gene

ESR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

872Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ESR1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with ALS, Aging, Als. Connected to 361 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ESR1
Full Name	Estrogen Receptor Alpha
Chromosome	6q25.1
Protein Type	Gene
Function	Estrogen Receptor Alpha functions through multiple mechanisms:
Primary Expression	brain regions involved in cognition, mood, and neuroprotection, including the hippocampus, [cortex](/brain-regions/corte
Pathways	PI3K, MAPK
UniProt ID	P03372
NCBI Gene ID	2099
Ensembl ID	ENSG00000091831
GeneCards	ESR1
Human Protein Atlas	ESR1
Associated Diseases	Aging, Als, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compounds	Bisphenol F, Chrysotoxine, DEP, rapamycin
Interactions	A2M, ACTB, AKT, AKT1, ALS, AMPK
SciDEX Hypotheses	CX3CR1-Negative Trem2-High Microglial Subset Media
KG Connections	872 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ESR1 — AlphaFold P03372 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ESR1 — Estrogen Receptor Alpha

gene · 738 words

→

Pathway Diagram

flowchart TD
    ESR1["ESR1
(Estrogen Receptor alpha)"]
    
    %% Neurodegeneration pathways
    ESR1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ESR1 -->|"associated_with"| PD["Parkinson's Disease"]
    ESR1 -->|"associated_with"| MS["Multiple Sclerosis"]
    ESR1 -->|"activates"| ALS["Amyotrophic Lateral
Sclerosis"]
    
    %% Key protein interactions
    ESR1 -->|"associated_with"| APP["APP
(Amyloid Precursor
Protein)"]
    ESR1 -->|"associated_with"| PSEN1["PSEN1
(Presenilin 1)"]
    ESR1 -->|"associated_with"| MAP1LC3B["MAP1LC3B
(Autophagy Marker)"]
    ESR1 -->|"associated_with"| UVRAG["UVRAG
(Autophagy Regulator)"]
    
    %% Cellular pathways
    ESR1 -->|"activates"| ImmuneResp["Immune Response
Pathway"]
    ESR1 -->|"activates"| ERStress["ER Stress
Pathway"]
    
    %% Related receptors
    ESR1 -->|"expressed_in"| ESR2["ESR2
(Estrogen Receptor beta)"]
    ESR1 -->|"expressed_in"| TNF["TNF
(Tumor Necrosis Factor)"]
    
    %% Therapeutic implications
    ESR1 -->|"therapeutic_target"| ALSTherapy["ALS Therapy"]
    ESR1 -->|"therapeutic_target"| MSTherapy["MS Therapy"]
    
    %% Vascular connections
    ESR1 -->|"regulates"| Cardiovascular["Cardiovascular
Function"]
    ESR1 -->|"associated_with"| Ischemia["Cerebral Ischemia"]
    
    %% Styling
    style ESR1 fill:#006494
    style ImmuneResp fill:#1b5e20
    style ALSTherapy fill:#1b5e20
    style MSTherapy fill:#1b5e20
    style Cardiovascular fill:#1b5e20
    style Neurodegeneration fill:#ef5350
    style PD fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style ERStress fill:#ef5350
    style Ischemia fill:#ef5350
    style APP fill:#4a1a6b
    style PSEN1 fill:#4a1a6b
    style MAP1LC3B fill:#4a1a6b
    style UVRAG fill:#4a1a6b
    style ESR2 fill:#4a1a6b
    style TNF fill:#4a1a6b

Outgoing (501)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.95
Breast Cancer	implicated_in	disease	0.90
GENES	therapeutic_target	gene	0.90
Als	therapeutic_target	disease	0.85
luminal epithelial cell fate	promotes	process	0.85
Triple-Negative Breast Cancer	biomarker_for	disease	0.85
Cancer	treats	disease	0.85
Breast Cancer	treats	disease	0.85
Luminal Epithelial Cells	expressed_in	cell_type	0.85
ASC1	activates	protein	0.85
MAPK signaling	participates_in	pathway	0.80
Hormone-Dependent Cancer	involved_in	phenotype	0.80
AKT	therapeutic_target	gene	0.80
CANCER	therapeutic_target	gene	0.80
CANCER	treats	gene	0.80
Cognitive Function	regulates	phenotype	0.78
Tumor	therapeutic_target	disease	0.75
ALS	activates	disease	0.75
Cancer	interacts_with	disease	0.75
Als	treats	disease	0.75
Als	activates	disease	0.75
Autophagy	regulates	process	0.75
Inflammation	therapeutic_target	disease	0.75
Lipid Metabolism	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Mtor	treats	pathway	0.70
neural stem cells	regulates	cell_type	0.70
Hypothalamic-Pituitary-Adrenal Axis	modulates	pathway	0.70
HSP90AA1	targets	gene	0.70
AKT	treats	gene	0.70
SRC	therapeutic_target	gene	0.70
MTOR	treats	gene	0.70
HSP90AA1	associated_with	gene	0.70
GENES	interacts_with	gene	0.70
Carcinoma	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Als	regulates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Neuropathy	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65

Incoming (371)

Source	Relation	Type	Str
TP53	therapeutic_target	gene	1.00
Hippo pathway	interacts_with	pathway	0.90
OP	modulates	compound	0.90
NP	modulates	compound	0.90
DEP	binds	compound	0.90
ASC1	interacts_with	protein	0.90
EGFR	therapeutic_target	gene	0.90
UFM1	regulates	protein	0.88
Bisphenol F	binds	compound	0.85
Steroid Hormones	regulates	compound	0.85
LATS1	interacts_with	protein	0.85
LATS2	interacts_with	protein	0.85
PRKCD	associated_with	gene	0.80
Chrysotoxine	targets	compound	0.80
EP300	interacts_with	protein	0.80
SRC1	interacts_with	protein	0.80
ASC1	therapeutic_target	protein	0.80
DCAF1	mediates	gene	0.80
AKT1	therapeutic_target	gene	0.80
PI3K	therapeutic_target	gene	0.80
TNF	therapeutic_target	gene	0.80
PPARGC1A	interacts_with	gene	0.75
AKT1	interacts_with	gene	0.70
PI3K	treats	gene	0.70
STAT3	therapeutic_target	gene	0.70
PPARG	therapeutic_target	gene	0.70
IL6	therapeutic_target	gene	0.70
HSP90AA1	therapeutic_target	gene	0.70
JUN	therapeutic_target	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
GATA2	therapeutic_target	gene	0.70
FYCO1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
JUN	activates	gene	0.60
POMC	expressed_in	gene	0.60
PIK3C3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
ESR2	expressed_in	gene	0.60
GLA	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
HDAC6	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CX3CR1-Negative Trem2-High Microglial Subset Mediates Female	0.570	neuroinflammation	How do regional, age, and sex-dependent

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity