gene

SIRT5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

217Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SIRT5 - Sirtuin 5, mitochondrial sirtuin with desuccinylation, demalonylation, and deglutarylation activities

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🧬 Gene Info

Gene Symbol	SIRT5
Full Name	Sirtuin 5
Aliases	Page for SIRT5 Protein
Chromosome	6p23
Protein Family	Sirtuin family (class I)
Function	is a member of the sirtuin family of NAD⁺-dependent protein deacylases that is primarily localized to mitochondria.
Subcellular Localization	mitochondria. Unlike other sirtuins, SIRT5 possesses unique enzymatic activities including desuccinylation, demalonylati
Molecular Weight	34 kDa
Amino Acids	310 aa
Pathways	Glutamine Metabolism, Glycolysis, Mitophagy, Oxidative Stress, Unfolded Protein Response
UniProt ID	Q9NXE1
NCBI Gene ID	83737
Ensembl ID	ENSG00000124587
OMIM	604603
GeneCards	SIRT5
Human Protein Atlas	SIRT5
Associated Diseases	Als, Alzheimer, cancer
Known Drugs/Compounds	Mc3482, MC3482
Interactions	AGING, AKT2, ALZHEIMER, ALZHEIMER'S DISEASE, AND, App
KG Connections	217 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SIRT5 — AlphaFold Q9NXE1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SIRT5 - Sirtuin 5

gene · 1536 words

→

SIRT5 Protein - Mitochondrial Desuccinylase

protein · 1247 words

→

Pathway Diagram

graph TD
    SIRT5["SIRT5"]
    SIRT5 -->|"contributes to"| Cancer["Cancer"]
    SIRT5 -->|"activates"| Als["Als"]
    SIRT5 -->|"regulates"| Inflammation["Inflammation"]
    SIRT5 -->|"regulates"| Cardiac["Cardiac"]
    SIRT5 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    SIRT5 -->|"regulates"| Parkinson["Parkinson"]
    SIRT5 -->|"regulates"| Alzheimer["Alzheimer"]
    SIRT5 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    SIRT5 -->|"regulates"| Huntington["Huntington"]
    SIRT5 -->|"regulates"| Ms["Ms"]
    GABARAP["GABARAP"] -->|"activates"| SIRT5
    GABARAPL2["GABARAPL2"] -->|"activates"| SIRT5
    BNIP3["BNIP3"] -->|"activates"| SIRT5
    SIRT6["SIRT6"] -->|"expressed in"| SIRT5
    HDAC11["HDAC11"] -->|"regulates"| SIRT5
    HDAC2["HDAC2"] -->|"regulates"| SIRT5
    SIRT7["SIRT7"] -->|"expressed in"| SIRT5

Outgoing (140)

Target	Relation	Type	Str
Ammonia Detoxification	regulates	process	0.95
CPS1	regulates	enzyme	0.95
RAB7A	mediates	protein	0.90
Glutaminase	interacts_with	enzyme	0.90
Autophagic Flux	regulates	process	0.90
Autophagy	regulates	process	0.90
Ammonia Production	regulates	process	0.90
Glutamine Metabolism	regulates	pathway	0.90
Glutaminase	modulates	enzyme	0.90
Mitophagy	modulates	process	0.85
Autophagy	modulates	process	0.85
GLS	modulates	gene	0.85
mitophagy	inhibits	process	0.85
autophagy	inhibits	process	0.85
GLUTAMINASE	interacts_with	enzyme	0.85
PINK1	regulates	entity	0.80
LC3	regulates	entity	0.80
RAB7A	associated_with	protein	0.80
Als	activates	disease	0.75
Senescence	activates	disease	0.75
Inflammation	regulates	disease	0.75
AUTOPHAGY	activates	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Breast Cancer	contributes_to	disease	0.65
Autoimmune	expressed_in	disease	0.65
Aging	regulates	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Ms	regulates	disease	0.65
Als	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
Huntington	regulates	disease	0.65
Cancer	contributes_to	disease	0.65
Cancer	inhibits	disease	0.65
Cardiac	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Aging	activates	disease	0.65
Als	associated_with	disease	0.65
PARK2	activates	gene	0.60
PINK1	activates	gene	0.60
Fus	activates	protein	0.60
BNIP3	activates	gene	0.60

Incoming (77)

Source	Relation	Type	Str
Mc3482	inhibits	drug	0.90
MC3482	inhibits	drug	0.85
SIRT4	expressed_in	gene	0.80
SIRT3	expressed_in	gene	0.80
SIRT2	expressed_in	gene	0.80
SIRT1	expressed_in	gene	0.80
SIRT6	expressed_in	gene	0.70
SIRT7	expressed_in	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
HDAC2	regulates	gene	0.60
CANCER	expressed_in	entity	0.60
AKT2	targets	gene	0.60
HDAC11	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
GENES	regulates	gene	0.60
AND	activates	gene	0.60
AGING	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
ROS	activates	gene	0.60
BNIP3	regulates	gene	0.60
GABARAP	regulates	gene	0.60
GABARAPL2	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PARK2	regulates	gene	0.60
BDNF	regulates	gene	0.60
HDAC3	regulates	gene	0.60
RAB7A	inhibits	gene	0.60
CANCER	contributes_to	gene	0.60
NAD	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
HUNTINGTON'S DISEASE	regulates	gene	0.60
NEURON	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
GABARAP	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SIRT5 in their description or question text

No additional research found