concept

CYP19A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP19A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

160Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CYP19A1
Key Genes/Proteins	AMBRA1, AMPK, AMYLOID, Amyloid Beta, AND, APP
Related Diseases	Autism, autism spectrum disorder
Related Pathways	Amyloid, Autophagy, autophagy pathway

Pathway Diagram

graph TD
    CYP19A1["CYP19A1"]
    CYP19A1 -->|"involved_in"| Estradiol["Estradiol"]
    CYP19A1 -->|"regulates"| Sex_Differences_In_Autophagy["Sex Differences In Autophagy"]
    CYP19A1 -->|"expressed in"| Inflammation["Inflammation"]
    CYP19A1 -->|"expressed in"| STAR["STAR"]
    CYP19A1 -->|"expressed in"| IL_6["IL-6"]
    CYP19A1 -->|"expressed in"| Nf__b["Nf-Kappab"]
    CYP19A1 -->|"expressed in"| AND["AND"]
    CYP19A1 -->|"expressed in"| SIRT1["SIRT1"]
    TFEB["TFEB"] -->|"binds_to"| CYP19A1
    AMPK["AMPK"] -->|"expressed in"| CYP19A1
    CYP17A1["CYP17A1"] -->|"expressed in"| CYP19A1
    SIRT1 -->|"expressed in"| CYP19A1
    IL_1["IL-1"] -->|"expressed in"| CYP19A1
    STAR -->|"expressed in"| CYP19A1
    INFLAMMATION["INFLAMMATION"] -->|"expressed in"| CYP19A1
    INSULIN_RESISTANCE["INSULIN RESISTANCE"] -->|"expressed in"| CYP19A1

Outgoing (99)

Target	Relation	Type	Str
sex differences	drives	phenotype	0.75
Autism	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	expressed_in	disease	0.65
GABARAP	associated_with	gene	0.60
APP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
AND	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
GABA	associated_with	gene	0.60
ATG	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Amyloid	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
PSEN2	associated_with	gene	0.60
GLA	associated_with	gene	0.60
AND	expressed_in	gene	0.60
SIRT1	expressed_in	gene	0.60
TNF-Α	expressed_in	gene	0.60
CYP17A1	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
Insulin	expressed_in	protein	0.60
Cytokine	expressed_in	protein	0.60
Il-1	expressed_in	protein	0.60
ESR1	activates	gene	0.60
ESR2	activates	gene	0.60
FYCO1	activates	gene	0.60
GABA	activates	gene	0.60
GABARAP	activates	gene	0.60
GLA	activates	gene	0.60
HDAC6	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60

Incoming (61)

Source	Relation	Type	Str
TFEB	associated_with	protein	0.90
INFLAMMATION	expressed_in	gene	0.60
INSULIN RESISTANCE	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
CANCER	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
AMPK	expressed_in	gene	0.60
CYP17A1	expressed_in	gene	0.60
SIRT1	expressed_in	gene	0.60
STAR	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
AND	associated_with	gene	0.60
RNA	associated_with	gene	0.60
GABA	associated_with	gene	0.60
ATG	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
APP	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
IL-6	expressed_in	gene	0.60
TNF-Α	expressed_in	gene	0.60
AMBRA1	activates	gene	0.60
AMPK	activates	gene	0.60
APP	activates	gene	0.60
AR	activates	gene	0.60
ATG	activates	gene	0.60
ATP6AP2	activates	gene	0.60
BCL2	activates	gene	0.60
BCL2L1	activates	gene	0.60
BECN1	activates	gene	0.60
CTSD	activates	gene	0.60
rapamycin	targets	drug	0.60
CYP17A1	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYP19A1 in their description or question text

No additional research found