gene

PRDX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

210Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PRDX6 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, contributes to. Associated with Aging, Als, Cancer. Connected to 100 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	PRDX6
Full Name	Peroxiredoxin 6
Chromosome	1q25.1
Function	is a unique member of the peroxiredoxin family with distinctive dual enzyme activities that set it apart from other peroxiredoxins.
Primary Expression	Brain, Liver, Lung, Heart, Kidney
Molecular Weight	25 kDa
Amino Acids	224 aa
Exons	9
Pathways	Mitophagy
UniProt ID	P30041
NCBI Gene ID	9588
Ensembl ID	ENSG00000119004
OMIM	603351
GeneCards	PRDX6
Human Protein Atlas	PRDX6
Associated Diseases	Aging, Als, Cancer, Cardiovascular, Ms, neuroinflammation
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, ASTROCYTE, ASTROCYTES
KG Connections	210 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRDX6 — AlphaFold P30041 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

prdx6

gene · 2449 words

→

Pathway Diagram

graph TD
    PRDX6["PRDX6"]
    PRDX6 -->|"activates"| Cancer["Cancer"]
    PRDX6 -->|"inhibits"| Hepatitis["Hepatitis"]
    PRDX6 -->|"inhibits"| Carcinoma["Carcinoma"]
    PRDX6 -->|"inhibits"| Als["Als"]
    PRDX6 -->|"inhibits"| Cirrhosis["Cirrhosis"]
    PRDX6 -->|"inhibits"| Ms["Ms"]
    PRDX6 -->|"contributes to"| Tumor["Tumor"]
    PRDX6 -->|"activates"| MAPK14["MAPK14"]
    PRDX6 -->|"activates"| BECN1["BECN1"]
    PRDX6 -->|"activates"| TNF["TNF"]
    CKB["CKB"] -->|"interacts"| PRDX6
    P38["P38"] -->|"activates"| PRDX6
    MAP1LC3["MAP1LC3"] -->|"activates"| PRDX6
    IL1B["IL1B"] -->|"activates"| PRDX6
    PRDX1["PRDX1"] -->|"activates"| PRDX6
    TRAF6["TRAF6"] -->|"activates"| PRDX6
    CHUK["CHUK"] -->|"activates"| PRDX6
    PARKIN["PARKIN"] -->|"inhibits"| PRDX6
    TLR4["TLR4"] -->|"activates"| PRDX6
    UBIQUITIN["UBIQUITIN"] -->|"activates"| PRDX6

Outgoing (131)

Target	Relation	Type	Str
Neuroinflammation	associated_with	process	0.95
PARKIN	interacts_with	protein	0.90
mitophagy	inhibits	process	0.90
M1 Microglia	regulates	phenotype	0.85
Astrocytes	modulates	cell_type	0.80
Inflammation	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Stroke	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Hepatocellular Carcinoma	inhibits	disease	0.65
Cancer	activates	disease	0.65
Cirrhosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Infection	activates	disease	0.65
Invasion	activates	pathway	0.60
MT1A	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
MAPK1	interacts_with	gene	0.60
MMP1	interacts_with	gene	0.60
CRYAB	interacts_with	gene	0.60
CATHEPSINS	interacts_with	gene	0.60
MAP1LC3	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CANCER	activates	gene	0.60
HSPB1	associated_with	gene	0.60
PRDX1	activates	gene	0.60
PRDX3	contributes_to	gene	0.60
SOD2	contributes_to	gene	0.60
Ferroptosis	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Mapk	contributes_to	pathway	0.60
STROKE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ROS	activates	gene	0.60
multiple sclerosis	inhibits	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
blood-brain barrier	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
OXIDATIVE STRESS	associated_with	gene	0.60

Incoming (79)

Source	Relation	Type	Str
MIZ1	binds_to	protein	0.95
CKB	interacts_with	gene	0.80
ALZHEIMER	interacts_with	gene	0.60
NFE2L2	associated_with	gene	0.60
MT1A	associated_with	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
IL6	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
MMP1	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
NF-KB	activates	gene	0.60
NFKB	activates	gene	0.60
G6PD	associated_with	gene	0.60
PARKIN	inhibits	gene	0.60
SLC7A11	associated_with	gene	0.60
TNF	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
CANCER	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ROS	activates	gene	0.60
AND	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
PRDX1	activates	gene	0.60
TRAF6	activates	gene	0.60
CHUK	activates	gene	0.60
TLR4	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MAPK14	activates	gene	0.60
TNF	activates	gene	0.60
MAP3K7	activates	gene	0.60
LC3	activates	gene	0.60
BECN1	activates	gene	0.60
ECSIT	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
TAK1	activates	gene	0.60
RELA	activates	gene	0.60
CRYAB	interacts_with	gene	0.60
AGING	associated_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
P38	activates	gene	0.60
IL1B	activates	gene	0.60
TSC1	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRDX6 in their description or question text

No additional research found