protein

VDAC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VDAC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

215Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for VDAC2 — Voltage-Dependent Anion Channel 2 Protein

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🔬 Protein Info

Gene Symbol	VDAC2
Full Name	Voltage-Dependent Anion Channel 2
Chromosome	10q22.2
Function	### Mitochondrial Metabolite Transport
Primary Expression	Ubiquitous, high in brain, heart, skeletal muscle
Molecular Weight	31.6 kDa
Amino Acids	294 aa
Pathways	Autophagy, autophagy pathway, epigenetic regulation, mitophagy, oxidative stress response
UniProt ID	P45880
NCBI Gene ID	7417
Ensembl ID	ENSG00000165637
OMIM	193245
GeneCards	VDAC2
Human Protein Atlas	VDAC2
Open state (low voltage)	Conducts anions (ATP4-, ADP3-, Pi) and small metabolites, enabling oxidative phosphorylation
Associated Diseases	Cancer, Cardiovascular, Inflammation, Ischemia, Ms, Neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AMYLOID, AND, APOPTOSIS, AR, ATF4
KG Connections	215 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VDAC2 — AlphaFold P45880 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VDAC2 — Voltage-Dependent Anion Channel 2

gene · 851 words

→

VDAC2 — Voltage-Dependent Anion Channel 2 Protein

protein · 1023 words

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Pathway Diagram

graph TD
    VDAC2["VDAC2"]
    VDAC2 -->|"inhibits"| IFN__["IFN-gamma"]
    VDAC2 -->|"inhibits"| IFN_gamma_mediated_tumor_destr["IFN-gamma-mediated tumor destruction"]
    VDAC2 -->|"inhibits"| Leukemia["Leukemia"]
    VDAC2 -->|"inhibits"| Autoimmune["Autoimmune"]
    VDAC2 -->|"inhibits"| Lymphoma["Lymphoma"]
    VDAC2 -->|"regulates"| Cancer["Cancer"]
    VDAC2 -->|"regulates"| Cardiovascular["Cardiovascular"]
    VDAC2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    VDAC2 -->|"activates"| Carcinoma["Carcinoma"]
    VDAC2 -->|"activates"| Tumor["Tumor"]
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| VDAC2
    BAX["BAX"] -->|"inhibits"| VDAC2
    BCL_2["BCL-2"] -->|"inhibits"| VDAC2
    MITOPHAGY["MITOPHAGY"] -->|"interacts"| VDAC2
    TMX2["TMX2"] -->|"interacts"| VDAC2

Outgoing (111)

Target	Relation	Type	Str
IFN-γ	inhibits	protein	0.90
Tumour Destruction	causes	process	0.90
Cancer	treats	disease	0.88
Inflammation	causes	process	0.85
Immune Evasion	inhibits	process	0.82
CD8+ T Cell	activates	cell_type	0.80
IFN-gamma-mediated tumor destruction	inhibits	phenotype	0.80
Als	activates	disease	0.65
Leukemia	inhibits	disease	0.65
Ischemia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Autoimmune	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Lymphoma	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ferroptosis	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Cancer	regulates	disease	0.65
ESR2	associated_with	gene	0.60
YTHDF2	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
Parkinson's disease	activates	disease	0.60
Fus	associated_with	protein	0.60
BCL2	associated_with	gene	0.60
PRKN	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
PIK3C3	associated_with	gene	0.60
Cathepsin	associated_with	protein	0.60
WDR45	associated_with	gene	0.60
Amyloid Beta	associated_with	protein	0.60
AMYLOID	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
BAX	inhibits	gene	0.60
TFEB	activates	gene	0.60
SOX9	associated_with	gene	0.60
AND	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
APP	associated_with	gene	0.60

Incoming (104)

Source	Relation	Type	Str
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
FYCO1	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
SOX9	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
ESR1	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
APP	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
BAX	inhibits	gene	0.60
TMX2	interacts_with	gene	0.60
ESR2	associated_with	gene	0.60
AMBRA1	activates	entity	0.60
APP	activates	entity	0.60
BCL2L1	activates	entity	0.60
BECN1	activates	entity	0.60
CTSD	activates	entity	0.60
ESR1	activates	entity	0.60
ESR2	activates	entity	0.60
FYCO1	activates	entity	0.60
GABARAP	activates	entity	0.60
GLA	activates	entity	0.60
HDAC6	activates	entity	0.60
LAMP2	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MTOR	activates	entity	0.60
PIK3C3	activates	entity	0.60
PSEN1	activates	entity	0.60
PSEN2	activates	entity	0.60
RAB9A	activates	entity	0.60
SOX9	activates	entity	0.60
TFEB	activates	entity	0.60
ULK1	activates	entity	0.60
UVRAG	activates	entity	0.60
NRF2	activates	gene	0.60
HMOX1	activates	gene	0.60
ULK1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VDAC2 in their description or question text

No additional research found