gene

TERT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TERT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

529Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Telomerase Reverse Transcriptase - catalytic subunit of telomerase with roles in cellular senescence, mitochondrial function, and neurodegeneration

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🧬 Gene Info

Gene Symbol	TERT
Full Name	Telomerase Reverse Transcriptase
Chromosome	5p15.33
Function	dyskerin (DKC1): Stabilizes the complex
Primary Expression	hippocampal subgranular zone (SGZ)
Molecular Weight	127 kDa
Amino Acids	1132 aa
Exons	16
Pathways	Telomere Dysfunction
UniProt ID	[O14748](https://www.uniprot.org/uniprot/O14748)
Ensembl ID	ENSG00000164362
OMIM	607409
GeneCards	TERT
Human Protein Atlas	TERT
Reverse transcriptase activity	Catalyzes addition of TTAGGG repeats to telomeres
Associated Diseases	AD, ALI, Als, AMI, cancer
Known Drugs/Compounds	TAC
Interactions	ACVR2A, AGING, AKT, AKT3, AMPK, AND
KG Connections	529 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TERT["TERT"] -->|"Promotes"| telomere_synthesis["telomere synthesis"]
    TERT["TERT"] -->|"Prevents"| cellular_senescence["cellular senescence"]
    TERT["TERT"] -->|"Modulates"| aging["aging"]
    TERT["TERT"] -->|"Therapeutic Target"| Cancer["Cancer"]
    TERT["TERT"] -->|"Therapeutic Target"| Carcinoma["Carcinoma"]
    TERT["TERT"] -->|"Therapeutic Target"| Ms["Ms"]
    TERT["TERT"] -->|"Therapeutic Target"| Als["Als"]
    TERT["TERT"] -->|"Biomarker For"| Neurodegeneration["Neurodegeneration"]
    TAC["TAC"] -->|"Activates"| TERT["TERT"]
    MEK_ERK_AP_1["MEK/ERK/AP-1"] -->|"Regulates"| TERT["TERT"]
    IDH1["IDH1"] -->|"Therapeutic Target"| TERT["TERT"]
    VEGFA["VEGFA"] -->|"Therapeutic Target"| TERT["TERT"]
    MDM4["MDM4"] -->|"Therapeutic Target"| TERT["TERT"]
    style TERT fill:#8d4900,color:#e0e0e0
    style telomere_synthesis fill:#1b5e20,color:#e0e0e0
    style cellular_senescence fill:#1b5e20,color:#e0e0e0
    style aging fill:#1b5e20,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Neurodegeneration fill:#b71c1c,color:#e0e0e0
    style TAC fill:#00838f,color:#e0e0e0
    style MEK_ERK_AP_1 fill:#9C27B0,color:#e0e0e0
    style IDH1 fill:#8d4900,color:#e0e0e0
    style VEGFA fill:#8d4900,color:#e0e0e0
    style MDM4 fill:#8d4900,color:#e0e0e0

Outgoing (340)

Target	Relation	Type	Str
Telomere Dysfunction	causes	mechanism	0.95
Hepatocellular Carcinoma	biomarker_for	disease	0.90
Telomere Dysfunction	regulates	mechanism	0.85
BRAIN TUMOURS	associated_with	entity	0.85
Telomere Maintenance	involved_in	process	0.85
Tumor	activates	disease	0.85
NASH-Related Hepatocellular Carcinoma	biomarker_for	disease	0.80
MAPK1	activates	gene	0.80
Telomere Dysfunction	involved_in	process	0.80
Oxidative Stress	activates	pathway	0.80
GENES	associated_with	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
Fibrosis	activates	disease	0.75
Als	activates	disease	0.75
Aging	activates	disease	0.75
Senescence	activates	disease	0.75
Als	associated_with	disease	0.75
Glioblastoma	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Cancer	associated_with	disease	0.75
CANCER	activates	gene	0.70
Wnt	therapeutic_target	pathway	0.70
SMARCA4	therapeutic_target	gene	0.70
SENESCENCE	protects_against	phenotype	0.70
Tgf-Β	activates	pathway	0.70
telomere synthesis	activates	process	0.70
NRF2	inhibits	gene	0.70
CDKN2A	associated_with	gene	0.70
cellular senescence	protects_against	process	0.70
Apoptosis	activates	pathway	0.70
GENES	therapeutic_target	gene	0.70
TP53	activates	gene	0.70
EGFR	activates	gene	0.70
Epigenetic	contributes_to	pathway	0.70
Nf-Κb	activates	pathway	0.70
aging	regulates	process	0.70
Ataxia	expressed_in	disease	0.65
Aging	contributes_to	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Glioma	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Senescence	expressed_in	disease	0.65
Als	expressed_in	disease	0.65

Incoming (189)

Source	Relation	Type	Str
GABPB1	activates	gene	0.90
VEGFA	therapeutic_target	gene	0.70
MEK/ERK/AP-1	regulates	pathway	0.70
TAC	activates	drug	0.70
LZTR1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
BRG1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
GJA1	regulates	gene	0.60
ACVR2A	activates	gene	0.60
CTNNB1	activates	gene	0.60
CD38	therapeutic_target	gene	0.60
SRC	activates	gene	0.60
STAT3	activates	gene	0.60
ERK1	activates	gene	0.60
CREBBP	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
CANCER	biomarker_for	gene	0.60
WNT	inhibits	gene	0.60
GENES	associated_with	gene	0.60
PD-L1	inhibits	gene	0.60
PINK1	activates	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
DKK1	targets	gene	0.60
FZD7	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
SNAI1	targets	gene	0.60
AKT3	activates	gene	0.60
CDKN2A	activates	gene	0.60
MDM4	activates	gene	0.60
PDGFRA	activates	gene	0.60
PTEN	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ANTIOXIDANT GENES	therapeutic_target	gene	0.60
AGING	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
MICRORNAS	interacts_with	gene	0.60
NF-ΚB	activates	gene	0.60
NF-ΚB	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TERT in their description or question text

No additional research found