concept

SPINAL MUSCULAR ATROPHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPINAL MUSCULAR ATROPHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	SPINAL MUSCULAR ATROPHY
Key Genes/Proteins	TARDBP, TH
Related Pathways	DNA DAMAGE RESPONSE

Pathway Diagram

graph TD
    SPINAL_MUSCULAR_ATROPHY["SPINAL MUSCULAR ATROPHY"]
    SPINAL_MUSCULAR_ATROPHY -->|"regulates"| Fibroblast["Fibroblast"]
    SPINAL_MUSCULAR_ATROPHY -->|"target for"| Cholesterol["Cholesterol"]
    SPINAL_MUSCULAR_ATROPHY -->|"target for"| Neuron["Neuron"]
    SPINAL_MUSCULAR_ATROPHY -->|"expressed in"| Apoptosis["Apoptosis"]
    Gene_Therapy["Gene Therapy"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
    Nursinersen["Nursinersen"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
    RNA["RNA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    ALS["ALS"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    OVERVIEW["OVERVIEW"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    DEMENTIA["DEMENTIA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    HUNTINGTON["HUNTINGTON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
    PARKINSON["PARKINSON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY

Outgoing (63)

Target	Relation	Type	Str
ferroptosis	involves	pathway	0.90
lipid metabolism	involves	pathway	0.90
macrophages	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
neural stem cells	affects	cell_type	0.90
neurons	affects	cell_type	0.90
endosome	disrupts	organelle	0.90
cerebellum	affects	brain_region	0.80
astrocytes	affects	cell_type	0.80
microglia	affects	cell_type	0.80
pyroptosis	involves	pathway	0.80
hippocampus	affects	brain_region	0.80
B cells	affects	cell_type	0.80
T cells	affects	cell_type	0.80
necroptosis	involves	pathway	0.80
Golgi apparatus	disrupts	organelle	0.80
TGF-beta signaling	involves	pathway	0.80
blood-brain barrier	affects	brain_region	0.70
oligodendrocytes	affects	cell_type	0.70
glutamate signaling	involves	pathway	0.70
spinal cord	affects	brain_region	0.70
cortex	affects	brain_region	0.70
axon	disrupts	organelle	0.70
Purkinje cells	affects	cell_type	0.60
nitric oxide	disrupts	neurotransmitter	0.60
autophagy pathway	involves	pathway	0.60
substantia nigra	affects	brain_region	0.60
monocytes	affects	cell_type	0.60
dendritic cells	affects	cell_type	0.60
PI3K-AKT-mTOR signaling	involves	pathway	0.60
Wnt signaling	involves	pathway	0.60
adenosine	disrupts	neurotransmitter	0.60
thalamus	affects	brain_region	0.60
hypothalamus	affects	brain_region	0.60
insulin signaling	involves	pathway	0.60
insulin receptor	involves	receptor	0.60
endothelial cells	affects	cell_type	0.60
mast cells	affects	cell_type	0.60
synaptic vesicle	disrupts	organelle	0.60
choroid plexus	affects	brain_region	0.60
white matter	affects	brain_region	0.60
synaptic plasticity	involves	pathway	0.60
oxidative stress response	involves	pathway	0.60
epigenetic regulation	involves	pathway	0.60
temporal lobe	affects	brain_region	0.60
Fibroblast	regulates	cell_type	0.55
Neuron	associated_with	cell_type	0.55
Er Stress	associated_with	pathway	0.55
Cerebellum	associated_with	brain_region	0.55
Apoptosis	expressed_in	pathway	0.55

Incoming (240)

Source	Relation	Type	Str
Gene Therapy	treats	process	0.95
Nursinersen	treats	drug	0.90
LDL	associated_with	gene	0.80
MAPT	biomarker_for	gene	0.80
GFAP	biomarker_for	gene	0.80
DNA	associated_with	gene	0.80
CRISPR-Q system	therapeutic_target	compound	0.80
IL6	regulates	gene	0.70
RNA	interacts_with	gene	0.70
ALS	associated_with	gene	0.70
DDC	biomarker_for	gene	0.70
RNA	associated_with	gene	0.70
LDLR	associated_with	gene	0.70
TNF	activates	gene	0.70
TNF	associated_with	gene	0.70
RNA	activates	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.65
CCNF	expressed_in	gene	0.65
MAPT	associated_with	gene	0.65
HNRNPA2B1	associated_with	gene	0.65
SMN	associated_with	gene	0.65
TIA1	associated_with	gene	0.65
PLIN4	expressed_in	gene	0.65
HNRNPA1	associated_with	gene	0.65
CDKN1A	expressed_in	gene	0.65
ATXN2	associated_with	gene	0.65
CNTN4	expressed_in	gene	0.65
TDP-43	associated_with	gene	0.65
BID	expressed_in	gene	0.65
MAP1LC3	associated_with	gene	0.65
DEMENTIA	therapeutic_target	gene	0.65
HUNTINGTON	therapeutic_target	gene	0.65
TBC1D24	expressed_in	gene	0.65
PARKINSON	therapeutic_target	gene	0.65
HUNTINGTIN	associated_with	gene	0.65
SMN2	interacts_with	gene	0.65
SMN1	causes	gene	0.65
ALDH1A2	contributes_to	gene	0.65
SMN	causes	gene	0.65
DNAJB1	inhibits	gene	0.65
HSP70	inhibits	gene	0.65
DNAJB2	inhibits	gene	0.65
DNAJA1	inhibits	gene	0.65
DNAJB6	inhibits	gene	0.65
GABA	associated_with	gene	0.65
MTORC1	associated_with	gene	0.65
NEURON	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
SMN	interacts_with	gene	0.65
RNA	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPINAL MUSCULAR ATROPHY in their description or question text

No additional research found