gene

GUSB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUSB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

45Outgoing

17Incoming

0Experiments

0Debates

Summary

GUSB is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Aging, Als, Cancer. Connected to 33 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GUSB
Chromosome	7q11.21
Protein Type	Hydrolase
Function	encodes a lysosomal hydrolase that catalyzes the hydrolysis of glucuronic acid residues from glycosaminoglycans (GAGs) within the lysosome.
Molecular Weight	73 kDa
Amino Acids	651 aa
Exons	11
Ensembl ID	ENSG00000135638
GeneCards	GUSB
Human Protein Atlas	GUSB
Human-Mouse	78% identical at the amino acid level
Human-Zebrafish	58% identical
Drosophila	Homolog with 35% identity
Yeast	Homologs in Saccharomyces cerevisiae (SGL1 and SGL2)
Heparan sulfate	Component of cell surfaces and extracellular matrix
Associated Diseases	Aging, Als, Cancer, Diabetes, Inflammation, Ms
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AMPK, CTSB, CTSD, EIF4EBP1, GFP
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

gusb

gene · 1511 words

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Pathway Diagram

graph TD
    GUSB["GUSB"]
    Diabetes{"Diabetes"}
    GUSB -->|"associated with"| Diabetes
    Als{"Als"}
    GUSB -->|"associated with"| Als
    Aging{"Aging"}
    GUSB -->|"associated with"| Aging
    Ms{"Ms"}
    GUSB -->|"associated with"| Ms
    Cancer{"Cancer"}
    GUSB -->|"associated with"| Cancer
    Inflammation{"Inflammation"}
    GUSB -->|"associated with"| Inflammation
    Complement(["Complement"])
    GUSB -->|"associated with"| Complement
    FGF21["FGF21"]
    GUSB -->|"associated with"| FGF21
    ALDH1A1["ALDH1A1"]
    GUSB -->|"therapeutic target"| ALDH1A1
    LPL["LPL"]
    GUSB -->|"therapeutic target"| LPL
    HMOX1["HMOX1"]
    GUSB -->|"associated with"| HMOX1
    CTSD["CTSD"]
    GUSB -->|"associated with"| CTSD
    FGF21 -->|"associated with"| GUSB
    HMOX1 -->|"associated with"| GUSB
    ALDH1A1 -->|"therapeutic target"| GUSB
    CTSD -->|"associated with"| GUSB
    LPL -->|"therapeutic target"| GUSB
    HDAC6["HDAC6"]
    HDAC6 -->|"associated with"| GUSB
    TP53["TP53"]
    TP53 -->|"associated with"| GUSB
    CCT2["CCT2"]
    CCT2 -->|"associated with"| GUSB
    style GUSB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (45)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	causes	disease	0.65
Aging	causes	disease	0.65
Diabetes	causes	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
LRP2	activates	gene	0.60
MCOLN1	activates	gene	0.60
SOX9	activates	gene	0.60
SQSTM1	activates	gene	0.60
TFEB	activates	gene	0.60
ULK1	activates	gene	0.60
VIM	activates	gene	0.60
Complement	associated_with	pathway	0.60
INFLAMMATION	associated_with	gene	0.60
NR1I2	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
Sphingolipid	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
ACE2	associated_with	gene	0.60
LDL	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MTORC1	activates	gene	0.60
PIKFYVE	activates	gene	0.60
PRKAA	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
FGF21	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
LPL	therapeutic_target	gene	0.60
HMOX1	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
TNF	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
HEXB	activates	gene	0.60
LC3	activates	gene	0.60
LGALS3	activates	gene	0.60

Incoming (17)

Source	Relation	Type	Str
FGF21	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
CTSD	associated_with	gene	0.60
LPL	therapeutic_target	gene	0.60
HDAC6	associated_with	gene	0.60
TP53	associated_with	gene	0.60
CCT2	associated_with	gene	0.60
ACTB	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
AMPK	activates	gene	0.60
GFP	activates	gene	0.60
rapamycin	targets	drug	0.60
LPL	associated_with	gene	0.60
ALDH1A1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GUSB in their description or question text

No additional research found