gene 1,951 words KG: TIMM23
Contents

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

🧬 Gene Info
Gene SymbolTIMM23
Full NameTranslocase of Inner Mitochondrial Membrane 23
Chromosome10q11.21.
FunctionThe TIM23 complex operates in conjunction with the TOM (Translocase of Outer Mitochondrial Membrane) complex, which recognizes and imports precursor proteins across the outer membrane.
Primary ExpressionHigh in brain, heart, muscle, kidney
Amino Acids222 aa
PathwaysMitophagy
UniProt IDO00231
NCBI Gene ID10098
Ensembl IDENSG00000132268
GeneCardsTIMM23
Human Protein AtlasTIMM23
Associated DiseasesParkinson
InteractionsABP, AMPK, ATG16L1, BCL2, BECN1, BNIP3
KG Connections84 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (16)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Membrane Cholesterol Gradient Modulators
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (12)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
PINK1 (PTEN-Induced Kinase 1)
entity · KG edge: interacts_with
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: interacts_with
BECN1 Gene
gene · KG edge: inhibits
BNIP3 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

OPTN interacts_with TIMM23
PINK1 interacts_with TIMM23
TOMM20 interacts_with TIMM23
TIMM23 interacts_with CALCOCO2
TIMM23 interacts_with PARKIN
TIMM23 interacts_with PRKN
TIMM23 interacts_with NDP52
TIMM23 interacts_with HSPD1
BNIP3 inhibits TIMM23
VDAC1 inhibits TIMM23

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