concept

SRT2104

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRT2104: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

21Outgoing

1Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SRT2104
Key Genes/Proteins	PINK1, PRKN, SIRT1, TP53
Related Diseases	Age-Related Degeneration In Auditory System, Age-related hearing loss, Age-Related Neurodegeneration, Cellular Senescence, senescence

Pathway Diagram

graph TD
    SRT2104[SRT2104]
    SRT2104 -->|activates| SIRT1[SIRT1]
    SRT2104 -->|suppresses| Cellular_Senescence[Cellular Senescence]
    SRT2104 -->|upregulates| PINK1[PINK1]
    SRT2104 -->|upregulates| PRKN[PRKN]
    SRT2104 -->|downregulates| TP53[TP53]
    SRT2104 -.protects against.-> Age_Related_Neurodegeneration[Age-Related Neurodegeneration]
    SRT2104 -->|upregulates| Mitochondrial_Membrane_Potenti[Mitochondrial Membrane Potential]
    SRT2104 -.protects against.-> senescence[senescence]
    SRT2104 -->|treats| Age_Related_Degeneration_In_Au[Age-Related Degeneration In Auditory System]
    SIRT1 -->|interacts| SRT2104

Outgoing (21)

Target	Relation	Type	Str
SIRT1	activates	protein	0.95
SIRT1	activates	protein	0.95
Cellular Senescence	suppresses	phenotype	0.93
TP53	downregulates	gene	0.92
PRKN	upregulates	gene	0.92
PINK1	upregulates	gene	0.92
Age-Related Neurodegeneration	protects_against	disease	0.90
Mitochondrial Membrane Potential	upregulates	biomarker	0.90
senescence	protects_against	phenotype	0.90
Age-Related Degeneration In Auditory System	treats	disease	0.88
auditory cells	expressed_in	cell_type	0.85
Age-related hearing loss	treats	disease	0.80
mitochondrial membrane potential	associated_with	phenotype	0.80
TP53	downregulates	protein	0.80
PINK1	upregulates	protein	0.80
Cdkn1A	downregulates	protein	0.80
auditory hair cells	protects_against	cell_type	0.80
BNIP3	upregulates	protein	0.80
PRKN	upregulates	protein	0.80
Age-related hearing loss	treats	disease	0.75
age-related hearing loss	protects_against	disease	0.75

Incoming (1)

Source	Relation	Type	Str
SIRT1	interacts_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity