gene

FZD7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FZD7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	FZD7
Full Name	Frizzled Class Receptor 7
Chromosome	2q33.3
Protein Type	Receptor
Function	FZD7 (Frizzled Class Receptor 7) is a seven-transmembrane receptor belonging to the Frizzled family of Wnt receptors.
Primary Expression	neural stem cells and progenitor populations
UniProt ID	O75084
NCBI Gene ID	8324
Ensembl ID	ENSG00000155729
OMIM	603410
GeneCards	FZD7
Human Protein Atlas	FZD7
High affinity ligands	Binds Wnt1, Wnt2, Wnt3, and Wnt3A with high specificity
Stem cell pluripotency	Maintains embryonic stem cell self-renewal through β-catenin stabilization
Progenitor proliferation	Promotes expansion of neural progenitor cells during development
Associated Diseases	Alzheimer's Disease, Cancer, Autism Spectrum Disorder
Interactions	WNT
KG Connections	91 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FZD7 — AlphaFold O75084 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

fzd7

gene · 1027 words

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FZD7 Protein

protein · 590 words

→

Pathway Diagram

graph TD
    FZD7["FZD7 (Frizzled-7 Receptor)"]
    WNT["Wnt Signaling Pathway"]
    BETACAT["beta-Catenin"]
    AXIN2["AXIN2"]
    CD44["CD44"]
    JAG1["JAG1 (Jagged1)"]
    NOTCH["Notch Signaling"]
    ALS["Amyotrophic Lateral Sclerosis"]
    MS["Multiple Sclerosis"]
    INFLAMMATION["Neuroinflammation"]
    NEUROREGENERATION["Neuroregeneration"]
    STEMCELLS["Neural Stem Cells"]
    SYNAPTIC["Synaptic Plasticity"]
    NEUROPROTECTION["Neuroprotective Mechanisms"]
    ATF3["ATF3"]
    CELLSURVIVAL["Cell Survival"]

    FZD7 -->|"activates"| WNT
    WNT -->|"stabilizes"| BETACAT
    BETACAT -->|"regulates"| AXIN2
    BETACAT -->|"promotes"| NEUROREGENERATION
    FZD7 -->|"interacts with"| JAG1
    JAG1 -->|"activates"| NOTCH
    NOTCH -->|"promotes"| STEMCELLS
    FZD7 -->|"therapeutic target"| ALS
    FZD7 -->|"therapeutic target"| MS
    FZD7 -->|"modulates"| INFLAMMATION
    WNT -->|"enhances"| SYNAPTIC
    FZD7 -->|"regulates"| CD44
    CD44 -->|"promotes"| NEUROPROTECTION
    ATF3 -->|"influences"| CELLSURVIVAL
    FZD7 -->|"targets"| ATF3
    NEUROREGENERATION -->|"counteracts"| ALS

    style FZD7 fill:#1a3a4a,stroke:#4fc3f7
    style NEUROREGENERATION fill:#1b5e20
    style NEUROPROTECTION fill:#1b5e20
    style CELLSURVIVAL fill:#1b5e20
    style SYNAPTIC fill:#1b5e20
    style ALS fill:#7d4200
    style MS fill:#7d4200
    style INFLAMMATION fill:#ef5350
    style AXIN2 fill:#4a1a6b
    style JAG1 fill:#4a1a6b
    style ATF3 fill:#4a1a6b
    style CD44 fill:#4a1a6b

Outgoing (53)

Target	Relation	Type	Str
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
AXIN1	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
MYC	targets	gene	0.60
NEUROD1	targets	gene	0.60
NOTCH2	targets	gene	0.60
SNAI1	targets	gene	0.60
TERT	targets	gene	0.60
JAG1	targets	gene	0.60
BAMBI	therapeutic_target	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Notch	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
TNFRSF19	targets	gene	0.60
WNT	inhibits	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
VEGFA	targets	gene	0.60
MITF	targets	gene	0.60
IL10	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
LEF1	targets	gene	0.60
NRCAM	targets	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60

Incoming (38)

Source	Relation	Type	Str
APC	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALDH1A1	targets	gene	0.60
CLDN1	targets	gene	0.60
CD44	targets	gene	0.60
FGF18	targets	gene	0.60
AXIN2	targets	gene	0.60
DKK1	targets	gene	0.60
ATF3	targets	gene	0.60
BAMBI	targets	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
FGF20	targets	gene	0.60
ABCB1	targets	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FZD7 in their description or question text

No additional research found