gene

TIGAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIGAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

0Experiments

0Debates

Summary

TIGAR encodes a fructose-2,6-bisphosphatase that redirects glucose flux between glycolysis and the pentose phosphate pathway, playing neuroprotective roles in Alzheimer's, Parkinson's, and ALS through metabolic regulation and redox homeostasis

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🧬 Gene Info

Gene Symbol	TIGAR
Full Name	TP53-Induced Glycolysis and Apoptosis Regulator
Chromosome	12p13.1
Protein Type	Enzyme
Function	is a gene encoding a bifunctional enzyme with fructose-2,6-bisphosphatase activity.
Exons	6
Pathways	Apoptosis, Autophagy, Chaperone, Glycolysis, Mitophagy
UniProt ID	[Q9Y2H7](https://www.uniprot.org/uniprot/Q9Y2H7)
Ensembl ID	ENSG00000148231
OMIM	610335
GeneCards	TIGAR
Human Protein Atlas	TIGAR
Hippocampus	High expression in CA1 pyramidal neurons, dentate granule cells — regions critical for memory that are affected early in AD
Cerebral cortex	Layer 5 pyramidal neurons show prominent TIGAR expression
Substantia nigra	Dopaminergic neurons express TIGAR, where it may modulate vulnerability to PD pathology
Associated Diseases	AD, Als, AMI, ARM, cancer
Interactions	ATM, ATR, CANCER, DNA, ERK, GAIN
KG Connections	111 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

gene · 2588 words

→

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

protein · 1054 words

→

Pathway Diagram

graph TD
    TIGAR["TIGAR"]
    Cancer{"Cancer"}
    TIGAR -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    TIGAR -->|"therapeutic target"| Carcinoma
    Ms{"Ms"}
    TIGAR -->|"activates"| Ms
    Als{"Als"}
    TIGAR -->|"activates"| Als
    TIGAR -->|"regulates"| Als
    Ischemia{"Ischemia"}
    TIGAR -->|"regulates"| Ischemia
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    TIGAR -->|"regulates"| Traumatic_Brain_Injury
    Tumor{"Tumor"}
    TIGAR -->|"regulates"| Tumor
    TIGAR -->|"regulates"| Ms
    TIGAR -->|"activates"| Ischemia
    TIGAR -->|"activates"| Traumatic_Brain_Injury
    TIGAR -->|"activates"| Tumor
    TKT["TKT"]
    TKT -->|"therapeutic target"| TIGAR
    HIF1["HIF1"]
    HIF1 -->|"regulates"| TIGAR
    BNIP3["BNIP3"]
    BNIP3 -->|"regulates"| TIGAR
    IDH2["IDH2"]
    IDH2 -->|"therapeutic target"| TIGAR
    FOXO3["FOXO3"]
    FOXO3 -->|"regulates"| TIGAR
    LC3["LC3"]
    LC3 -->|"regulates"| TIGAR
    NRF2["NRF2"]
    NRF2 -->|"regulates"| TIGAR
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| TIGAR
    P62["P62"]
    P62 -->|"regulates"| TIGAR
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"regulates"| TIGAR
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| TIGAR
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"regulates"| TIGAR
    style TIGAR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (80)

Target	Relation	Type	Str
IDH2	associated_with	entity	0.85
Poor Prognosis	associated_with	phenotype	0.80
Tumor	activates	disease	0.75
Ischemia	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Ischemia	regulates	disease	0.65
ALS	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
ALS	regulates	disease	0.65
BNIP3	regulates	gene	0.60
LC3	regulates	gene	0.60
NRF2	regulates	gene	0.60
FOXO3	regulates	gene	0.60
TAK1	activates	gene	0.60
TP53	regulates	gene	0.60
TKT	expressed_in	entity	0.60
TKT	regulates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
GAIN	activates	gene	0.60
TKT	therapeutic_target	gene	0.60
AUTOPHAGY	regulates	gene	0.60
HIF	activates	gene	0.60
AND	regulates	gene	0.60
ALS	associated_with	disease	0.60
IDH2	therapeutic_target	gene	0.60
Chaperone	regulates	pathway	0.60
APOPTOSIS	regulates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
Apoptosis	regulates	pathway	0.60
Glycolysis	regulates	pathway	0.60
ROS	regulates	gene	0.60
RNA	activates	gene	0.60
P53	activates	gene	0.60
P21	activates	gene	0.60
Mtor	inhibits	pathway	0.60
T Cell	inhibits	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (31)

Source	Relation	Type	Str
P62	regulates	gene	0.60
ERK	inhibits	gene	0.60
DNA	activates	gene	0.60
LAMP2	activates	gene	0.60
TKT	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
CTPS1	regulates	gene	0.60
HIF1	regulates	gene	0.60
BNIP3	regulates	gene	0.60
FOXO3	regulates	gene	0.60
LC3	regulates	gene	0.60
NRF2	regulates	gene	0.60
GAIN	activates	gene	0.60
IDH2	regulates	gene	0.60
TKT	regulates	gene	0.60
IDH2	expressed_in	entity	0.60
MTOR	inhibits	gene	0.60
ATM	inhibits	gene	0.60
MITOPHAGY	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
HIF	activates	gene	0.60
CANCER	activates	gene	0.60
ROS	regulates	gene	0.60
NIX	regulates	gene	0.60
AND	regulates	gene	0.60
NRF2	co_expressed_with	gene	0.50
P62	co_expressed_with	protein	0.50
Autophagy	regulates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIGAR in their description or question text

No additional research found