gene

PPARD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPARD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	PPARD
Aliases	PPARδ, PPAR-beta, NR1C2
Chromosome	6p21.31
Protein Type	Gene
Function	Target genes are involved in: - Fatty acid oxidation - Glucose metabolism - Lipid metabolism - Inflammation - Cell proliferation and differentiation
Pathways	Akt, Mapk, Sphingolipid
NCBI Gene ID	5468
GeneCards	PPARD
Human Protein Atlas	PPARD
Associated Diseases	neurodegeneration
Known Drugs/Compounds	Bezafibrate, Kd3010, KD3010, T3D-959
Interactions	PPARGC1A
KG Connections	128 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ppard

gene · 897 words

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Pathway Diagram

graph TD
    PPARD["PPARD"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    PPARD["PPARD"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    PPARD["PPARD"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    PPARD["PPARD"] -->|"therapeutic target"| Cancer["Cancer"]
    PPARD["PPARD"] -->|"therapeutic target"| Als["Als"]
    PPARD["PPARD"] -->|"therapeutic target"| Inflammation["Inflammation"]
    PPARGC1A["PPARGC1A"] -->|"activates"| PPARD["PPARD"]
    FGF20["FGF20"] -->|"therapeutic target"| PPARD["PPARD"]
    BRG1["BRG1"] -->|"therapeutic target"| PPARD["PPARD"]
    NRCAM["NRCAM"] -->|"therapeutic target"| PPARD["PPARD"]
    style PPARD fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (70)

Target	Relation	Type	Str
Metabolic Pathways	regulates	pathway	0.90
Inflammatory Pathways	regulates	pathway	0.90
inflammatory pathway	regulates	pathway	0.90
Mitochondrial Function	regulates	pathway	0.90
mitochondrial function	regulates	process	0.90
metabolic pathway	regulates	pathway	0.90
oxidative phosphorylation	upregulates	pathway	0.85
Motor Performance	modulates	phenotype	0.80
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.80
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
RXRB	regulates	gene	0.60
SNAI1	targets	gene	0.60
TERT	targets	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Notch	therapeutic_target	pathway	0.60
HO-1	therapeutic_target	gene	0.60
Autophagy	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
BAMBI	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
INFLAMMATION	regulates	gene	0.60
Sphingolipid	regulates	pathway	0.60
Akt	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
TNFRSF19	targets	gene	0.60
PTGS2	targets	gene	0.60
VEGFA	targets	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60

Incoming (58)

Source	Relation	Type	Str
Bezafibrate	activates	drug	0.95
T3D-959	activates	drug	0.90
PPARGC1A	activates	gene	0.90
KD3010	activates	drug	0.85
Kd3010	activates	drug	0.80
MYC	targets	gene	0.70
HIF	targets	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
FGF20	targets	gene	0.60
NRCAM	targets	gene	0.60
NOTCH2	targets	gene	0.60
NEUROD1	targets	gene	0.60
ABCB1	targets	gene	0.60
LEF1	targets	gene	0.60
FZD7	targets	gene	0.60
JAG1	targets	gene	0.60
MITF	targets	gene	0.60
AXIN2	targets	gene	0.60
CD44	targets	gene	0.60
ALDH1A1	targets	gene	0.60
FGF18	targets	gene	0.60
ATF3	targets	gene	0.60
IL10	targets	gene	0.60
DKK1	targets	gene	0.60
MAPK3	targets	gene	0.60
HIF1A	targets	gene	0.60
CLDN1	targets	gene	0.60
BAMBI	targets	gene	0.60
BRG1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
BECLIN1	therapeutic_target	gene	0.60
P62	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
RXRA	regulates	gene	0.60
PPARA	regulates	gene	0.60
MAPK3	regulates	gene	0.60
AKT1	regulates	gene	0.60
MAPK1	regulates	gene	0.60
ADRB2	targets	gene	0.60
HMOX1	targets	gene	0.60
GENES	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPARD in their description or question text

No additional research found