gene 1,635 words KG: SOX9
Contents

SOX9 Gene

🧬 Gene Info
Gene SymbolSOX9
Full NameSRY-Box Transcription Factor 9
Chromosome17q24.3
Protein FamilySOX family (Sry-related HMG box)
Protein TypeTranscription Factor
Functionencodes a high-mobility-group (HMG) box transcription factor essential for chondrogenesis, neural crest development, sex determination, and glial cell differentiation.
Subcellular LocalizationNucleus
Molecular Weight56 kDa
Amino Acids509 aa
Gene TypeProtein coding
PathwaysApoptosis, Autophagy, Cell Cycle, Epigenetic, Hedgehog
UniProt IDP48436
NCBI Gene ID6662
Ensembl IDENSG00000125398
OMIM608161
GeneCardsSOX9
Human Protein AtlasSOX9
Associated DiseasesCancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compoundsrapamycin
InteractionsACTB, Actin, ACVR1, AGING, AKT, AMPK
KG Connections364 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ACVR1 Gene
gene · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

ULK1 associated_with SOX9
BCL2 associated_with SOX9
RAB9A associated_with SOX9
BCL2L1 associated_with SOX9
GLA associated_with SOX9
GABARAP associated_with SOX9
PSEN2 associated_with SOX9
CTSD associated_with SOX9
FYCO1 associated_with SOX9
LAMP2 associated_with SOX9

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