gene 968 words KG: LC3
Contents

MAP1LC3A Gene

🧬 Gene Info
Gene SymbolLC3
AliasesMicrotubule-Associated Protein 1 Light Chain 3
Protein TypeTranscription Factor
FunctionLC3 is essential for autophagosome formation and function
Molecular Weight17 kDa
PathwaysAkt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
GeneCardsLC3
Human Protein AtlasLC3
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin
Interactions6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1
KG Connections3246 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (75)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
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Related Analyses (17)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (21)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40

See Also (6)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABCG1 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

FOXO3 regulates LC3
autophagy_pathway regulates LC3
ACTB interacts_with LC3
P2RY12 activates LC3
APOA1 interacts_with LC3
ULK1 interacts_with LC3
EIF4EBP1 interacts_with LC3
LC3 inhibits MTOR
LC3 interacts_with ABCG1
LC3 activates SQSTM1

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