gene

ACTB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACTB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1093Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ACTB is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, regulates. Associated with AD, ADH, ALI. Connected to 568 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ACTB
Full Name	Beta-Actin
Chromosome	7p22.1
Function	is a globular protein with a molecular weight of approximately 42 kDa.
Molecular Weight	42 kDa
Exons	6
Pathways	Autophagy, Chaperone, Mapk, Mtor, Oxidative Stress
UniProt ID	P60709
NCBI Gene ID	81
Ensembl ID	ENSG00000075624
OMIM	102630
GeneCards	ACTB
Human Protein Atlas	ACTB
Associated Diseases	AD, ADH, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	rapamycin, statins
Interactions	4E-BP1, ABCA1, ABCG1, ACTG1, Actin, AGING
KG Connections	1093 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ACTB — AlphaFold P60709 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ACTB Gene

gene · 1725 words

→

ACTB Protein

protein · 951 words

→

Pathway Diagram

flowchart TD
    ACTB(["ACTB"])
    Autophagy["Autophagy"]
    AUTOPHAGY(["AUTOPHAGY"])
    Als["Als"]
    SQSTM1(["SQSTM1"])
    PPARGC1A(["PPARGC1A"])
    ATG14(["ATG14"])
    LAMP1(["LAMP1"])
    LC3(["LC3"])
    P62(["P62"])
    EGFR(["EGFR"])
    ALS(["ALS"])
    BECN1(["BECN1"])

    ACTB -->|"associated with"| Autophagy
    ACTB -->|"associated with"| AUTOPHAGY
    ACTB -->|"interacts with"| Als
    ACTB -->|"regulates"| SQSTM1
    ACTB -->|"regulates"| PPARGC1A
    ACTB -->|"associated with"| ATG14
    ACTB -->|"activates"| LAMP1
    ACTB -->|"activates"| LC3
    ACTB -->|"regulates"| P62
    ACTB -->|"activates"| P62
    ACTB -->|"associated with"| P62
    ACTB -->|"interacts with"| EGFR
    ACTB -->|"interacts with"| ALS
    BECN1 -->|"associated with"| ACTB
    SQSTM1 -->|"activates"| ACTB

    style ACTB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (813)

Target	Relation	Type	Str
neural stem cells	activates	cell_type	0.90
oxidative stress response	participates_in	pathway	0.90
neural stem cells	regulates	cell_type	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
RNA	activates	gene	0.80
BECN1	regulates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
Autophagy	associated_with	pathway	0.80
Als	interacts_with	disease	0.75
ALS	interacts_with	gene	0.70
P62	activates	gene	0.70
EGFR	interacts_with	gene	0.70
ATG14	associated_with	gene	0.70
P62	regulates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
neurons	regulates	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
neurons	activates	cell_type	0.70
frontotemporal dementia	regulates	disease	0.70
ATG7	regulates	gene	0.70
PPARGC1A	regulates	gene	0.70
RNA	regulates	gene	0.70
ALS	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
ATP	activates	gene	0.70
frontotemporal dementia	activates	disease	0.70
SQSTM1	regulates	gene	0.70
ULK1	regulates	gene	0.70
LC3	regulates	gene	0.70
LC3	activates	gene	0.70
neurodegeneration	regulates	disease	0.70
LAMP1	activates	gene	0.70
P62	associated_with	gene	0.70
Als	activates	disease	0.65
Infection	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
ALS	inhibits	disease	0.65
Ms	activates	disease	0.65
Senescence	regulates	disease	0.65
Tumor	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (280)

Source	Relation	Type	Str
genes-actb	describes	wiki_page	0.95
rapamycin	targets	drug	0.80
SQSTM1	activates	gene	0.70
TP53	interacts_with	gene	0.70
BECN1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
WIPI2	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
P62	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
HTT	associated_with	gene	0.60
SETX	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
TUBB3	regulates	gene	0.60
H2AX	associated_with	gene	0.60
ASC	activates	gene	0.60
AIM2	activates	gene	0.60
VAMP8	activates	gene	0.60
ULK1	activates	gene	0.60
CTSB	activates	gene	0.60
ATP6V0D1	activates	gene	0.60
NLRP3	activates	gene	0.60
CDC42	interacts_with	gene	0.60
STROKE	regulates	gene	0.60
RNA	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
ATG	regulates	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
MIRNAS	regulates	gene	0.60
TJP1	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
LYSOSOME	associated_with	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
ALS	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
TLR	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACTB in their description or question text

No additional research found