gene 738 words KG: BNIP3L
Contents

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

🧬 Gene Info
Gene SymbolBNIP3L
Full NameBCL2 Interacting Protein 3 Like (NIX)
Chromosome8p21.2
FunctionMitochondrial recruitment: Being anchored to the mitochondrial outer membrane, BNIP3L clusters at sites of autophagosome initiation
Primary ExpressionCerebral cortex, Mitochondria, Substantia nigra
PathwaysAdaptive Immunity, Apoptosis, Autophagy, Epigenetic, Immune Response
UniProt IDO60238
NCBI Gene ID665
OMIM603588
GeneCardsBNIP3L
Human Protein AtlasBNIP3L
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
InteractionsABCD3, ADORA2A, AGING, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections1003 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
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Related Analyses (14)

Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (11)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ADORA2A Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: therapeutic_target
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with BNIP3L
OPTN interacts_with BNIP3L
DNM1L interacts_with BNIP3L
CANX interacts_with BNIP3L
LGALS3 interacts_with BNIP3L
CALCOCO2 interacts_with BNIP3L
G3BP1 interacts_with BNIP3L
PEX3 interacts_with BNIP3L
SQSTM1 interacts_with BNIP3L
BCL2 interacts_with BNIP3L

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