gene

SMARCA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMARCA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

320Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SMARCA4 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, inhibits. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMARCA4
Chromosome	19p13.2
Function	ATP-dependent chromatin remodeling ATPase
Primary Expression	the cerebral cortex, hippocampus, and cerebellum
Amino Acids	1647 aa
Exons	35
Pathways	Epigenetic
Ensembl ID	ENSG00000127616
GeneCards	SMARCA4
Human Protein Atlas	SMARCA4
Associated Diseases	AD, ALI, Als, AMI, cancer
Known Drugs/Compounds	rapamycin
Interactions	AND, APOB, ARID1A, ASC, ATG, BECLIN1
SciDEX Hypotheses	Chromatin Remodeling-Mediated Nutrient Sensing Res
KG Connections	320 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SMARCA4

gene · 1049 words

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Pathway Diagram

graph TD
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Cancer["Cancer"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Ms["Ms"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Als["Als"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    SMARCA4["SMARCA4"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    IDH1["IDH1"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    VEGFA["VEGFA"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    MDM4["MDM4"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    APOB["APOB"] -->|"therapeutic target"| SMARCA4["SMARCA4"]
    style SMARCA4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (184)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Wnt	therapeutic_target	pathway	0.70
DNA	associated_with	gene	0.70
Renal Cell Carcinoma	contributes_to	disease	0.65
Aging	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
LEF1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
APOB	inhibits	gene	0.60
TERT	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
CTNNB1	regulates	gene	0.60
SF3B1	associated_with	gene	0.60
Dna Methylation	therapeutic_target	pathway	0.60
Dna Methylation	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
CANCER	therapeutic_target	gene	0.60
stem cells	expressed_in	cell_type	0.60
ARID1A	interacts_with	gene	0.60
MYC	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60

Incoming (136)

Source	Relation	Type	Str
h-var-a09491064e	targets_gene	hypothesis	0.90
TERT	therapeutic_target	gene	0.70
VEGFA	therapeutic_target	gene	0.70
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
SF3B1	associated_with	gene	0.60
MET	therapeutic_target	gene	0.60
APOB	associated_with	gene	0.60
EEF1A1	associated_with	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
CREBBP	regulates	gene	0.60
GAIN	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
KRAS	activates	gene	0.60
IDH1	therapeutic_target	gene	0.60
IKK	activates	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
AXIN1	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	regulates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
MAP1LC3	associated_with	gene	0.60
WNT	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
CCDC50	activates	gene	0.60
P53	therapeutic_target	gene	0.60
PTEN	contributes_to	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Chromatin Remodeling-Mediated Nutrient Sensing Restoration	0.914	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMARCA4 in their description or question text

No additional research found