gene

GAIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1884Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

2Experiments

0Debates

Summary

Page for GAIN Gene - GABA-A Receptor Associated Protein Like 2

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🧬 Gene Info

Gene Symbol	GAIN
Full Name	GAIN - GABA-A Receptor Associated Protein Like 2
Aliases	Page for GAIN Gene, GABARAPL2
Chromosome	16p13.3
Protein Type	Gene
Function	encodes a protein belonging to the GABA-A receptor-associated protein (GABARAP) family.
Primary Expression	various tissues with high expression in: - Brain (particularly in neurons) - Heart - Skeletal muscle
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Cholesterol Metabolism
NCBI Gene ID	124454
GeneCards	GAIN
Human Protein Atlas	GAIN
Associated Diseases	aging, Als, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Interactions	ACAT1, ACC, ACHE, Actin, AGING, AIF
KG Connections	1884 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GAIN Gene - GABA-A Receptor Associated Protein Like 2

gene · 585 words

→

GAIN Protein (GABARAPL2) - GABA-A Receptor Associated Protein Like 2

protein · 673 words

→

Pathway Diagram

graph TD
    GAIN["GAIN"] -->|"activates"| Cancer["Cancer"]
    GAIN["GAIN"] -->|"activates"| Carcinoma["Carcinoma"]
    GAIN["GAIN"] -->|"activates"| Ms["Ms"]
    GAIN["GAIN"] -->|"activates"| Als["Als"]
    GAIN["GAIN"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    GAIN["GAIN"] -->|"biomarker for"| Inflammation["Inflammation"]
    TIGAR["TIGAR"] -->|"activates"| GAIN["GAIN"]
    IDH2["IDH2"] -->|"activates"| GAIN["GAIN"]
    TMEM119["TMEM119"] -->|"biomarker for"| GAIN["GAIN"]
    P2RY12["P2RY12"] -->|"biomarker for"| GAIN["GAIN"]
    style GAIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1288)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Tumor	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Neurodegeneration	activates	disease	1.00
CANCER	associated_with	gene	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Tumor	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Als	causes	disease	1.00
Als	associated_with	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	associated_with	disease	1.00
PI3K	therapeutic_target	gene	1.00
GENES	activates	gene	1.00
Apoptosis	activates	pathway	1.00
Apoptosis	implicated_in	pathway	1.00
INFLAMMATION	activates	gene	1.00
Inflammation	regulates	disease	0.95
Aging	therapeutic_target	disease	0.95
Tumor	therapeutic_target	disease	0.95
Cancer	causes	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Als	expressed_in	disease	0.95
GENES	therapeutic_target	gene	0.90
DNA	activates	gene	0.90
DNA	therapeutic_target	gene	0.90
AKT	therapeutic_target	gene	0.90
Autophagy	activates	pathway	0.90
CANCER	activates	gene	0.90
Autoimmune	therapeutic_target	disease	0.85
Diabetes	therapeutic_target	disease	0.85
Cancer	inhibits	disease	0.85
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.85
Breast Cancer	therapeutic_target	disease	0.85
Obesity	activates	disease	0.85
Oxidative Stress	activates	pathway	0.80
Autophagy	implicated_in	pathway	0.80
TP53	implicated_in	gene	0.80
Immune Response	activates	pathway	0.80
ALS	causes	gene	0.80
GENES	associated_with	gene	0.80
Glycolysis	activates	pathway	0.80
Cell Cycle	implicated_in	pathway	0.80
P53	associated_with	gene	0.80
ASTROCYTES	activates	gene	0.80
DNA	associated_with	gene	0.80
AMYLOID	activates	gene	0.80
Nf-Κb	activates	pathway	0.80

Incoming (596)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	implicated_in	gene	1.00
GENES	therapeutic_target	gene	0.90
PTEN	therapeutic_target	gene	0.90
NEURODEGENERATION	activates	gene	0.80
DNA	therapeutic_target	gene	0.70
SOD1	therapeutic_target	gene	0.70
PIEZO1	associated_with	gene	0.70
TNF	regulates	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
TREM2	activates	gene	0.70
HUNTINGTON	associated_with	gene	0.70
C9ORF72	activates	gene	0.70
DNA	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
PINK1	therapeutic_target	gene	0.70
CANCER	biomarker_for	gene	0.70
P53	regulates	gene	0.60
C9ORF72 REPEAT EXPANSION	causes	gene	0.60
NEURON	protects_against	gene	0.60
MOTOR NEURONS	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
CANCER	regulates	gene	0.60
HIPPO	phosphorylates	gene	0.60
ERBB2	activates	gene	0.60
RAS	activates	gene	0.60
ALZHEIMER	degrades	gene	0.60
NEURODEGENERATIVE DISORDERS	degrades	gene	0.60
NEURODEGENERATION	causes	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
NEUROTOXICITY	causes	gene	0.60
HUNTINGTON	causes	gene	0.60
TNFRSF11A	activates	gene	0.60
APOPTOSIS	treats	gene	0.60
MICROGLIA	regulates	gene	0.60
PARKINSON	causes	gene	0.60
LYSOSOME	causes	gene	0.60
ASTROCYTE	causes	gene	0.60
MOTOR NEURONS	therapeutic_target	gene	0.60
MOTOR NEURONS	associated_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
SYNAPSE	interacts_with	gene	0.60
AMYLOID-BETA	interacts_with	gene	0.60
AMPK	inhibits	gene	0.60
TNF-Α	regulates	gene	0.60
IL-10	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
G2019S primarily raises baseline LRRK2 kinase activity rathe	0.790	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil	0.778	neurodegeneration	How do gut microbiome-derived metabolite
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against T	0.604	neurodegeneration	Should microtubule-stabilizing drugs be

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PGC-1α knockout analysis of PV+ interneuron maturation	validation	neurodevelopmental disorders	0.850	0.00	knockout mice	proposed	N/A
PV+ interneuron subtype diversification analysis	exploratory	neurodevelopmental disorders	0.750	0.00	mouse cortical PV+ interneuron	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAIN in their description or question text

No additional research found