protein

VEGFA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

972Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for VEGFA Protein - Vascular Endothelial Growth Factor A

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🔬 Protein Info

Gene Symbol	VEGFA
Full Name	Vascular Endothelial Growth Factor A
Aliases	Page for VEGFA Protein
Function	VEGF exerts its effects by binding to receptor tyrosine kinases (VEGFR-1/Flt-1 and VEGFR-2/KDR/Flk-1) on endothelial cells and other cell types.
Molecular Weight	24 kDa
Pathways	Akt, Autophagy, Mapk, Oxidative Stress, Pi3K
Ensembl ID	ENSG00000112715
GeneCards	VEGFA
Human Protein Atlas	VEGFA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	quercetin
Interactions	ACTB, AGGF1, AKT, AKT1, ALS, ALZHEIMER
KG Connections	972 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VEGFA — Vascular Endothelial Growth Factor A

gene · 731 words

→

VEGFA Protein - Vascular Endothelial Growth Factor A

protein · 586 words

→

Pathway Diagram

graph TD
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Cancer["Cancer"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Carcinoma["Carcinoma"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Ms["Ms"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| Als["Als"]
    VEGFA["VEGFA"] -->|"Biomarker For"| Neurodegeneration["Neurodegeneration"]
    VEGFA["VEGFA"] -->|"Associated With"| Inflammation["Inflammation"]
    VEGFA["VEGFA"] -->|"Associated With"| Neuroinflammation["Neuroinflammation"]
    VEGFA["VEGFA"] -->|"Biomarker For"| Alzheimer["Alzheimer"]
    IDH1["IDH1"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    IL9["IL9"] -->|"Biomarker For"| VEGFA["VEGFA"]
    SF3B1["SF3B1"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    TERT["TERT"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    SMARCA4["SMARCA4"] -->|"Therapeutic Target"| VEGFA["VEGFA"]
    style VEGFA fill:#0d47a1,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Neuroinflammation fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style IDH1 fill:#8d4900,color:#e0e0e0
    style IL9 fill:#8d4900,color:#e0e0e0
    style SF3B1 fill:#8d4900,color:#e0e0e0
    style TERT fill:#8d4900,color:#e0e0e0
    style SMARCA4 fill:#8d4900,color:#e0e0e0

Outgoing (518)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Angiogenesis	regulates	process	0.95
Diabetic Retinopathy	therapeutic_target	disease	0.95
Tumor	therapeutic_target	disease	0.95
Als	therapeutic_target	disease	0.95
Vascular Permeability	regulates	process	0.95
Diabetic Retinopathy	involved_in	disease	0.95
angiogenesis	promotes	process	0.95
Angiogenesis	promotes	process	0.90
Pathological Angiogenesis	promotes	phenotype	0.90
Astrocytes	expressed_in	cell_type	0.90
Cerebrovascular Integrity	biomarker_for	process	0.85
Insomnia	therapeutic_target	disease	0.85
Retinal Barrier Breakdown	mediates	phenotype	0.80
endothelial cells	expressed_in	cell_type	0.80
ENDOTHELIAL NITRIC OXIDE SYNTHASE	activates	enzyme	0.80
Angiogenesis	activates	pathway	0.80
Colorectal Cancer	therapeutic_target	disease	0.75
Als	biomarker_for	disease	0.75
Depression	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
Als	activates	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Ischemia	activates	disease	0.75
Stroke	activates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Breast Cancer	therapeutic_target	disease	0.75
pericytes	expressed_in	cell_type	0.70
Tnf Signaling	therapeutic_target	pathway	0.70
TERT	therapeutic_target	gene	0.70
vascular permeability	increases	process	0.70
MAPK signaling	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
SMARCA4	therapeutic_target	gene	0.70
JAK	therapeutic_target	gene	0.70
endothelial cells	associated_with	cell_type	0.70
Mapk	activates	pathway	0.70
DEPRESSION	therapeutic_target	gene	0.70
Wnt	therapeutic_target	pathway	0.70
Inflammation	biomarker_for	disease	0.65
Sickle Cell	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ASTROCYTES	treats	cell_type	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
CALCIUM SIGNALING	regulates	pathway	0.65
Als	interacts_with	disease	0.65
Diabetes	interacts_with	disease	0.65
Inflammation	activates	disease	0.65
Aging	encodes	disease	0.65

Incoming (454)

Source	Relation	Type	Str
TNF	targets	gene	1.00
GENES	therapeutic_target	gene	1.00
HIF1A	upregulates	gene	0.90
AKT1	targets	gene	0.90
CANCER	therapeutic_target	gene	0.90
cardamom nanoemulsion	downregulates	compound	0.85
HIF-1Α	upregulates	protein	0.85
AGGF1	activates	gene	0.80
UCHL1	upregulates	protein	0.80
IL6	targets	gene	0.80
INFLAMMATION	associated_with	gene	0.80
AKT	therapeutic_target	gene	0.80
PI3K	therapeutic_target	gene	0.80
STAT3	therapeutic_target	gene	0.80
IL-6	activates	gene	0.70
TNF	associated_with	gene	0.70
TNF-Α	therapeutic_target	gene	0.70
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.70
EGFR	targets	gene	0.70
JUN	targets	gene	0.70
BAX	activates	gene	0.70
BDNF	associated_with	gene	0.70
CYTOKINES	biomarker_for	gene	0.70
IL-6	associated_with	gene	0.70
TP53	targets	gene	0.70
VEGF	activates	gene	0.70
WNT SIGNALING	associated_with	pathway	0.65
TH	activates	gene	0.65
TH	regulates	gene	0.65
FERROPTOSIS	targets	phenotype	0.65
AMYLOID	interacts_with	protein	0.65
LACTATE	causes	phenotype	0.65
ASTROCYTE	interacts_with	cell_type	0.65
LEF1	targets	gene	0.60
ASTROCYTES	activates	gene	0.60
CCL2	expressed_in	gene	0.60
NEUROD1	targets	gene	0.60
NRCAM	targets	gene	0.60
RNA	encodes	gene	0.60
CHIT1	associated_with	gene	0.60
FGF20	targets	gene	0.60
PTGS2	targets	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
NOTCH2	targets	gene	0.60
SMOC2	contributes_to	gene	0.60
MYC	targets	gene	0.60
ALDH1A1	targets	gene	0.60
MITF	targets	gene	0.60
RAGE	interacts_with	gene	0.60
ABCB1	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do clinical manifestations overlap despite distinct underlying etiologies in

neuroinflammation | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract notes that clinical presentations overlap across different myelopat

closed · Rounds: 4 · Score: 0.86 · 2026-04-09

Related Research

Hypotheses and analyses mentioning VEGFA in their description or question text

No additional research found