protein

4E-BP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about 4E-BP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

12Outgoing

25Incoming

0Experiments

0Debates

Summary

Eukaryotic Translation Initiation Factor 4E Binding Protein 1 - key regulator of cap-dependent translation with critical roles in neurodegeneration

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🔬 Protein Info

Gene Symbol	4E-BP1
Aliases	Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Molecular Weight	12.5 kDa
Amino Acids	118 aa
Pathways	Cholesterol, CHOLESTEROL
Interactions	ABCA1, ABCG1, ACTB, AMPK, APOA1, ATG5
KG Connections	37 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

4E-BP1 Protein

protein · 1881 words

→

EIF4EBP1 Protein (4E-BP1)

protein · 526 words

→

Pathway Diagram

graph TD
    n_4E_BP1["4E-BP1"]
    n_4E_BP1 -->|"activates"| Genes["Genes"]
    n_4E_BP1 -->|"activates"| AMPK["AMPK"]
    n_4E_BP1 -->|"activates"| MAP1LC3["MAP1LC3"]
    n_4E_BP1 -->|"activates"| Cholesterol["Cholesterol"]
    n_4E_BP1 -->|"activates"| atherosclerosis["atherosclerosis"]
    n_4E_BP1 -->|"activates"| AUTOPHAGOSOME["AUTOPHAGOSOME"]
    TSC1_TSC2_complex["TSC1-TSC2 complex"] -->|"activates"| n_4E_BP1
    ABCA1["ABCA1"] -->|"activates"| n_4E_BP1
    ABCG1["ABCG1"] -->|"activates"| n_4E_BP1
    ACTB["ACTB"] -->|"activates"| n_4E_BP1
    APOA1["APOA1"] -->|"activates"| n_4E_BP1
    Autophagy["Autophagy"] -->|"activates"| n_4E_BP1
    ULK1["ULK1"] -->|"activates"| n_4E_BP1
    P2RY12["P2RY12"] -->|"activates"| n_4E_BP1

Outgoing (12)

Target	Relation	Type	Str
AMPK	activates	protein	0.50
MAP1LC3	activates	gene	0.50
Cholesterol	activates	pathway	0.50
atherosclerosis	activates	disease	0.50
AUTOPHAGOSOME	activates	concept	0.50
CHOLESTEROL	co_discussed	pathway	0.40
MAP1LC3	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
LOX	co_discussed	gene	0.40
SQSTM1	co_discussed	gene	0.40
P62	co_discussed	protein	0.40
ULK1	co_discussed	gene	0.40

Incoming (25)

Source	Relation	Type	Str
TSC1-TSC2 complex	activates	protein	0.90
ABCA1	activates	gene	0.50
ABCG1	activates	gene	0.50
ACTB	activates	gene	0.50
APOA1	activates	gene	0.50
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
P2RY12	activates	gene	0.50
SQSTM1	activates	gene	0.50
EIF4EBP1	activates	gene	0.50
ATG5	activates	gene	0.50
P2RY12	co_discussed	gene	0.40
ATHEROSCLEROSIS	co_discussed	disease	0.40
ABCA1	co_discussed	gene	0.40
ABCG1	co_discussed	gene	0.40
ACTB	co_discussed	gene	0.40
ACTIN	co_discussed	protein	0.40
ALS	co_discussed	disease	0.40
LYSOSOME	co_discussed	gene	0.40
AMPK	co_discussed	protein	0.40
APOA1	co_discussed	gene	0.40
ATG5	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
RELA	co_discussed	gene	0.40
EIF4EBP1	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning 4E-BP1 in their description or question text

No additional research found