCRIP	interacts_with	concept	0.50
TOMM20	co_expressed_with	gene	0.50
COPA	interacts_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50

Incoming (59)

Source	Relation	Type	Str
IDS	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
APP	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60
SYNCRIP	interacts_with	gene	0.60
CCT4	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
APP	interacts_with	gene	0.60
CALB1	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
PRDX3	interacts_with	gene	0.60
RNF14	interacts_with	gene	0.60
DMSO	activates	gene	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
NLR	activates	gene	0.60
ABP	activates	gene	0.60
ATG16L1	activates	gene	0.60
BCL2	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CASP3	activates	gene	0.60
GAPDH	activates	gene	0.60
HTT	activates	gene	0.60
LC3	activates	gene	0.60
MFF	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
NLRX1	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
TIMM23	activates	gene	0.60
APOE	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
APOE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TMEM59 in their description or question text

No additional research found