concept

LOX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

672Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

2Experiments

1Debates

Summary

LOX is a concept in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with AD, ALS, AMI. Connected to 270 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	LOX
Key Genes/Proteins	4E-BP1, ABCG1, ACSL4, Actin, ACTIN, AGING
Related Diseases	AD, Aging
Related Pathways	Akt
Linked Hypotheses	4 hypotheses

🔮 Predicted Structure: LOX — AlphaFold B7ZAJ4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

ALOX15 - Arachidonate 15-Lipoxygenase

gene · 840 words

→

ALOX15 Protein

protein · 746 words

→

Pathway Diagram

graph TD
    LOX["LOX"]
    LOX -->|"expressed in"| macrophages["macrophages"]
    LOX -->|"regulates"| OLFML3["OLFML3"]
    LOX -->|"activates"| macrophage["macrophage"]
    LOX -->|"activates"| ITGB1["ITGB1"]
    LOX -.biomarker for.-> glioblastoma_multiforme["glioblastoma multiforme"]
    LOX -->|"activates"| _1_integrin["beta1 integrin"]
    LOX -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    LOX -->|"interacts"| Als["Als"]
    h_82922df8["h-82922df8"] -->|"targets"| LOX
    YAP1["YAP1"] -->|"activates"| LOX
    LOXL1_4["LOXL1-4"] -->|"interacts"| LOX
    ACTB["ACTB"] -->|"interacts"| LOX
    P2RY12["P2RY12"] -->|"inhibits"| LOX
    APOA1["APOA1"] -->|"interacts"| LOX
    ULK1["ULK1"] -->|"interacts"| LOX
    ATG5["ATG5"] -->|"interacts"| LOX
    EIF4EBP1["EIF4EBP1"] -->|"interacts"| LOX
    LC3["LC3"] -->|"interacts"| LOX

Outgoing (466)

Target	Relation	Type	Str
Macrophages	expressed_in	cell_type	0.95
Cancer Progression	involved_in	process	0.95
Cancer Progression	promotes	process	0.95
Glioma	associated_with	disease	0.92
neuronal cell	expressed_in	cell_type	0.90
overall survival	risk_factor_for	phenotype	0.90
oxidative stress response	participates_in	pathway	0.90
tumor progression	promotes	process	0.90
Overall Survival	biomarker_for	phenotype	0.90
Macrophage Infiltration	regulates	process	0.90
Tumor Progression	correlates_with	process	0.90
Poor Survival	risk_factor_for	phenotype	0.90
Cancer Prognosis	biomarker_for	phenotype	0.90
Therapeutic Response	associated_with	phenotype	0.85
Alzheimer's Disease	implicated_in	disease	0.85
Glioma	biomarker_for	disease	0.85
Tumor	activates	disease	0.85
Cancer	activates	disease	0.85
Alzheimer's Disease	therapeutic_target	disease	0.80
lysyl_oxidase	encodes	protein	0.80
Alzheimer	regulates	disease	0.75
Alzheimer	activates	disease	0.75
Diabetes	activates	disease	0.75
Cardiovascular	activates	disease	0.75
Inflammation	activates	disease	0.75
Autoimmune	activates	disease	0.75
drug sensitivity	associated_with	phenotype	0.75
macrophages	expressed_in	cell_type	0.70
ITGB1	activates	protein	0.70
INFLAMMATION	activates	gene	0.70
macrophage	activates	cell_type	0.70
macrophage	regulates	cell_type	0.70
OLFML3	regulates	protein	0.70
β1 integrin	activates	protein	0.70
macrophage	expressed_in	cell_type	0.70
AKT	inhibits	gene	0.70
glioblastoma multiforme	biomarker_for	disease	0.70
hippocampus	expressed_in	brain_region	0.70
Tumor	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Cerebral Amyloid Angiopathy	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	contributes_to	disease	0.65
ALS	activates	disease	0.65
Dementia	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	regulates	disease	0.65
Depression	regulates	disease	0.65

Incoming (206)

Source	Relation	Type	Str
h-82922df8	targets_gene	hypothesis	0.90
LOXL3	interacts_with	gene	0.80
Aβ42 oligomers	modulates	compound	0.80
h-82922df8	targets	hypothesis	0.80
APP	associated_with	gene	0.75
YAP1	activates	protein	0.70
MAO-A	interacts_with	protein	0.70
PI3K	inhibits	gene	0.70
ALZHEIMER	regulates	gene	0.70
CYTOKINES	activates	gene	0.70
ALZHEIMER	activates	gene	0.70
LOXL1-4	interacts_with	gene	0.64
LC3	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
APOE	inhibits	gene	0.60
PTEN	regulates	gene	0.60
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
CYP450	regulates	gene	0.60
LOXL1	regulates	gene	0.60
LOXL2	activates	gene	0.60
RNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
LOXL1	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
AND	regulates	gene	0.60
ALOX15	associated_with	gene	0.60
ALOX15	regulates	gene	0.60
SPP1	associated_with	gene	0.60
BIN1	regulates	gene	0.60
P62	interacts_with	gene	0.60
AKT	inhibits	gene	0.60
VDR	regulates	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
LOXL1-4	stabilizes	gene	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
STAT3	activates	gene	0.60
NRF2	activates	gene	0.60
senolytics	associated_with	compound	0.60
quercetin	associated_with	compound	0.60
MICROGLIA	activates	gene	0.60
AND	associated_with	gene	0.60
AMYLOID	therapeutic_target	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.777	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th	0.695	neurodegeneration	Neuroinflammation resolution mechanisms
ALOX15 Inhibition Combined with Selenium Augmentation for Sy	0.580	-	Ferroptosis in ALS and motor neuron dise
oxLDL/LOX-1/ROS Signaling Induces P2RY12 via Nrf2 Activation	0.550	neurodegeneration	What determines P2RY12 receptor expressi

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.841

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Bioinformatics analysis and hub gene identification	exploratory	Alzheimer's disease	0.800	0.00	computational analysis of tran	proposed	N/A
s:** - ALOX15 overexpression in healthy astrocytes should be protectiv	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924]	Cai W, Liu L, Shi X, Liu Y, Wang J, Fang	Circulation	2023	1
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829]	Tong J, Lan XT, Zhang Z, Liu Y, Sun DY,	Acta Pharmacol Sin	2023	1
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859]	Zhang H, Deng T, Liu R, Ning T, Yang H,	Mol Cancer	2020	1
Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102]	Zhao Y, Bhattacharjee S, Jones BM, Hill	Mol Neurobiol	2014	1
ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595]	Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z	Functional & integrative genom	2026	0
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658]	Hou G, Luan J, Xu X, Qin J, Ma S et al.	Adv Sci (Weinh)	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126]	Li X, Xu Z, Ju P, Dong M, Wang Y et al.	Phytomedicine	2026	0
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540]	Man GCW, Borchert A, Zhang T, Hung SW, K	Antioxidants (Basel, Switzerla	2026	0
ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922]	Hilman A, Ishii Y, Wijatniko BD, Rini DM	FASEB journal : official publi	2026	0
Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293]	Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu	FASEB journal : official publi	2026	0
FGF21 promotes the resolution of inflammation through the ALOX15/SPM pathway in [PMID:41913238]	Chenxi Shen; Yuan Cao; Jinling Wei; Xiny	Respiratory research	2026	0
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic do [PMID:39882747]	Deng S, Cao H, Li T, Wang X, Meng J, Zen	Gut microbes	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early [PMID:39362839]	Yang X, Chen H, Shen W, Chen Y, Lin Z, Z	Nature communications	2024	0
Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer ba [PMID:37469520]	Shen L, Huang H, Li J, Chen W, Yao Y, Hu	Frontiers in immunology	2023	0
A survey of human brain transcriptome diversity at the single cell level. [PMID:26060301]	["Darmanis S", "Sloan S", "Zhang Y", "En	Proceedings of the National Ac	2015	0
Exploring sRNA-mediated gene silencing mechanisms using artificial small RNAs de [PMID:23393193]	["Park H", "Bak G", "Kim S", "Lee Y"]	Nucleic acids research	2013	0

Debates (1)

Multi-agent debates referencing this entity

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06