Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HDC |
| Key Genes/Proteins | Actin, ADCY9, ADRA1D, AND, AUTOPHAGY, CALM2 |
| Related Pathways | Autophagy, Cell Cycle |
Knowledge base pages for this entity
graph TD
HDC["HDC"]
HDC -->|"regulates"| SOX9["SOX9"]
HDC -->|"regulates"| MERTK["MERTK"]
HDC -->|"regulates"| IRF1["IRF1"]
HDC -->|"regulates"| Autophagy["Autophagy"]
HDC -->|"regulates"| Cell_Cycle["Cell Cycle"]
HDC -->|"regulates"| Immune_Response["Immune Response"]
HDC -->|"regulates"| Mtor["Mtor"]
HDC -->|"regulates"| TSC22D3["TSC22D3"]
HRH2["HRH2"] -->|"upregulates"| HDC
ADRA1D["ADRA1D"] -->|"regulates"| HDC
IL6R["IL6R"] -->|"regulates"| HDC
ADCY9["ADCY9"] -->|"regulates"| HDC
PPP5C["PPP5C"] -->|"regulates"| HDC
NPY1R["NPY1R"] -->|"regulates"| HDC
DUSP1["DUSP1"] -->|"regulates"| HDC
VPS37B["VPS37B"] -->|"regulates"| HDC| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | biomarker_for | disease | 0.85 |
| Histamine metabolism | involved_in | pathway | 0.80 |
| IRF1 | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| SOX9 | regulates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| MERTK | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| ADRA1D | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| Actin | regulates | protein | 0.60 |
| SNAP25 | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADRA1D | regulates | gene | 0.60 |
| IL6R | regulates | gene | 0.60 |
| ADCY9 | regulates | gene | 0.60 |
| PPP5C | regulates | gene | 0.60 |
| NPY1R | regulates | gene | 0.60 |
| DUSP1 | regulates | gene | 0.60 |
| VPS37B | regulates | gene | 0.60 |
| LITAF | regulates | gene | 0.60 |
| TSC22D3 | regulates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| SESN1 | regulates | gene | 0.60 |
| PDK4 | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MYH2 | regulates | gene | 0.60 |
| CDKN1A | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| NDRG2 | regulates | gene | 0.60 |
| CALM2 | regulates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| CCND1 | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| SOX2 | regulates | gene | 0.60 |
| CD40LG | biomarker_for | gene | 0.60 |
| CX3CR1 | biomarker_for | gene | 0.60 |
| FUCA1 | biomarker_for | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| SOX9 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity