gene

NRCAM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRCAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

NRCAM is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in, activates. Associated with Als, Cancer, Carcinoma. Connected to 95 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NRCAM
Protein Type	Gene
Function	is a member of the L1 family of cell adhesion molecules (L1-CAMs).
Primary Expression	the developing brain and continues to be expressed in adult neurons
Pathways	Epithelial-Mesenchymal Transition
Ensembl ID	ENSG00000163631
GeneCards	NRCAM
Human Protein Atlas	NRCAM
Neuronal Migration	During cortical development, NRCAM guides neuronal precursors to their proper positions
Axon Guidance	Functions as a guidance molecule for developing axons, particularly in the optic chiasm and corticospinal tract
Synapse Formation	Localizes to synaptic membranes and participates in synapse assembly and function
Node of Ranvier Formation	Clusters at nodes of Ranvier in myelinated axons alongside other L1-CAMs (L1, Nr-CAM)
Autism Spectrum Disorder (ASD)	Multiple studies have identified NRCAM variants in individuals with autism
Multiple Sclerosis (MS)	Gene associations reported in GWAS studies
Epilepsy	Rare variants may contribute to seizure susceptibility
Associated Diseases	Cancer, Carcinoma, Hepatocellular Carcinoma, Liver Cancer
Interactions	MACF1
KG Connections	101 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NRCAM Gene

gene · 501 words

→

NRCAM Protein

protein · 872 words

→

Pathway Diagram

flowchart TD
    NRCAM["NRCAM"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Cancer["Cancer"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Als["Als"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Inflammation["Inflammation"]
    NRCAM["NRCAM"] -->|"therapeutic target"| Ms["Ms"]
    NRCAM["NRCAM"] -->|"therapeutic target"| NOTCH2["NOTCH2"]
    NRCAM["NRCAM"] -->|"therapeutic target"| EP300["EP300"]
    NRCAM["NRCAM"] -->|"therapeutic target"| CTNNB1["CTNNB1"]
    NRCAM["NRCAM"] -->|"therapeutic target"| NEUROD1["NEUROD1"]
    NRCAM["NRCAM"] -->|"therapeutic target"| MYC["MYC"]
    style NRCAM fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style NOTCH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EP300 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CTNNB1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NEUROD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MYC fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Hepatocellular Carcinoma	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Liver Cancer	implicated_in	disease	0.65
Carcinoma	implicated_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
CANCER	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
Epithelial-Mesenchymal Transition	activates	pathway	0.60
VEGFA	targets	gene	0.60
TERT	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Metastasis	associated_with	pathway	0.60
Invasion	causes	pathway	0.60
Stem Cell	implicated_in	pathway	0.60
TNFRSF19	targets	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60

Incoming (38)

Source	Relation	Type	Str
BAMBI	targets	gene	0.60
MACF1	activates	gene	0.60
MYC	causes	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
ATF3	targets	gene	0.60
DKK1	targets	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
FGF20	targets	gene	0.60
ALDH1A1	targets	gene	0.60
MITF	targets	gene	0.60
NEUROD1	targets	gene	0.60
BRG1	therapeutic_target	gene	0.60
CANCER	implicated_in	gene	0.60
GENES	therapeutic_target	gene	0.60
LEF1	targets	gene	0.60
ABCB1	targets	gene	0.60
CLDN1	targets	gene	0.60
JAG1	targets	gene	0.60
CD44	targets	gene	0.60
FGF18	targets	gene	0.60
MYC	targets	gene	0.60
IL10	targets	gene	0.60
NOTCH2	targets	gene	0.60
FZD7	targets	gene	0.60
AXIN2	targets	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NRCAM in their description or question text

No additional research found