gene

TOLLIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOLLIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

196Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TOLLIP is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with AD, ALI, ALS. Connected to 104 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TOLLIP
Full Name	Toll-Interacting Protein
Chromosome	11p15.5
Function	It binds and inhibits IL-1 receptor-associated kinase 1 (IRAK1), preventing its auto-phosphorylation and blocking downstream NF-kappaB and MAPK cascades.
Molecular Weight	30 kDa
Amino Acids	274 aa
Exons	6
Pathways	MAPK
UniProt ID	Q9H0E2
NCBI Gene ID	54472
Ensembl ID	ENSG00000078902
OMIM	606277
GeneCards	TOLLIP
Human Protein Atlas	TOLLIP
Associated Diseases	AD, ALI, Als, AMI, amyotrophic lateral sclerosis, degenerative disease
Interactions	ACTB, Actin, ALS, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	196 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TOLLIP — AlphaFold Q9H0E2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TOLLIP — Toll-Interacting Protein

gene · 838 words

→

TOLLIP Protein

protein · 568 words

→

Pathway Diagram

graph TD
    TOLLIP["TOLLIP"]
    TOLLIP -->|"inhibits"| CGAS["CGAS"]
    TOLLIP -->|"participates in"| selective_autophagy["selective autophagy"]
    TOLLIP -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TOLLIP -->|"interacts"| Dementia["Dementia"]
    TOLLIP -->|"interacts"| Als["Als"]
    TOLLIP -->|"inhibits"| Ms["Ms"]
    TOLLIP -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    TOLLIP -->|"interacts"| Ftd["Ftd"]
    TOLLIP -->|"regulates"| Cancer["Cancer"]
    ACTB["ACTB"] -->|"interacts"| TOLLIP
    OPTN["OPTN"] -->|"interacts"| TOLLIP
    ULK1["ULK1"] -->|"interacts"| TOLLIP
    SMCR8["SMCR8"] -->|"interacts"| TOLLIP
    CALCOCO2["CALCOCO2"] -->|"interacts"| TOLLIP
    LC3["LC3"] -->|"interacts"| TOLLIP
    BECN1["BECN1"] -->|"interacts"| TOLLIP
    C9ORF72["C9ORF72"] -->|"interacts"| TOLLIP
    NBR1["NBR1"] -->|"interacts"| TOLLIP
    G3BP1["G3BP1"] -->|"interacts"| TOLLIP

Outgoing (107)

Target	Relation	Type	Str
CGAS	inhibits	protein	1.00
selective autophagy	participates_in	pathway	0.90
ubiquitinated CGAS	binds_to	protein	0.90
Atherosclerosis	therapeutic_target	disease	0.65
Infection	causes	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Ftd	interacts_with	disease	0.65
Viral Infection	causes	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Als	causes	disease	0.65
Dementia	interacts_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Infection	inhibits	disease	0.65
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NDP52	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
RNA	interacts_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
SQSTM1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Complement	therapeutic_target	pathway	0.60
C9ORF72	interacts_with	gene	0.60
frontotemporal dementia	activates	disease	0.60
NBR1	interacts_with	gene	0.60
ALS	activates	disease	0.60
Immune Response	regulates	pathway	0.60
ABIN1	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
Interferon Signaling	causes	pathway	0.60
UBIQUITIN	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
Mtor	therapeutic_target	pathway	0.60
OPTN	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
SMCR8	interacts_with	gene	0.60
SYK	therapeutic_target	gene	0.60
VCP	regulates	gene	0.60

Incoming (89)

Source	Relation	Type	Str
HSPA8	interacts_with	gene	0.70
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
SMCR8	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
LYSOSOME	associated_with	gene	0.60
ACTB	activates	entity	0.60
BECN1	activates	entity	0.60
C9ORF72	activates	entity	0.60
CALCOCO2	activates	entity	0.60
FUS	activates	entity	0.60
G3BP1	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
SMCR8	activates	entity	0.60
SQSTM1	activates	entity	0.60
TAX1BP1	activates	entity	0.60
TRIM21	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALS	interacts_with	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
ALS	activates	entity	0.60
FTD	activates	entity	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
RNA	activates	gene	0.60
CGAS	inhibits	gene	0.60
FUS	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TOLLIP in their description or question text

No additional research found