concept

COL1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COL1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

COL1A1 is a concept in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Als, Atherosclerosis, Cancer. Connected to 121 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	COL1A1
Key Genes/Proteins	ACTB, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS
Related Diseases	Als, Alzheimer, atherosclerosis, Atherosclerosis
Related Pathways	Akt, Apoptosis, Autophagy

Pathway Diagram

graph TD
    COL1A1["COL1A1"]
    COL1A1 -->|"expressed in"| Cancer["Cancer"]
    COL1A1 -->|"expressed in"| Tumor["Tumor"]
    COL1A1 -->|"inhibits"| Fibrosis["Fibrosis"]
    COL1A1 -->|"inhibits"| Als["Als"]
    COL1A1 -->|"expressed in"| Ms["Ms"]
    COL1A1 -->|"activates"| Inflammation["Inflammation"]
    COL1A1 -->|"target for"| Hepatitis["Hepatitis"]
    MIRNAS["MIRNAS"] -->|"expressed in"| COL1A1
    MICRORNAS["MICRORNAS"] -->|"expressed in"| COL1A1
    CANCER["CANCER"] -->|"expressed in"| COL1A1
    MCC["MCC"] -->|"expressed in"| COL1A1
    UBIQUITIN["UBIQUITIN"] -->|"interacts"| COL1A1
    FERROPTOSIS["FERROPTOSIS"] -->|"interacts"| COL1A1

Outgoing (123)

Target	Relation	Type	Str
endometrial remodeling	upregulates	process	0.80
Hepatocellular Carcinoma	associated_with	disease	0.75
Fibrosis	associated_with	disease	0.75
Carcinoma	associated_with	disease	0.75
FTH1	associated_with	gene	0.70
P62	associated_with	gene	0.70
PTGS2	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70
ROS	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
ATG	associated_with	gene	0.70
NCOA4	associated_with	gene	0.70
osteoporosis	associated_with	disease	0.70
atherosclerosis	associated_with	disease	0.70
Tumor	associated_with	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Fibrosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Als	activates	disease	0.65
Macular Degeneration	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ferroptosis	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Proteasome	activates	pathway	0.60
MMP9	therapeutic_target	gene	0.60
UBIQUITIN	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
ITGA5	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
MMP2	therapeutic_target	gene	0.60
Nf-Κb	therapeutic_target	pathway	0.60

Incoming (65)

Source	Relation	Type	Str
SQSTM1	associated_with	gene	0.70
extracellular vesicles	associated_with	gene	0.70
ELAVL1	associated_with	gene	0.70
GPX4	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
TNF	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
ATG	associated_with	gene	0.60
P53	associated_with	gene	0.60
TP53	associated_with	gene	0.60
FERROPTOSIS	interacts_with	gene	0.60
NCOA4	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
TGFB1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
MAF	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
SRC	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
IBSP	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
RAC2	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
MCC	expressed_in	gene	0.60
THBS2	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
BECN1	interacts_with	gene	0.60
GBM	associated_with	gene	0.60
AND	activates	gene	0.60
PSMA3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
KIF23	associated_with	gene	0.60
KIF11	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
CD8	associated_with	gene	0.60
FN1	associated_with	gene	0.60
BAX	inhibits	gene	0.60
ROS	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COL1A1 in their description or question text

No additional research found