gene

acvr1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about acvr1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

0Analyses

41Outgoing

18Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ACVR1
Aliases	Activin A Receptor Type 1 (ALK2)
Chromosome	2q24.1
Protein Type	Serine/Threonine Kinase
Function	is a transmembrane serine/threonine kinase receptor that plays critical roles in development, tissue homeostasis, and disease pathogenesis.
Molecular Weight	56 kDa
Amino Acids	509 aa
Exons	11
Pathways	inflammation
GeneCards	ACVR1
Human Protein Atlas	ACVR1
Associated Diseases	Fibrodysplasia Ossificans Progressiva, neurodegeneration
Interactions	SMAD
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ACVR1 Gene

gene · 2349 words

→

Pathway Diagram

graph TD
    ACVR1["ACVR1"]
    ACVR1 -->|"causes"| Fibrodysplasia_Ossificans_Prog["Fibrodysplasia Ossificans Progressiva"]
    ACVR1 -->|"activates"| NF__B["NF-kappaB"]
    ACVR1 -->|"interacts"| Aging["Aging"]
    ACVR1 -->|"interacts"| Als["Als"]
    ACVR1 -->|"interacts"| Cancer["Cancer"]
    ACVR1 -->|"interacts"| Lymphoma["Lymphoma"]
    ACVR1 -->|"interacts"| Tumor["Tumor"]
    ACVR1 -->|"activates"| Inflammation["Inflammation"]
    PIK3CA["PIK3CA"] -->|"interacts"| ACVR1
    RANKINGS["RANKINGS"] -->|"interacts"| ACVR1
    RAC1["RAC1"] -->|"interacts"| ACVR1
    MAPK1["MAPK1"] -->|"interacts"| ACVR1
    PI3K["PI3K"] -->|"interacts"| ACVR1
    CBL["CBL"] -->|"interacts"| ACVR1
    AKT["AKT"] -->|"interacts"| ACVR1
    RHOA["RHOA"] -->|"interacts"| ACVR1

Outgoing (41)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ACVR1	data_in	dataset_row	0.00
Fibrodysplasia Ossificans Progressiva	causes	disease	0.90
NF-κB	activates	pathway	0.80
Lymphoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
AKT	activates	gene	0.60
NLRP3	activates	gene	0.60
SOX9	activates	gene	0.60
MTOR	activates	gene	0.60
SIRT1	activates	gene	0.60
PI3K	activates	gene	0.60
Pi3K	interacts_with	pathway	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
AMPK	activates	gene	0.60
BMP	activates	gene	0.60
NF-KB	activates	gene	0.60
Inflammasome	activates	pathway	0.60
Mtor	activates	pathway	0.60
Nf-Kb	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
AND	activates	gene	0.60
Insulin Signaling	interacts_with	pathway	0.60
Akt	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
Stem Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
mTOR	activates	entity	0.50
SMAD	activates	protein	0.50
inflammation	activates	pathway	0.50
NF-κB	activates	concept	0.50
MACROPHAGES	activates	concept	0.50
STEM CELLS	activates	concept	0.50

Incoming (18)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ACVR1	data_in	dataset_row	0.00
genes-acvr1	describes	wiki_page	0.95
MTOR	activates	gene	0.60
NLRP3	activates	gene	0.60
PIK3CA	interacts_with	gene	0.60
RANKINGS	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
CBL	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
RHOA	interacts_with	gene	0.60
RAC1	interacts_with	gene	0.60
TRAF6	interacts_with	gene	0.60
TGFBR1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
RAF1	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
TRAF2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity