gene

UVRAG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UVRAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

350Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

UVRAG is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Cancer. Connected to 193 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UVRAG
Full Name	UV Radiation Resistance Associated Gene
Chromosome	11q13.4
Function	It functions as a positive regulator of autophagy through multiple mechanisms
Molecular Weight	89 kDa
Amino Acids	783 aa
Exons	20
Pathways	PI3K
UniProt ID	[Q9P2K6](https://www.uniprot.org/uniprot/Q9P2K6)
Ensembl ID	ENSG00000136531
GeneCards	UVRAG
Human Protein Atlas	UVRAG
Associated Diseases	ALS, Cancer, Cardiovascular, dementia, frontotemporal, Inflammation
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AKT, AMBRA1, AMPK, AMYLOID, AND
KG Connections	350 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UVRAG Gene

gene · 645 words

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Pathway Diagram

flowchart TD
    UVRAG["UVRAG
UV Radiation Resistance
Associated Gene"]
    
    PIK3C3["PIK3C3
Class III PI3K"]
    ATG14["ATG14
Autophagy Protein"]
    MTOR["MTOR
Mechanistic Target
of Rapamycin"]
    
    Autophagy["Autophagy
Pathway"]
    UPS["Ubiquitin-Proteasome
System"]
    Proteasome["Proteasome
Pathway"]
    
    APP["APP
Amyloid Precursor
Protein"]
    H2AX["H2AX
DNA Damage
Response"]
    RAC1["RAC1
Small GTPase"]
    
    Neurodegeneration["Neurodegeneration
Disease Process"]
    Parkinsons["Parkinson's
Disease"]
    ALS["ALS
Amyotrophic Lateral
Sclerosis"]
    MS["Multiple
Sclerosis"]
    
    Aging["Cellular
Aging"]
    DNADamage["DNA Damage
Accumulation"]
    
    UVRAG -->|"forms complex"| PIK3C3
    UVRAG -->|"regulates"| ATG14
    UVRAG -->|"regulates"| Autophagy
    UVRAG -->|"regulates"| UPS
    UVRAG -->|"regulates"| Proteasome
    
    PIK3C3 -->|"activates"| Autophagy
    ATG14 -->|"promotes"| Autophagy
    MTOR -->|"inhibits"| Autophagy
    UVRAG -->|"associated with"| MTOR
    
    UVRAG -->|"regulates"| H2AX
    H2AX -->|"indicates"| DNADamage
    UVRAG -->|"associated with"| RAC1
    UVRAG -->|"associated with"| APP
    
    Autophagy -->|"clears"| APP
    UPS -->|"degrades"| APP
    
    UVRAG -->|"regulates"| Neurodegeneration
    UVRAG -->|"regulates"| ALS
    UVRAG -->|"associated with"| Parkinsons
    UVRAG -->|"associated with"| MS
    UVRAG -->|"regulates"| Aging
    
    DNADamage -->|"contributes to"| Aging
    Aging -->|"promotes"| Neurodegeneration
    
    style UVRAG fill:#006494
    style Autophagy fill:#1b5e20
    style UPS fill:#1b5e20
    style Proteasome fill:#1b5e20
    style PIK3C3 fill:#4a1a6b
    style ATG14 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style Neurodegeneration fill:#ef5350
    style Parkinsons fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Aging fill:#5d4400
    style DNADamage fill:#ef5350

Outgoing (203)

Target	Relation	Type	Str
Autophagy	interacts_with	pathway	0.70
AUTOPHAGY	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
epigenetic regulation	participates_in	pathway	0.70
Autophagy	activates	pathway	0.70
Als	contributes_to	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
Infection	regulates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Ms	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Aging	regulates	disease	0.65
Als	interacts_with	disease	0.65
LC3	interacts_with	gene	0.60
STX17	regulates	gene	0.60
Pi3K	regulates	pathway	0.60
VESICLE TRAFFICKING	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
Apoptosis	activates	pathway	0.60
INFLAMMATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
Stem Cell	associated_with	cell_type	0.60
Caspase	regulates	protein	0.60
Actin	regulates	protein	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
APP	associated_with	gene	0.60
YTHDF2	activates	gene	0.60
MTOR	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60

Incoming (147)

Source	Relation	Type	Str
AR	activates	gene	0.70
BECN1	regulates	gene	0.70
CASP3	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
PIK3C3	regulates	gene	0.60
RUBCN	activates	gene	0.60
AMBRA1	activates	entity	0.60
APP	activates	entity	0.60
BCL2L1	activates	entity	0.60
CTSD	activates	entity	0.60
CASP3	activates	gene	0.60
CDC42	activates	gene	0.60
GAPDH	activates	gene	0.60
GJA1	activates	gene	0.60
BCL2	activates	gene	0.60
ATG	associated_with	gene	0.60
SMURF1	activates	gene	0.60
CSNK1A1	regulates	gene	0.60
RAS	associated_with	gene	0.60
ATG14L	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
ROS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ACTB	regulates	gene	0.60
AND	associated_with	gene	0.60
CDC42	regulates	gene	0.60
ATG14	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity