gene

FYCO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FYCO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

170Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for FYCO1 — FYVE and Coiled-Coil Domain Containing 1

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🧬 Gene Info

Gene Symbol	FYCO1
Full Name	FYVE and Coiled-Coil Domain Containing 1
Chromosome	3p21.2
Function	FYCO1 encodes a autophagy adapter protein that links autophagosomes to the microtubule-based transport machinery.
Primary Expression	the lens, and mutations cause congenital cataract, often accompanying spastic paraplegia in SPG59
Pathways	mTOR, mtor
UniProt ID	Q9BQR1
NCBI Gene ID	79443
Ensembl ID	ENSG00000164120
OMIM	607781
GeneCards	FYCO1
Human Protein Atlas	FYCO1
FYVE domain	binds to phosphatidylinositol 3-phosphate (PI3P) on autophagosomal membranes
Coiled-coil domains	mediate protein-protein interactions
LC3-interacting region (LIR)	binds LC3/GABARAP proteins
Associated Diseases	Cancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AMYLOID, AND, APOPTOSIS, AR, ATG
KG Connections	170 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FYCO1 — AlphaFold Q9BQR1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FYCO1 — FYVE and Coiled-Coil Domain Containing 1

gene · 583 words

→

FYCO1 Protein — FYVE and Coiled-Coil Domain Containing 1

protein · 802 words

→

Pathway Diagram

graph TD
    FYCO1["FYCO1"] -->|"associated"| Cancer["Cancer"]
    FYCO1["FYCO1"] -->|"associated"| Neurodegeneration["Neurodegeneration"]
    FYCO1["FYCO1"] -->|"associated"| Cardiovascular["Cardiovascular"]
    FYCO1["FYCO1"] -->|"associated"| Ischemia["Ischemia"]
    FYCO1["FYCO1"] -->|"associated"| Parkinson["Parkinson"]
    FYCO1["FYCO1"] -->|"associated"| Ms["Ms"]
    ULK1["ULK1"] -->|"associated"| FYCO1["FYCO1"]
    BCL2["BCL2"] -->|"associated"| FYCO1["FYCO1"]
    RAB9A["RAB9A"] -->|"associated"| FYCO1["FYCO1"]
    BCL2L1["BCL2L1"] -->|"associated"| FYCO1["FYCO1"]
    style FYCO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (95)

Target	Relation	Type	Str
Als	activates	disease	0.65
Ischemia	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
DR5	activates	gene	0.60
TRAIL	activates	gene	0.60
CASP8	activates	gene	0.60
TNF	activates	gene	0.60
GABARAP	activates	entity	0.60
GLA	activates	entity	0.60
HDAC6	activates	entity	0.60
LAMP2	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MTOR	activates	entity	0.60
PIK3C3	activates	entity	0.60
PSEN1	activates	entity	0.60
PSEN2	activates	entity	0.60
RAB9A	activates	entity	0.60
SOX9	activates	entity	0.60
TFEB	activates	entity	0.60
ULK1	activates	entity	0.60
UVRAG	activates	entity	0.60
VDAC2	activates	entity	0.60
WDR45	activates	entity	0.60
Rb	associated_with	protein	0.60
Autophagy	associated_with	pathway	0.60
PRESENILIN	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
LC3B	associated_with	gene	0.60
ATP6AP2	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
AMPK	associated_with	gene	0.60
Apoptosis	activates	pathway	0.60
AND	associated_with	gene	0.60
GABA	associated_with	gene	0.60
ATG	associated_with	gene	0.60
GABA	activates	gene	0.60
RAS	activates	gene	0.60

Incoming (75)

Source	Relation	Type	Str
ATG	activates	gene	0.60
ATP6AP2	activates	gene	0.60
CYP19A1	activates	gene	0.60
rapamycin	targets	drug	0.60
AMBRA1	activates	entity	0.60
APP	activates	entity	0.60
BCL2L1	activates	entity	0.60
BECN1	activates	entity	0.60
CTSD	activates	entity	0.60
ESR1	activates	entity	0.60
ESR2	activates	entity	0.60
AR	activates	gene	0.60
BCL2	activates	gene	0.60
AMPK	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
ATG	associated_with	gene	0.60
GABA	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
MICROTUBULES	activates	gene	0.60
PRESENILIN	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
RAB7A	interacts_with	gene	0.60
TNFSF10	activates	gene	0.60
TNFRSF1A	interacts_with	gene	0.60
APP	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
SPG21	interacts_with	gene	0.60
ESR1	associated_with	gene	0.60
RAB7	activates	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FYCO1 in their description or question text

No additional research found