gene

SPI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

454Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SPI1/PU.1 - master microglial transcription factor, AD risk gene

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🧬 Gene Info

Gene Symbol	SPI1
Full Name	PU.1 Transcription Factor / Spi-1 Proto-Oncogene
Aliases	SPI1/PU.1
Chromosome	19q13.3
Protein Type	Transcription Factor
Function	encodes a transcription factor of the E26 transformation-specific (ETS) family.
Amino Acids	270 aa
Pathways	Amyloid, Mtor, Pi3K/Akt
UniProt ID	P17947
NCBI Gene ID	6678
Ensembl ID	ENSG00000135336
OMIM	165010
GeneCards	SPI1
Human Protein Atlas	SPI1
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	454 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPI1 — AlphaFold P17947 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPI1 Gene - PU.1

gene · 2569 words

→

PU.1 Protein (SPI1)

protein · 878 words

→

Pathway Diagram

graph TD
    SPI1["SPI1"]
    SPI1 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    SPI1 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    SPI1 -->|"target for"| Alzheimer["Alzheimer"]
    SPI1 -->|"regulates"| Ms["Ms"]
    SPI1 -->|"target for"| Parkinson["Parkinson"]
    SPI1 -.biomarker for.-> Als["Als"]
    SPI1 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    SPI1 -->|"activates"| Stroke["Stroke"]
    C1Q["C1Q"] -->|"expressed in"| SPI1
    C1QA["C1QA"] -->|"expressed in"| SPI1
    C1QC["C1QC"] -->|"expressed in"| SPI1
    CEBPA["CEBPA"] -->|"regulates"| SPI1
    HSPA1A["HSPA1A"] -->|"target for"| SPI1
    TFE3["TFE3"] -->|"regulates"| SPI1
    TP53["TP53"] -->|"regulates"| SPI1
    TRAF6["TRAF6"] -.biomarker for.-> SPI1
    P38["P38"] -.biomarker for.-> SPI1
    CD4["CD4"] -.biomarker for.-> SPI1

Outgoing (234)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SPI1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Microglial/Macrophage Inflammatory Response	regulates	process	0.95
PI3K/AKT/MTOR Signaling Pathway	activates	pathway	0.90
PU.1	encodes	protein	0.90
Microglia	expressed_in	cell_type	0.90
Neuroinflammation	regulates	process	0.85
APOE	regulates	gene	0.85
Autophagy	upregulates	process	0.85
Phagocytosis	upregulates	process	0.85
Debris Clearance	associated_with	process	0.85
C1QC	regulates	entity	0.85
C1QA	regulates	entity	0.85
Angiogenesis	associated_with	process	0.80
Glycolysis	upregulates	process	0.80
HSPB1	regulates	gene	0.80
Remyelination	associated_with	process	0.80
Complement Activation	associated_with	process	0.80
Als	activates	disease	0.75
microglia	expressed_in	cell_type	0.70
Alzheimer's disease	biomarker_for	disease	0.70
C1Q	regulates	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
chromatin_accessibility	modulates	mechanism	0.70
neuroinflammation	amplifies	phenotype	0.70
neurovascular_unit	orchestrates	cell_type	0.70
synaptic_plasticity	inhibits	phenotype	0.70
neuroinflammatory_memory	causes	phenotype	0.70
microglia	regulates	cell_type	0.70
microglial_activation	maintains	phenotype	0.70
glycolytic_metabolism	regulates	pathway	0.70
neuroinflammation	contributes_to	phenotype	0.70
atherosclerosis	associated_with	disease	0.70
macrophages	expressed_in	cell_type	0.70
Cancer	activates	disease	0.65
Als	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Stroke	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Atherosclerosis	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65

Incoming (220)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SPI1	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	disease	0.82
ALZHEIMER DISEASE	associated_with	gene	0.80
APOE	activates	gene	0.70
STAT3	activates	gene	0.70
chronic_vascular_inflammation	regulates	phenotype	0.70
C1Q	enhances	gene	0.70
APOE	associated_with	gene	0.66
AMYLOID	associated_with	protein	0.66
LRP1	activates	gene	0.60
PLCG2	implicated_in	gene	0.60
PSEN1	implicated_in	gene	0.60
PTK2B	implicated_in	gene	0.60
SORL1	implicated_in	gene	0.60
MYH9	encodes	gene	0.60
CCND1	encodes	gene	0.60
ACE	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
ADAM10	associated_with	gene	0.60
APH1B	associated_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
PHAGOCYTOSIS	associated_with	entity	0.60
AND	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
MIRNAS	encodes	gene	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
MMP12	activates	gene	0.60
CD33	activates	gene	0.60
TYROBP	activates	gene	0.60
CANCER	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
METTL3	regulates	gene	0.60
TREM2	activates	gene	0.60
AKT	activates	gene	0.60
IL10	regulates	gene	0.60
CD33	regulates	gene	0.60
MS4A6A	regulates	gene	0.60
PILRA	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
TFE3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors identify SPI1 as a potential transcription factor regulating the hub

closed · Rounds: 4 · Score: 0.93 · 2026-04-09