concept

DMSO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DMSO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

334Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DMSO is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 122 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DMSO
Key Genes/Proteins	ABL1, ABP, ACTB, Actin, ADAM10, AIF1
Related Diseases	Aging, Als, Alzheimer, Alzheimer Disease, Alzheimer's disease
Related Pathways	Akt

Pathway Diagram

graph TD
    DMSO["DMSO"]
    DMSO -->|"causes"| CASP3["CASP3"]
    DMSO -->|"activates"| Ms["Ms"]
    DMSO -->|"expressed in"| Tumor["Tumor"]
    DMSO -->|"activates"| Leukemia["Leukemia"]
    DMSO -->|"target for"| Inflammation["Inflammation"]
    DMSO -->|"target for"| Alzheimer["Alzheimer"]
    DMSO -->|"target for"| Als["Als"]
    DMSO -->|"target for"| Neuroinflammation["Neuroinflammation"]
    DMSO -->|"activates"| Ischemia["Ischemia"]
    DMSO -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CTSD["CTSD"] -->|"activates"| DMSO
    CLN3["CLN3"] -->|"target for"| DMSO
    MTOR["MTOR"] -->|"activates"| DMSO
    P62["P62"] -->|"activates"| DMSO
    TUBULIN["TUBULIN"] -->|"activates"| DMSO
    JUN["JUN"] -->|"activates"| DMSO
    LC3["LC3"] -->|"activates"| DMSO
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| DMSO
    SQSTM1["SQSTM1"] -->|"activates"| DMSO
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"activates"| DMSO

Outgoing (220)

Target	Relation	Type	Str
CASP3	causes	gene	0.70
MAP1LC3	associated_with	gene	0.70
LC3	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Autophagy	associated_with	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Leukemia	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	inhibits	disease	0.65
ASTROCYTES	inhibits	gene	0.60
DYRK1A	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
Tau Phosphorylation	inhibits	pathway	0.60
CLN3	therapeutic_target	gene	0.60
Neuron	inhibits	cell_type	0.60
MDH1	activates	gene	0.60
IDH1	activates	gene	0.60
Neutrophil	activates	cell_type	0.60
Alzheimer's disease	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
LAMP1	activates	gene	0.60
ATG7	associated_with	gene	0.60
MAP1LC3B	activates	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
SYT1	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Mtor	activates	pathway	0.60
TAU	inhibits	gene	0.60
SYN1	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
EIF4EBP1	activates	gene	0.60

Incoming (114)

Source	Relation	Type	Str
GFP	associated_with	gene	0.70
rapamycin	targets	drug	0.70
CTSD	activates	gene	0.60
PNPLA6	associated_with	gene	0.60
BAX	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
RPS6	associated_with	gene	0.60
EEA1	associated_with	gene	0.60
AKT	activates	gene	0.60
ATG	activates	gene	0.60
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
ABP	activates	gene	0.60
ATG16L1	activates	gene	0.60
BCL2	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CASP3	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
EGF	associated_with	gene	0.60
RNA	activates	gene	0.60
ATG7	associated_with	gene	0.60
ACTB	regulates	gene	0.60
ADAM10	regulates	gene	0.60
AIF1	regulates	gene	0.60
APOE	regulates	gene	0.60
APP	regulates	gene	0.60
BDNF	regulates	gene	0.60
BECN1	regulates	gene	0.60
CD68	regulates	gene	0.60
CREB1	regulates	gene	0.60
DLG4	regulates	gene	0.60
ABL1	regulates	gene	0.60
CTSD	regulates	gene	0.60
AMPK	activates	gene	0.60
ATG5	activates	gene	0.60
BECN1	activates	gene	0.60
CAMK2	activates	gene	0.60
DMPK	activates	gene	0.60
MTOR	activates	gene	0.60
P62	activates	gene	0.60
TUBULIN	activates	gene	0.60
JUN	activates	gene	0.60
LC3	activates	gene	0.60
LYSOSOME	associated_with	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
CTSD	associated_with	gene	0.60
CLN3	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DMSO in their description or question text

No additional research found