gene 1,819 words KG: DEPTOR
Contents

DEPTOR

🧬 Gene Info
Gene SymbolDEPTOR
AliasesDEP domain-containing mTOR interacting protein
Chromosome8q24.3
Functionis an endogenous inhibitor of both mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2.
Primary Expressionneurons and glia, where it plays important roles in regulating autophagy, synaptic plasticity, and cellular stress responses
Molecular Weight46 kDa
Amino Acids409 aa
Exons11
PathwaysMTOR, mTOR, mTOR signaling
Ensembl IDENSG00000155792
GeneCardsDEPTOR
Human Protein AtlasDEPTOR
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsActin, AKT1, AKT1S1, AMBRA1, AMPK, AND
KG Connections308 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.85
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70

Related Analyses (4)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (14)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
AKT1 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ATF6 interacts_with DEPTOR
OPTN interacts_with DEPTOR
CASP3 interacts_with DEPTOR
AKT1 interacts_with DEPTOR
CALCOCO2 interacts_with DEPTOR
CGAS interacts_with DEPTOR
CFTR interacts_with DEPTOR
SQSTM1 interacts_with DEPTOR
RPS6KB1 interacts_with DEPTOR
GRB2 interacts_with DEPTOR

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