gene

GLA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

281Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GLA is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, contributes to. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 156 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GLA
Aliases	Page for GLA Gene
Protein Type	Hydrolase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	50 kDa
Pathways	autophagy pathway, epigenetic regulation, oxidative stress response
Ensembl ID	ENSG00000102393
GeneCards	GLA
Human Protein Atlas	GLA
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Cardiovascular
Known Drugs/Compounds	rapamycin
Interactions	AR, ATG, ATG10, ATG12, ATP6AP2, CALCINEURIN
KG Connections	281 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GLA["GLA
(Alpha-galactosidase A)"]
    
    %% Autophagy pathway
    GLA -->|"activates"| ATG12["ATG12
(Autophagy protein)"]
    ATG12 -->|"promotes"| Autophagy["Autophagy
(Cellular clearance)"]
    GLA -->|"associated_with"| BECN1["BECN1
(Beclin-1)"]
    BECN1 -->|"regulates"| Autophagy
    
    %% Calcium signaling and cellular stress
    GLA -->|"activates"| CALCINEURIN["CALCINEURIN
(Protein phosphatase)"]
    CALCINEURIN -->|"regulates"| Calcium_Signaling["Calcium
Signaling"]
    
    %% Protein quality control
    GLA -->|"associated_with"| STUB1["STUB1
(CHIP ubiquitin ligase)"]
    GLA -->|"associated_with"| HSPB8["HSPB8
(Heat shock protein)"]
    STUB1 -->|"promotes"| Protein_Degradation["Protein
Degradation"]
    HSPB8 -->|"maintains"| Protein_Folding["Protein
Folding"]
    
    %% RNA processing and neurodegeneration
    GLA -->|"associated_with"| TARDBP["TARDBP
(TDP-43)"]
    TARDBP -->|"dysfunction"| RNA_Processing["RNA Processing
Defects"]
    
    %% Metabolic regulation
    GLA -->|"associated_with"| PPARGC1A["PPARGC1A
(PGC-1alpha)"]
    PPARGC1A -->|"regulates"| Mitochondrial_Function["Mitochondrial
Function"]
    
    %% Neurodegenerative diseases
    GLA -->|"activates"| Neurodegeneration["Neurodegeneration"]
    Neurodegeneration -->|"manifests_as"| ALS["Amyotrophic
Lateral Sclerosis"]
    Neurodegeneration -->|"manifests_as"| Parkinsons["Parkinson's
Disease"]
    Neurodegeneration -->|"manifests_as"| Huntingtons["Huntington's
Disease"]
    Neurodegeneration -->|"manifests_as"| Ataxia["Ataxia"]
    
    %% Cellular dysfunction pathways
    Protein_Degradation -->|"failure_leads_to"| Neurodegeneration
    RNA_Processing -->|"impairment_causes"| Neurodegeneration
    Mitochondrial_Function -->|"dysfunction_promotes"| Neurodegeneration
    Calcium_Signaling -->|"dysregulation_contributes"| Neurodegeneration
    
    %% Styling
    style GLA fill:#006494
    style Autophagy fill:#1b5e20
    style Protein_Folding fill:#1b5e20
    style ATG12 fill:#4a1a6b
    style BECN1 fill:#4a1a6b
    style STUB1 fill:#4a1a6b
    style HSPB8 fill:#4a1a6b
    style PPARGC1A fill:#4a1a6b
    style CALCINEURIN fill:#4a1a6b
    style TARDBP fill:#ef5350
    style RNA_Processing fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style ALS fill:#5d4400
    style Parkinsons fill:#5d4400
    style Huntingtons fill:#5d4400
    style Ataxia fill:#5d4400

Outgoing (173)

Target	Relation	Type	Str
RNA	activates	gene	0.70
Parkinson's disease	activates	disease	0.70
autophagy pathway	participates_in	pathway	0.70
Ischemia	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
ALS	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Tumor	contributes_to	disease	0.65
Autism	contributes_to	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
Sod1	associated_with	pathway	0.60
BCL2L1	associated_with	gene	0.60
TDP-43	associated_with	gene	0.60
P62	associated_with	gene	0.60
Neural Progenitor	associated_with	cell_type	0.60
Rb	associated_with	protein	0.60
neurodegeneration	activates	disease	0.60
cerebellum	expressed_in	brain_region	0.60
Chaperone	associated_with	pathway	0.60
Amyloid	associated_with	pathway	0.60
GENES	activates	gene	0.60
RAS	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
SOD1	associated_with	gene	0.60
ATP6AP2	associated_with	gene	0.60
RAS	associated_with	gene	0.60
Sphingolipid	contributes_to	pathway	0.60
Lipid Metabolism	contributes_to	pathway	0.60
HUNTINGTON	associated_with	gene	0.60
CGAS-STING	expressed_in	gene	0.60
DNA	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
Innate Immunity	inhibits	pathway	0.60
Cgas-Sting	expressed_in	pathway	0.60

Incoming (108)

Source	Relation	Type	Str
AR	activates	gene	0.70
rapamycin	targets	drug	0.70
ATG	activates	gene	0.70
AND	expressed_in	gene	0.60
AND	associated_with	gene	0.60
RNA	associated_with	gene	0.60
GABA	associated_with	gene	0.60
CYP19A1	associated_with	gene	0.60
MAGI2	activates	gene	0.60
DNA	activates	gene	0.60
ULK1	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
VDAC2	associated_with	gene	0.60
ARSA	associated_with	gene	0.60
AMBRA1	activates	entity	0.60
APP	activates	entity	0.60
BCL2L1	activates	entity	0.60
CTSD	activates	entity	0.60
ESR1	activates	entity	0.60
ESR2	activates	entity	0.60
FYCO1	activates	entity	0.60
GABARAP	activates	entity	0.60
GALC	inhibits	gene	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
PPP3	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
MYELIN	contributes_to	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
DSDNA	inhibits	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
CYP19A1	activates	gene	0.60
GABA	activates	gene	0.60
TARDBP	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GLA in their description or question text

No additional research found

GLA